Results 61 to 70 of about 7,423,179 (348)

Genetics, drugs and environmental factors in Parkinson's disease: a case-control study Genética, medicamentos e fatores do meio ambiente na doença de Parkinson

Arquivos de Neuro-Psiquiatria, 1999
A case-control study of Parkinson's disease (PD) was conducted in the city of Rio de Janeiro based on the assumption that neurotoxins with secondary parkinsonian action may be related to the development of Parkinson's disease. Ninety-two subjects with PD
ANTONIO LUIZ DOS SANTOS WERNECK, HELCIO ALVARENGA   +1 more
doaj   +1 more source

Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer

FEBS Letters, EarlyView.
Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani, Noemi E. Nwosu, Viktoria Gocke, Müge Kasanmascheff, Hannes Mutschler   +4 more
wiley   +1 more source

Impact of working place on reproduction

Zdravniški Vestnik, 2014
Women of childbearing potential and pregnant women are particularly vulnerable and deserve special attention in terms of occupational safety. Work environment can affect fertility, pregnancy and birth.
Vid Janša, Neva Metelko Janša, Helena Ban Frangež, Marjan Bilban   +3 more
doaj  

Experimental study on thermochemical composite flooding mechanism of extra heavy oil reservoirs with erosion channels

Frontiers in Energy Research
During the steam flooding of extra heavy oil, expansion of steam chamber is difficult and erosion channels appear, which is different from conventional heavy oil.
Qiuying Cao, Haoyu Zheng, Haoyu Zheng, Jianmei Yu, Zanfu Xiong, Zanfu Xiong, Tao Wei, Shuainan Zhu, Shuainan Zhu, Ruixin Liu, Ruixin Liu   +10 more
doaj   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Introduction to chemical warfare agents, relevant simulants and modern neutralisation methods.

Organic and biomolecular chemistry, 2019
Despite international prohibition, some ill-intentioned states and organisations have shown their will and capacity to run chemical weapon programs, and the number of incidents involving chemical warfare agents (CWA) has significantly increased in recent
Baptiste Picard, I. Chataigner, J. Maddaluno, Julien Legros   +3 more
semanticscholar   +1 more source

The role of histone modifications in transcription regulation upon DNA damage

FEBS Letters, EarlyView.
This review discusses the critical role of histone modifications in regulating gene expression during the DNA damage response (DDR). By modulating chromatin structure and recruiting repair factors, these post‐translational modifications fine‐tune transcriptional programmes to maintain genomic stability.
Angelina Job Kolady, Siyao Wang
wiley   +1 more source

Substrate specificity of Burkholderia pseudomallei multidrug transporters is influenced by the hydrophilic patch in the substrate‐binding pocket

FEBS Letters, EarlyView.
Multidrug transporters BpeB and BpeF from the Gram‐negative pathogen Burkholderia pseudomallei have a hydrophilic patch in their substrate‐binding pocket. Drug susceptibility tests and growth curve analyses using an Escherichia coli recombinant expression system revealed that the hydrophilic patches of BpeB and BpeF are involved in the substrate ...
Ui Okada, Satoshi Murakami
wiley   +1 more source

Mechanisms of parasite‐mediated disruption of brain vessels

FEBS Letters, EarlyView.
Parasites can affect the blood vessels of the brain, often causing serious neurological problems. This review explains how different parasites interact with and disrupt these vessels, what this means for brain health, and why these processes matter. Understanding these mechanisms may help us develop better ways to prevent or treat brain infections in ...
Leonor Loira, Sílvia Arroz‐Madeira, Cláudio A. Franco, Sara Silva Pereira   +3 more
wiley   +1 more source

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source