Results 101 to 110 of about 545,592 (346)

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

A framework for empirical discovery [PDF]

, 1986
Previous research in machine learning has viewed the process of empirical discovery as search through a space of 'theoretical' terms. In this paper, we propose a problem space for empirical discovery, specifying six complementary operators for defining ...
Langley, Pat, Nordhausen, Bernd
core   +1 more source

Plasma extrachromosomal circular DNA as a biomarker in EGFR‐targeted therapy of non‐small cell lung cancer

Molecular Oncology, EarlyView.
Detection of extrachromosomal circular DNA (eccDNA) in plasma samples from EGFR‐mutated non‐small cell lung cancer patients. Plasma was collected before and during treatment with the EGFR‐tyrosine kinase inhibitor osimertinib. Plasma eccDNA was detected in all cancer samples, and the presence of the EGFR gene on eccDNA serves as a potential biomarker ...
Simone Stensgaard, Sarmad Mehmood, Eva Boysen Fynboe Ebert, Peter Meldgaard, Anindya Dutta, Boe S. Sorensen   +5 more
wiley   +1 more source

IMPACT OF SLOW DRYING IN A COLD ROOM ON COFFEE SENSORY, CHEMICAL, AND PHYSICAL PROPERTIES [PDF]

Engenharia Agrícola
This study aimed to evaluate the duplicity and synergism of slow drying and storage processes at low temperatures, using a refrigerated room under suitable conditions for coffee fruit just after harvest.
Rodrigo A. Jordan, Fabrício C. de Oliveira, Eliana J. S. Argandoña, Anamari V. A. Motomiya, Rodrigo C. Santos   +4 more
doaj   +1 more source

Soil chemical attributes in a high biodiversity silvopastoral system

Acta Agronómica, 2018
The use of conservation managements such as the silvopastoral system, and the Voisin rational grazing system have been excellent alternatives to increase animal welfare and production efficiency and improve soil chemical attributes of degraded pastures. Therefore, the objective of this work was to evaluatethe effect of a High Biodiversity Silvopastoral
Luiz Fernando Zin Battisti, Abdon Luiz Schmitt Filho, Arcângelo Loss, Paulo Antonio De Almeida Sinisgalli   +3 more
openaire   +2 more sources

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Variability in morphological and physico-chemical traits of aonla (Emblica officinalis) genotypes collected from north-eastern region of India

The Indian Journal of Agricultural Sciences, 2016
Wild aonla (Emblica officinalis Gaertn.) is found growing throughout the north eastern region of India. An extensive survey was made to identify and collect the elite genotypes at different altitude to determine variability for physical and biochemical ...
A K SINGH, P P SINGH, SANJAY SINGH, R BHARGAVA, PURNIMA MAKWANA   +4 more
doaj   +1 more source

Pomological and Chemical Attributes of Almond Genotypes Selected from Hatay Province

Uluslararası Tarım ve Yaban Hayatı Bilimleri Dergisi, 2019
This study was conducted to determine some pomological and chemical characteristics of 19 almond genotypes in term of found to be promising in yield and quality attributes. Selected from natural almond populations of Hatay province and district (Belen, Antakya, Yayladağı, Altınözü, Hassa) and shelled fruit weights of selected promising genotypes varied
Ahmet SÜMBÜL, Safder BAYAZİT
openaire   +2 more sources