Results 111 to 120 of about 226,393 (319)

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Rapid Chemical Enrichment by Intermittent Star Formation in GN-z11

The Astrophysical Journal Letters
We interpret the peculiar supersolar nitrogen abundance recently reported by the James Webb Space Telescope observations for GN-z11 ( z = 10.6) using our state-of-the-art chemical evolution models.
Chiaki Kobayashi, Andrea Ferrara
doaj   +1 more source

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

On the Chemical Abundances of Miras in Clusters: V1 in the Metal-rich Globular NGC 5927* [PDF]

, 2018
V. D’Orazi, D. Magurno, G. Bono, N. Matsunaga, V. F. Braga, S. S. Elgueta, K. Fukue, S. Hamano, L. Inno, N. Kobayashi, S. Kondo, M. Monelli, M. Nonino, N. Przybilla, H. Sameshima, I. Saviane, D. Taniguchi, F. Thevenin, M. Urbaneja-Perez, A. Watase, A. Arai, M. Bergemann, R. Buonanno, M. Dall’Ora, R. Da Silva, M. Fabrizio, I. Ferraro, G. Fiorentino, P. Francois, R. Gilmozzi, G. Iannicola, Y. Ikeda, M. Jian, H. Kawakita, R. P. Kudritzki, B. Lemasle, M. Marengo, S. Marinoni, C. E. Martínez-Vázquez, D. Minniti, J. Neeley, S. Otsubo, J. L. Prieto, B. Proxauf, M. Romaniello, N. Sanna, C. Sneden, K. Takenaka, T. Tsujimoto, E. Valenti, C. Yasui, T. Yoshikawa, M. Zoccali   +52 more
openalex   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

The Impact of Initial Composition on Massive Star Evolution and Nucleosynthesis

The Astrophysical Journal
We study the sensitivity of presupernova evolution and supernova nucleosynthesis yields of massive stars to variations of the initial composition. We use the solar abundances from Lodders, and compute two different sets of initial stellar compositions ...
Christopher West, Alexander Heger, Benoit Côté, Lev Serxner, Haoxuan Sun   +4 more
doaj   +1 more source

Determination of Abundances of Chemical Elements in Open Star Clusters of the Galaxy

Open Astronomy, 2016
Spectroscopic determinations of the relative abundances of chemical elements produced in different nuclear-synthesis processes, [el/Fe], are collected for 90 open star clusters of the Galaxy using data from 109 papers published between 1991 and 2015 ...
Gozha M. L., Koval’ V. V., Marsakov V. A.   +2 more
doaj   +1 more source

Glycosylated LGALS3BP is highly secreted by bladder cancer cells and represents a novel urinary disease biomarker

Molecular Oncology, EarlyView.
Urinary LGALS3BP is elevated in bladder cancer patients compared to healthy controls as detected by the 1959 antibody–based ELISA. The antibody shows enhanced reactivity to the high‐mannose glycosylated variant secreted by cancer cells treated with kifunensine (KIF).
Asia Pece, Giulio Lovato, Ilaria Cela, Arianna Mercatelli, Benedetta Ferro, Jussi Nikkola, Sara Pagotto, Tommaso Grottola, Vincenzo De Laurenzi, Rossella Cicchetti, Antonio Marchetti, Luigi Schips, Rossano Lattanzio, Stefano Iacobelli, Emily Capone, Peter Black, Mads Daugaard, Michele Marchioni, Gianluca Sala   +18 more
wiley   +1 more source

Noble Gas Planetology and the Xenon Clouds of Uranus

The Planetary Science Journal
Noble gases provide tracers of cosmic provenance that are accessible to a future Uranus atmospheric probe. Argon and krypton are expected to be well mixed on Uranus with respect to H _2 and He, although condensation at the winter pole may be possible ...
Kevin Zahnle
doaj   +1 more source