Results 191 to 200 of about 2,829,330 (224)
Ferroptosis: action and mechanism of chemical/drug-induced liver injury
Drug and Chemical Toxicology, 2023 Drug-induced liver injury (DILI) is characterized by hepatocyte injury, cholestasis injury, and mixed injury. The liver transplantation is required for serious clinical outcomes such as acute liver failure. Current studies have found that many mechanisms were involved in DILI, such as mitochondrial oxidative stress, apoptosis, necroptosis, autophagy ...
Li Zeng +8 more
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Chemical Probes for drug-induced Liver Injury Imaging
Future Medicinal Chemistry, 2020 Drug-induced liver injury (DILI) has been a long-standing concern of modern medicine, and the single most frequent reason for drug nonapprovals and postapproval restrictions or withdrawals. Chemical probes for early diagnosis of DILI has triggered a tremendous interest in the field of molecular imaging.
Jiang Tao, Pengfei Rong, Wei Wang
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Toxicology and Applied Pharmacology, 2012 Although estrogen receptor (ER)α agonists, such as estradiol and ethinylestradiol (EE2), cause cholestasis in mice, they also reduce the degree of liver injury caused by hepatotoxicants as well as ischemia-reperfusion. The functional mechanisms of ERα have yet to be elucidated in drug-induced or chemical-induced liver injury.
Yukitaka Yoshikawa +9 more
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Analytical Methods, 2023 By integrating Dynamic Chemical Labelling (DCL) with Luminex xMAP technology, it becomes feasible to analyse miRs through single- and multi-plex assays, as well as to simultaneously analyse proteins and miRs.
Antonio Marín-Romero +1 more
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Pharmacology & Toxicology, 1992 Abstract:We examined the possibility of predicting the extent of hepatic drug‐oxidizing capacity by determination of caffeine, trimethadione and their metabolites in three groups of rats with chemically induced liver injuries. Trimethadione (4 mg/kg) and caffeine (10 mg/kg) were simultaneously administered as two probe drugs.
Einosuke Tanaka +2 more
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Journal of Applied Toxicology, 2013 ABSTRACTDrug‐induced liver injury (DILI) is a major adverse drug reaction that accounts for one‐third of post‐marketing drug withdrawals. Several classifiers for human hepatotoxicity using chemical descriptors with limited prediction accuracies have been published.
Xiangwei Zhu +2 more
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