Results 61 to 70 of about 323,700 (316)

Longterm dynamics of prior pollutants concentration and total level of chemical contamination in the coastal areas at Vladivostok (Peter the Great Bay, Japan Sea)

open access: yesИзвестия ТИНРО, 2020
Contents of hydrocarbons, phenols, DDT and its metabolites, Cu, Pb, DDD/DDE and DDD+DDE/DDT ratios, and total level of chemical contamination (TPF index) in bottom sediments are traced for 16 stations in the coastal areas at Vladivostok in 1982−2018. The
A. V. Moshchenko   +4 more
doaj   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

open access: yesMolecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat   +8 more
wiley   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

open access: yesMolecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson   +9 more
wiley   +1 more source

The epidemiology of chemical contaminants of drinking water [PDF]

open access: yesFood and Chemical Toxicology, 2000
A number of chemical contaminants have been identified in drinking water. These contaminants reach drinking water supplies from various sources, including municipal and industrial discharges, urban and rural run-off, natural geological formations, drinking water distribution materials and the drinking water treatment process.
openaire   +2 more sources

Nitrate Contamination in Groundwater: Evaluating the Effects of Demographic Aging and Depopulation in an Island with Intensive Citrus Cultivation

open access: yes, 2022
Despite rapid population aging and depopulation in Japan, groundwater nitrate contamination still poses serious environmental problems. One of the main factors contributing to elevated nitrate levels in Japanese groundwater sources is agricultural ...
Mitsuyo Saito   +6 more
core   +1 more source

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

open access: yesMolecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos   +6 more
wiley   +1 more source

Extraction and analysis of pharmaceutical residues in environmental samples using SPE with LC-MS/MS [PDF]

open access: yes, 2007
Pharmaceuticals and personal care products (PPCPs) have recently emerged as a significant new class of organic micro-contaminants. Of recent years a number of reports detailing the presence of PPCPs in a variety of environmental matrices and compartments
Bones, John-Joseph
core  

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

open access: yesMolecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen   +11 more
wiley   +1 more source

Water contamination reduces the tolerance of coral larvae to thermal stress [PDF]

open access: yes, 2010
Coral reefs are highly susceptible to climate change, with elevated sea surface temperatures (SST) posing one of the main threats to coral survival.
Negri Andrew P.   +9 more
core   +1 more source

A Review of Groundwater Contamination in West Bank, Palestine: Quality, Sources, Risks, and Management

open access: yes, 2022
The contamination and shortages of drinking water in the West Bank are among the most important challenges facing the Palestinian National Authority (PA) and the population residing in all sectors.
Ashraf Zohud, Lubna Alam
core   +1 more source

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