Results 71 to 80 of about 92,867 (160)

Supervised chemical graph mining improves drug-induced liver injury prediction

, 2022
Sangsoo Lim, Young‐Kuk Kim, Jeonghyeon Gu, Sunho Lee, Wonseok Shin, Sun Kim   +5 more
openalex   +1 more source

Correlation between Kupffer Cell Infiltration and Liver Parenchymal Cell Damages in Immunosuppressed Drugs-Induced Rats

Majalah Kedokteran Bandung
The liver is the largest organ in the body, composed of both parenchymal and non-parenchymal cells. Chemical substances and various drugs can induce liver injury and involve Kupffer cells which are non-parenchymal cells that release biologically active ...
Agni Febrina Pargaputri, Endah Wahjuningsih, Dwi Andriani   +2 more
doaj   +1 more source

Identification of average molecular weight (AMW) as a useful chemical descriptor to discriminate liver injury-inducing drugs

, 2021
Yuki Shimizu, Takamitsu Sasaki, Jun‐ichi Takeshita, Michiko WATANABE, Ryota Shizu, Takuomi Hosaka, Kouichi Yoshinari   +6 more
openalex   +2 more sources

Hepatotoxicity of antipsychotics: an exploratory pharmacoepidemiologic and pharmacodynamic study integrating FAERS data and in vitro receptor-binding affinities

Frontiers in Psychiatry
IntroductionAntipsychotic psychopharmacotherapy is associated with the risk of drug-induced liver injury (DILI). However, understanding specific risk factors remains challenging due to limited data.
René Zeiss, Carlos Schönfeldt-Lecuona, Bernhard J. Connemann, Susanne Hafner, Maximilian Gahr   +4 more
doaj   +1 more source

Alpinetin pretreatment prevents lipopolysaccharide/D-galactosamine-induced acute liver injury in mice by inhibiting ferroptosis via the Nrf2/SLC7A11/GPX4 pathway

Scientific Reports
This study aims to investigate whether alpinetin prevents lipopolysaccharide/D-galactosamine (LPS/D-GalN)-induced acute liver injury (ALI) in mice by inhibiting ferroptosis, and to explore the potential molecular mechanisms involved. Thirty-six male BALB/
Yujia Liu, Jiayue Zhao, Weihong Cong, Tonggang Liu, Kaihui Sha   +4 more
doaj   +1 more source

Machine learning-assisted analysis of serum metabolomics for identifying biomarkers in intrinsic and idiosyncratic drug-induced liver injury. [PDF]

Front Pharmacol
Wei X, Wei J, Huang Y, Lian S.
europepmc   +1 more source

Atorvastatin-Associated Liver Injury: Outcome After Statin Rechallenge. [PDF]

Fundam Clin Pharmacol
Bertin B, Lacotte V, Cracowski JL, Gaiffe A, Dumortier J, Vial T.   +5 more
europepmc   +1 more source

Bioactive manganese oxide nanoassembly as a highly sensitive magnetic resonance imaging probe for grading diagnosis of liver injury. [PDF]

J Nanobiotechnology
Yang N, Wang C, Wang J, Xia J, Cao Q, Cao H, Wang Y, Bo C, Ge S, Sun C, Cai Z, Lin H, Liu K.   +12 more
europepmc   +1 more source

Insights into the Biochemical and Immune Mechanisms in Drug-Induced Liver Injury Pathogenesis. [PDF]

Chem Res Toxicol
Saville E, Wells G, Farrell L, Naisbitt DJ, Meng X.   +4 more
europepmc   +1 more source

Diagnostic value of drug withdrawal observation in drug-induced liver injury: A retrospective study. [PDF]

Medicine (Baltimore)
Liu YH, Guo Y, Xu H, Han Y, Feng H, Pan F.   +5 more
europepmc   +1 more source