Results 191 to 200 of about 211,350 (240)

Morin: a promising hepatoprotective agent against drug and chemical-induced liver injury

Naunyn-Schmiedeberg's Archives of Pharmacology
Pandi Anandakumar, N. B. Sen, Vanitha Manickam Kalappan, Vanita Lal   +3 more
semanticscholar   +3 more sources

Simplified Test for Determination of Drug-Oxidizing Capacity in Rats with Chemical-Induced Liver Injury Using Caffeine and Trimethadione as Model Drugs

Pharmacology & Toxicology, 1992
Abstract:We examined the possibility of predicting the extent of hepatic drug‐oxidizing capacity by determination of caffeine, trimethadione and their metabolites in three groups of rats with chemically induced liver injuries. Trimethadione (4 mg/kg) and caffeine (10 mg/kg) were simultaneously administered as two probe drugs.
Einosuke Tanaka, Akio Ishikawa, Shogo Misawa   +2 more
openalex   +4 more sources

Hybrid in silico models for drug‐induced liver injury using chemical descriptors and in vitro cell‐imaging information

Journal of Applied Toxicology, 2013
ABSTRACTDrug‐induced liver injury (DILI) is a major adverse drug reaction that accounts for one‐third of post‐marketing drug withdrawals. Several classifiers for human hepatotoxicity using chemical descriptors with limited prediction accuracies have been published.
Xiang‐Wei Zhu, Alexander Sedykh, Shu‐Shen Liu   +2 more
openalex   +4 more sources

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AI/ML Models to Predict the Severity of Drug-Induced Liver Injury for Small Molecules.

Chemical Research in Toxicology, 2023
Drug-induced liver injury (DILI), believed to be a multifactorial toxicity, has been a leading cause of attrition of small molecules during discovery, clinical development, and postmarketing.
Mohan Rao, V. Nassiri, C. Alhambra, J. Snoeys, F. van Goethem, O. Irrechukwu, M. Aleo, H. Geys, K. Mitra, Y. Will   +9 more
semanticscholar   +1 more source

Unveiling the therapeutic promise of natural products in alleviating drug‐induced liver injury: Present advancements and future prospects

Phytotherapy Research, 2023
Drug‐induced liver injury (DILI) refers to adverse reactions to small chemical compounds, biological agents, and medical products. These reactions can manifest as acute or chronic damage to the liver.
Deepti Singh, M. A. Khan, Hifzur R Siddique   +2 more
semanticscholar   +1 more source

Step towards a hepatotoxicity warning system: Assessment of drug-induced liver injury risk by applying conformal predictions and chemical substructure alerts

Toxicology Letters, 2015
Tobias Noeske, Ernst Ahlberg
openalex   +3 more sources

Evaluation of 3-D bioprinted human liver tissue for assessment drug-induced liver injury across a diverse set of chemical classes

Toxicology Letters, 2017
Jeffrey Irelan, Candace Crogan‐Grundy, Ryan P. Smith, Rhiannon N. Hardwick, Deborah G. Nguyen   +4 more
openalex   +3 more sources

Biochemical and morphological study of the liver injury induced by drugs and chemicals.

Taiwan yi xue hui za zhi. Journal of the Formosan Medical Association, 1979
Lai My, Sung Jl, Lin Ws, How Sw, Yü Jy, Wang Th, Ding‐Shinn Chen   +6 more
openalex   +2 more sources

StackDILI: Enhancing Drug-Induced Liver Injury Prediction through Stacking Strategy with Effective Molecular Representations

Journal of Chemical Information and Modeling
Drug-induced liver injury (DILI) is a major challenge in drug development, often leading to clinical trial failures and market withdrawals due to liver toxicity.
Jiahui Guan, Danhong Dong, Peilin Xie, Zhihao Zhao, Yilin Guo, Tzong-Yi Lee, Lantian Yao, Ying-Chih Chiang   +7 more
semanticscholar   +1 more source

TCN-RDP: Predicting Drug-Induced Liver Injury from Time-Series Toxicogenomic Data.

Journal of Chemical Information and Modeling
Drug-induced liver injury (DILI) is a major obstacle in drug development, often leading to high failure rates in clinical trials. Traditional toxicological assessments are slow and resource-intensive, making early prediction of hepatotoxicity a ...
Zhongyan Zhao, Bin Li, Haochen Zuo, Ruibing Chen, Rui Deng, Jie Geng, Changming Sun, Leyi Wei, Mingxiao Lang, Ran Su   +9 more
semanticscholar   +1 more source