Results 261 to 270 of about 198,086 (334)

Aegeline improves doxorubicin-induced liver toxicity by modulating oxidative stress and Bax/Bcl2/caspase/NF-κB signaling. [PDF]

Sci Rep
Alsahli TG, Alharbi KS, Alenezi SK, Alqahtani R, Afzal M, Sayyed N.   +5 more
europepmc   +1 more source

Liquiritin Exerts a Dual Effect on BMSCs Osteogenic Differentiation and Fracture Healing by Activating the ERK/JNK Pathway and Providing Antioxidant Protection

Advanced Therapeutics, EarlyView.
Liquiritin enhances the osteogenic differentiation of BMSCs and promotes fracture healing through the activation of the ERK/JNK signaling pathway and by exerting antioxidant protective effects. Abstract Liquiritin, a flavonoid from Glycyrrhiza uralensis L., has diverse pharmacological properties, but its impact on fracture healing is unexplored.
Haijun Mao, Jing Liu, Juan Feng, Yalikun Yusufu, Lei Yang, Qing Jiang, Minghui Sun   +6 more
wiley   +1 more source

Co-Assembled Nanoparticles Comprising Sorafenib and Hederagenin Derivative for Enhanced Anti-Hepatic Fibrosis Activity. [PDF]

Int J Nanomedicine
Lu M, Dai Z, Lin Y, Sun C, Li S, Guo Z, Liu Y, Liu X, Li S, Liu R, Xu B, Lei H.   +11 more
europepmc   +1 more source

Microphysiological Systems in Cancer Research: Advancing Immunotherapy through Tumor Microenvironment‐Integrated Organ‐On‐Chip Models

Advanced Therapeutics, EarlyView.
Emerging microphysiological systems reproduce the spatial, biochemical, and cellular complexity of the tumor microenvironment, surpassing 2D cultures and murine models. By integrating patient‐derived tumors, perfusable vasculature, and immune trafficking, these organ‐on‐chip platforms reveal mechanisms of immune evasion, predict therapeutic responses ...
Fabiana Moresi, Francesco Noto, Jyothsna Vasudevan, Xavier Bisteau, Giulia Adriani, Andrea Pavesi   +5 more
wiley   +1 more source

Pharmacological and therapeutic effects of natural products on liver regeneration-a comprehensive research. [PDF]

Chin Med
Tian C, Wang Y, Wang R, Pan L, Xu T.
europepmc   +1 more source

Rewiring Neuroimmunity: Nanoplatform Innovations for CNS Disease Therapy

Advanced Therapeutics, EarlyView.
This review explores emerging nanoplatform strategies designed to modulate neuroimmune responses for treating central nervous system (CNS) disorders. It examines structural and microenvironmental barriers, advances in multifunctional and targeted nanotechnologies, and highlights clinical progress and translational challenges, offering insights into the
Muhammad Usman Akbar, Weiwei Guo, Xin Shen, Yimeng Fang, Yilin Liu, Peng‐Yuan Wang, Roey Elnathan, Yaping Chen   +7 more
wiley   +1 more source

Hepatotoxicity evaluation method through multiple-factor analysis using human pluripotent stem cell derived hepatic organoids. [PDF]

Sci Rep
Shin DS, Yang JY, Jeong HN, Mun SJ, Kim H, Son MJ, Bae MA.   +6 more
europepmc   +1 more source

Genetic Engineering Methods in Primary T Cells

Advanced Therapeutics, EarlyView.
Primary T cells can be engineered to confer them with novel therapeutic functions, allowing them to treat a variety of conditions. Genetic engineering can be either stable or transient, aiming to either express or inhibit a target gene. This review discusses the various genetic engineering tools available as well as their characteristics and ...
Anthony Youssef, Hui‐Shan Li
wiley   +1 more source

GPR35 prevents drug-induced liver injury via the Gαs-cAMP-PKA axis in macrophages. [PDF]

Cell Mol Life Sci
Zhao X, Li Y, Yang L, Chen X, Zhang J, Chen T, Wang H, Li F, Cheng C, Wu J, Cong J, Yin W, Li J, Wang X.   +13 more
europepmc   +1 more source

Evolution of Ocular Organ‐On‐Chip Systems for Disease Modelling and Drug Testing: Where are We Now?

Advanced Therapeutics, EarlyView.
The rise in ophthalmic diseases due to aging, screen use, and environmental factors has driven demand for better ocular models. Traditional systems fall short, encouraging the development of organ‐on‐chip devices. These microfluidic platforms replicate eye tissue architecture, enable drug screening, and simulate ocular diseases.
Sara Trujillo
wiley   +1 more source