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Definition of the Chemical and Immunological Signals Involved in Drug-Induced Liver Injury
Chemical Research in Toxicology, 2019 Idiosyncratic drug-induced liver injury (iDILI), which is rare and often recognized only late in drug development, poses a major public health concern and impediment to drug development due to its high rate of morbidity and mortality.
Serat-E Ali +3 more
semanticscholar +5 more sources
Analytical Methods, 2023 Drug-Induced Liver Injury (DILI) is a grave global adverse event that can result in fatal consequences, causing drug failures, market withdrawals, and regulatory warnings, leading to substantial financial losses.
Antonio Marín-Romero +1 more
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Toxicology and Applied Pharmacology, 2012 Although estrogen receptor (ER)α agonists, such as estradiol and ethinylestradiol (EE2), cause cholestasis in mice, they also reduce the degree of liver injury caused by hepatotoxicants as well as ischemia-reperfusion. The functional mechanisms of ERα have yet to be elucidated in drug-induced or chemical-induced liver injury.
Yukitaka Yoshikawa +9 more
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Chemical modification and signalling of redox-sensitive transcription factors in the adaptive response to drug-induced liver injury [PDF]
, 2011 Alvin J. L. Chia
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Machine Learning-Based Approach for Predicting Drug-Induced Liver Injury of Chemical Compounds
Journal of KIISE, 2023 Soyeon Lee, Sunyong Yoo
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AI/ML Models to Predict the Severity of Drug-Induced Liver Injury for Small Molecules.
Chemical Research in Toxicology, 2023Drug-induced liver injury (DILI), believed to be a multifactorial toxicity, has been a leading cause of attrition of small molecules during discovery, clinical development, and postmarketing.
Mohan Rao +9 more
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Pharmacology & Toxicology, 1992 Abstract:We examined the possibility of predicting the extent of hepatic drug‐oxidizing capacity by determination of caffeine, trimethadione and their metabolites in three groups of rats with chemically induced liver injuries. Trimethadione (4 mg/kg) and caffeine (10 mg/kg) were simultaneously administered as two probe drugs.
Einosuke Tanaka +2 more
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Phytotherapy Research, 2023
Drug‐induced liver injury (DILI) refers to adverse reactions to small chemical compounds, biological agents, and medical products. These reactions can manifest as acute or chronic damage to the liver.
Deepti Singh +2 more
semanticscholar +1 more source
Drug‐induced liver injury (DILI) refers to adverse reactions to small chemical compounds, biological agents, and medical products. These reactions can manifest as acute or chronic damage to the liver.
Deepti Singh +2 more
semanticscholar +1 more source
Journal of Applied Toxicology, 2013 ABSTRACTDrug‐induced liver injury (DILI) is a major adverse drug reaction that accounts for one‐third of post‐marketing drug withdrawals. Several classifiers for human hepatotoxicity using chemical descriptors with limited prediction accuracies have been published.
Xiangwei Zhu +2 more
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