Results 81 to 90 of about 891,505 (290)

Screening for lung cancer: A systematic review of overdiagnosis and its implications

Molecular Oncology, EarlyView.
Low‐dose computed tomography (CT) screening for lung cancer may increase overdiagnosis compared to no screening, though the risk is likely low versus chest X‐ray. Our review of 8 trials (84 660 participants) shows added costs. Further research with strict adherence to modern nodule management strategies may help determine the extent to which ...
Fiorella Karina Fernández‐Sáenz, Laura de la Torre‐Perez, David R Baldwin, Carlijn van der Aalst, Mangesh Thorat, David Ritchie, Andre L Carvalho, Carolina Espina, Ivan Solà, Carlos Canelo‐Aybar, Moira Magdalena Pissinis, Pablo Alonso‐Coello, Ana Carolina Pereira Nunes Pinto   +12 more
wiley   +1 more source

Impacts of local human activities on the Antarctic environment [PDF]

, 2008
We review the scientific literature, especially from the past decade, on the impacts of human activities on the Antarctic environment. A range of impacts has been identified at a variety of spatial and temporal scales.
Agnew, Agnew, Ainley, Baker, Ballance, Bargagli, Barrera-Oro, Brown, C.A. Moreno, Chen, Clarke, Clarke, Constable, Constable, Constable, Convey, Convey, Convey, Convey, Cooney, Croxall, Croxall, D.G. Ainley, de Leeuw, de Poorter, Delord, DeVries, Duhamel, Edwards, Fraser, Frenot, Gon, Greenslade, Greenslade, Greenslade, Gremmen, Gröndahl, Hansom, Hee, Hemmings, Hofman, Holmes, Hughes, Huiskes, I. Snape, J. Scott, Jones, Jouventin, K.A. Hughes, Kennicutt, Kerry, Knox, Kock, Kock, Kock, Kohnen, Laws, McDonald, Moreno, Morris, Muller-Schwarze, Naveen, Naveen, Nicol, Ohtani, Olech, Otley, P. Convey, Pauly, Pauly, Peter, Pfeiffer, Pfeiffer, Rounsevell, S. Pfeiffer, Salwicka, Sjoling, Sladen, Smith, Smith, Snape, Snape, Summerson, T. Tin, Tejedo, Thor, Trathan, Weimerskirch, Wheeler, Willock, Woehler, Z.L. Fleming   +91 more
core   +2 more sources

Glycosylated LGALS3BP is highly secreted by bladder cancer cells and represents a novel urinary disease biomarker

Molecular Oncology, EarlyView.
Urinary LGALS3BP is elevated in bladder cancer patients compared to healthy controls as detected by the 1959 antibody–based ELISA. The antibody shows enhanced reactivity to the high‐mannose glycosylated variant secreted by cancer cells treated with kifunensine (KIF).
Asia Pece, Giulio Lovato, Ilaria Cela, Arianna Mercatelli, Benedetta Ferro, Jussi Nikkola, Sara Pagotto, Tommaso Grottola, Vincenzo De Laurenzi, Rossella Cicchetti, Antonio Marchetti, Luigi Schips, Rossano Lattanzio, Stefano Iacobelli, Emily Capone, Peter Black, Mads Daugaard, Michele Marchioni, Gianluca Sala   +18 more
wiley   +1 more source

Survivin and Aurora Kinase A control cell fate decisions during mitosis

Molecular Oncology, EarlyView.
Aurora A interacts with survivin during mitosis and regulates its centromeric role. Loss of Aurora A activity mislocalises survivin, the CPC and BubR1, leading to disruption of the spindle checkpoint and triggering premature mitotic exit, which we refer to as ‘mitotic slippage’.
Hana Abdelkabir, Shalitha Wickrama Arachchige, Sally P. Wheatley   +2 more
wiley   +1 more source

Groundwater Contamination [PDF]

This lesson addresses groundwater contamination from leakage of underground gasoline, oil, or other hazardous chemical tanks. Students read two short articles and investigate causes, effects, solutions, and prevention measures.
Christine McLelland
core  

Contamination of surface waters by mining wastes in the Milluni Valley (Cordillera Real, Bolivia): Mineralogical and hydrological influences [PDF]

, 2008
This study is one of very few dealing with mining waste contamination in high altitude, tropical-latitude areas exploited during the last century. Geochemical, mineralogical and hydrological characterizations of potentially harmful elements (PHEs) in ...
Isaure, Marie-Pierre, Probst, Anne, Roulet, Marc, Salvarredy-Aranguren, Matias Miguel   +3 more
core   +3 more sources

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source

2001 Water Symposium: Water Pollution in Urban and Rural Settings [PDF]

, 2001
The Environmental and Energy Study Institute, the Federal Water Quality Association and the National Capital Chapter of the American Water Resources Association co-hosted the 2001 Water Symposium: Water Pollution In Urban And Rural Settings.The symposium
Ron Grandon
core  

Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting

Molecular Oncology, EarlyView.
CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia, Noelia Moares, Wenjie Yi‐He, Rosa Luna‐Espejo, Ricardo Fernandez‐Cisnal, Javier Ocaña‐Cuesta, Juan P. Muñoz‐Miranda, Antonio Gabucio, Cecilia M. Fernandez‐Ponce, Francisco Garcia‐Cozar   +9 more
wiley   +1 more source

Ausencia de detección de enterovirus en bivalvos Anadara tuberculosa (Bivalvia: Arcidae) por contaminación química en el Pacífico de Costa Rica

Revista de Biología Tropical, 1999
Anadara tuberculosa es uno de los moluscos más abundantes de importancia comercial en Costa Rica. Su hábitat acuático es una fuente potencial de contaminación fecal y química para el ser humano.
Libia Herrero U., Alejandro Palacios F., Laya Hun O., Francisco Vega A.   +3 more
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