Results 131 to 140 of about 335,323 (145)

Inhibition of Experimental Proliferative Vitreoretinopathy with Protein Kinase C Inhibitor (Chelerythrine Chloride) and Melatonin

Ophthalmologica, 2005
<i>Purpose:</i> To investigate whether a protein kinase C (PKC) inhibitor and melatonin prevent proliferative vitreoretinopathy (PVR). <i>Methods:</i> Twentypigmented rabbits were used in this study. All rabbits except controls received an intravitreal injection of 0.15 ml (75,000 units) of platelet-rich plasma into their left ...
Hamdi, Er, Yusuf, Turkoz, Bülent, Mizrak, Hakan, Parlakpinar   +3 more
openaire   +2 more sources

Investigation of the inhibitory effects of chelerythrine chloride on the translocation of the protein kinase C βI, βII, ζ in human neutrophils

Il Farmaco, 2001
The protein kinase C (PKC) is a serine/threonine kinase, consisting of different isoforms, implicated in numerous processes of signal transduction. To understand this enzyme well, different pharmacological tools were developed. To activate PKC specifically, phorbol esters were previously used but recent research has shown that these compounds are able ...
X, Siomboing, B, Gressier, T, Dine, C, Brunet, M, Luyckx, M, Cazin, J C, Cazin   +6 more
openaire   +2 more sources

Chelerythrine inhibits the sarco/endoplasmic reticulum Ca2+-ATPase and results in cell Ca2+ imbalance

Archives of Biochemistry and Biophysics, 2015
The isoquinoline alkaloid chelerythrine is described as an inhibitor of SERCA. The ATPase inhibition presented two non-competitive components, Ki1 = 1, 2 μM and Ki2 = 26 μM.
Raphaël C Valente, Julio Mignaco, Carlos Frederico Leite Fontes   +2 more
exaly   +2 more sources

In vitro and in vivo activity of protein kinase C inhibitor chelerythrine chloride induces tumor cell toxicity and growth delay in vivo.

Clinical cancer research : an official journal of the American Association for Cancer Research, 2000
Although clonogenic or divisional death is the main mechanism by which DNA-damaging agents demonstrate antitumor activity, recent data indicate that strategies specifically designed to trigger apoptosis may also prove to be useful antitumor agents. Protein kinase C (PKC) isoenzymes are involved in the regulation of cell proliferation, differentiation ...
S J, Chmura, M E, Dolan, A, Cha, H J, Mauceri, D W, Kufe, R R, Weichselbaum   +5 more
openaire   +1 more source

CHELERYTHRINE CHLORIDE INDUCES RAPID PMN APOPTOSIS THROUGH ACTIVATION OF CASPASE-3

Shock, 1999
J. F. Sweeney, P. K. Nguyen, K. B. Atkins, D. B. Hinshaw   +3 more
openaire   +1 more source

88 Decreasing the apoptotic threshold with chelerythrine chloride enhances radiation cures in vivo

International Journal of Radiation Oncology*Biology*Physics, 1997
Steven J. Chmura, Helena Mauceri, Jose Quintans, Donald W. Kufe, Ralph R. Weichselbaum   +4 more
openaire   +1 more source

Induction of EGR-TNF Radioinducible virus through BH3 Domain Antagonism with Chelerythrine Chloride

International Journal of Radiation Oncology*Biology*Physics, 2009
L.C. Herman, A.A. Chaudhary, S.J. Chmura, M.L. Pytynia, M.B. Altman, H.J. Maurceri, M.A. Beckett, T.E. Darga, R.R. Weichselbaum   +8 more
openaire   +1 more source

Chelerythrine chloride inhibits the progression of colorectal cancer by targeting cancer‐associated fibroblasts through intervention with WNT10B/β‐catenin and TGFβ2/Smad2/3 axis

Phytotherapy Research, 2023
Nianzhi Chen, Jianyuan Tang, Dan Liang   +2 more
exaly  

In vitro antifungal activity and possible mechanisms of action of chelerythrine

Pesticide Biochemistry and Physiology, 2020
Na Zhao, Min Zhao, Xuefeng Liu
exaly  

Stimulation by chelerythrine of the phosphorylation of the amino acid serine in an ~20 kDa protein present in the mitochondrial fraction of the rat retina

Biochemical Pharmacology, 1996
John B Lombardini
exaly