Results 71 to 80 of about 891,505 (290)

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Fermentation with Pectin Trans-Eliminase to Reduce Cadmium Levels in Nacional and CCN-51 Cocoa Bean Genotypes

Plants
Cocoa represents a crucial source of income in coastal regions of Ecuador, where the product is exported for the production of high-value chocolates.
Wiston Javier Morales-Rodriguez, Jaime Morante-Carriel, Mercedes Carranza-Patiño, Darko Ormaza-Vásquez, María Concepción Ayuso-Yuste, María Josefa Bernalte-García   +5 more
doaj   +1 more source

Assessment of metals behaviour in industrial soil using sequential extraction, multivariable analysis and a geostatistical approach [PDF]

, 2017
The main objectives of this studywere to evaluate the degree of Pb, Cu, Zn, Cd, Cr and Ni pollution using pollution indexes and geostatistical approach, and to assess metals dynamic using sequential extraction procedure and multivariable statistical ...
Acosta Avilés, José Alberto, Faz Cano, Ángel, Gabarrón Sánchez, María, Martínez Martínez, Silvia, Zornoza Belmonte, Raúl   +4 more
core   +2 more sources

Detection of chemical contaminants [PDF]

, 2018
With the financial support of Internal Security Fund Police Programme European Commission Directorate General Home Affairs. This project has been founded with support from the European Commission. This publication reflects the views only of the authors, and European Commission cannot be held responsible for any use which may be made of the information ...
Stela, Maksymilian, Ceremuga, Michał, Szyposzyńska, Monika, Spławska, Aleksandra, Mirosz, Danuta, Truszkowska, Katarzyna   +5 more
openaire   +3 more sources

Feasibility of a ctDNA multigenic panel for non‐small‐cell lung cancer early detection and disease surveillance

Molecular Oncology, EarlyView.
Plasma‐based detection of actionable mutations is a promising approach in lung cancer management. Analysis of ctDNA with a multigene NGS panel identified TP53, KRAS, and EGFR as the most frequently altered, with TP53 and KRAS in treatment‐naïve patients and TP53 and EGFR in previously treated patients.
Giovanna Maria Stanfoca Casagrande, Marcela de Oliveira Silva, Mariana Bisarro dos Reis, Rodrigo de Oliveira Cavagna, Luciane Sussuchi, Icaro Alves Pinto, Natalia Zampieri Pontes, Rodrigo Sampaio Chiarantano, Flavio Augusto Ferreira da Silva, Pedro de Marchi, Letícia Ferro Leal, Rui M. Reis   +11 more
wiley   +1 more source

Book Reviews [PDF]

, 1990
Reviews of the following books prepared by the editors of Risk on the topic of toxic tort litigation and/or public regulation of toxic substances: Frank B.
RISK Editorial Board
core   +1 more source

Agent selection and threat actualization in contamination cases: Predicting action from perpetrator behavior [PDF]

, 2018
While existing research on the topic is sparse, previous works have shown that there is believed to be a substantial threat of intentional, malicious contamination of the supply chain by criminals and terrorists (CFSAN, 2001; WHO, 2008).
Kilbane, Sarah C.
core   +1 more source

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source

Teor e capacidade máxima de adsorção de arsênio em Latossolos brasileiros Content and maximum capacity of arsenic adsorption in Brazilian Oxisols

Revista Brasileira de Ciência do Solo, 2007
A alta toxicidade do As aos animais e humanos e a possibilidade de existência de grande número de áreas contaminadas tornam imprescindível o conhecimento do teor semitotal em solos ditos não-contaminados e dos processos de adsorção do As em solos de ...
Mari Lucia Campos, Luiz Roberto Guimarães Guilherme, Rafael Siqueira Lopes, Alessandra Silveira Antunes, João José Granate de Sá e Melo Marques, Nilton Curi   +5 more
doaj   +1 more source

Chemical contamination and the thyroid

Endocrine, 2014
Industrial chemical contaminants have a variable impact on the hypothalamic-pituitary-thyroid axis, this depending both on their class and on confounding factors. Today, mounting evidence is pointing to the role of environmental factors, and specifically EDCs, in the current distressing upsurge in the incidence of thyroid disease.
openaire   +3 more sources