Results 81 to 90 of about 323,700 (316)

Integrated Chemical and Ecotoxicological Assessment of Metal Contamination in the Andong Watershed: Identifying Key Toxicants and Ecological Risks

This study employed an integrated field monitoring approach, combining chemical analysis and ecotoxicity testing of multiple environmental matrices—water, sediment, and sediment elutriates—to comprehensively assess the environmental health of
Chankook Kim, Mansik Choi, Jiwoong Chung, Dae-sik Hwang, Seong-Dae Moon, Jong-Hyeon Lee, Chan-Gyoung Sung, Su-Hyun Kim   +7 more
core   +1 more source

The Need and Potential of Biosensors to Detect Dioxins and Dioxin-Like Polychlorinated Biphenyls along the Milk, Eggs and Meat Food Chain

, 2011
Dioxins and dioxin-like polychlorinated biphenyls (DL-PCBs) are hazardous toxic, ubiquitous and persistent chemical compounds, which can enter the food chain and accumulate up to higher trophic levels.
de Boer, I.J.M., Meerburg, B.G., Chobtang, Jeerasak, Boer, I.J.M., de, Imke J. M. De Boer, Aize Kijlstra, Jeerasak Chobtang, Kijlstra, Aize, Haasnoot, Willem, Hoogenboom, L.A.P., de Boer, Imke J. M., Meerburg, Bastiaan G., Hoogenboom, Ron L. A. P., Willem Haasnoot, Haasnoot, W., Bastiaan G. Meerburg, Ron L. A. P. Hoogenboom, Chobtang, J., Kijlstra, A.   +18 more
core   +1 more source

Fermentation with Pectin Trans-Eliminase to Reduce Cadmium Levels in Nacional and CCN-51 Cocoa Bean Genotypes

Plants
Cocoa represents a crucial source of income in coastal regions of Ecuador, where the product is exported for the production of high-value chocolates.
Wiston Javier Morales-Rodriguez, Jaime Morante-Carriel, Mercedes Carranza-Patiño, Darko Ormaza-Vásquez, María Concepción Ayuso-Yuste, María Josefa Bernalte-García   +5 more
doaj   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Adaptor protein CIN85 potentiates the motility of osteosarcoma cells via the Akt/mTOR and MMP2‐COL3A1 axis

Molecular Oncology, EarlyView.
CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak, Iva Staniczková Zambo, Matěj Přikryl, Peter Múdry, Danica Zapletalová, Jarmila Navrátilová, Jiří Navrátil, Jan Šmarda, Liudmyla Drobot, Petr Beneš, Lucia Knopfová   +10 more
wiley   +1 more source

Converting rain into drinking water: Quality issues and technological advances

, 2011
With growing pressures on water supplies worldwide, rainwater harvesting is increasingly seen as a viable option to provide drinking water to an ever expanding population, particularly in developing countries.
Hudson-Edwards, KA, Campos, LC, Adler, I., Hudson-Edwards, Karen A., Adler, I, Bai, R., Campos, L., Zhang, L.   +7 more
core   +1 more source

Longitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel

Molecular Oncology, EarlyView.
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena, Karin Teien Lande, Eva Diaz, Ana Vilar, Juan Cueva, Efigenia Arias, Victoria Sampayo, Alicia Abalo, Nerea González, Eva Colás, Antonio Gil‐Moreno, Miguel Abal, Gema Moreno‐Bueno, Therese Sørlie, Kristina Lindemann, Laura Muinelo‐Romay   +15 more
wiley   +1 more source

Water Quality and Microbiological Contamination across the Fish Marketing Chain: A Case Study in the Peruvian Amazon (Lagoon Yarinacocha)

, 2022
The contamination of the surface water of lagoons is a common problem in developing countries, and can affect fishing activities. A case study was conducted on water quality and microbiological contamination of the fishing marketing chain in the Peruvian
Rosa González, Daphne Ramos, Juan Rondón-Espinoza, Cesar M. Gavidia   +3 more
core   +1 more source

Teor e capacidade máxima de adsorção de arsênio em Latossolos brasileiros Content and maximum capacity of arsenic adsorption in Brazilian Oxisols

Revista Brasileira de Ciência do Solo, 2007
A alta toxicidade do As aos animais e humanos e a possibilidade de existência de grande número de áreas contaminadas tornam imprescindível o conhecimento do teor semitotal em solos ditos não-contaminados e dos processos de adsorção do As em solos de ...
Mari Lucia Campos, Luiz Roberto Guimarães Guilherme, Rafael Siqueira Lopes, Alessandra Silveira Antunes, João José Granate de Sá e Melo Marques, Nilton Curi   +5 more
doaj   +1 more source

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source