Results 41 to 50 of about 1,693,931 (265)

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

FEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva, Puspa Kunwar, Md Ibnul Rifat Rahman, Joanna Koryo Kwao, Nathan Lehman, Zihan Zhang, Trenton Paul, Claire Cheng, Nicholas Truex, Hui‐Ting Lee, Jun Zhang   +10 more
wiley   +1 more source

The crystal structure of bepotastine besilate, C27H31ClN2O6S

Zeitschrift für Kristallographie - New Crystal Structures
C27H31ClN2O6S, triclinic, P1 (no. 1), a = 8.0223(3) Å, b = 9.8143(3) Å, c = 10.2307(4) Å, α = 88.308(3)°, β = 69.000(3)°, γ = 65.970(3)°, V = 680.39(5) Å3, Z = 1, R gt(F) = 0.0406, wRref (F 2) = 0.1165, T = 297 K.
Wang Fengfeng, Luan Lin, Hu Xiaowen, Zhang Caiyu, Liu Yang   +4 more
doaj   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

The crystal structure of 3-(7,8-dimethoxy-2-oxo-1,2,4,5-tetrahydro-3H-benzo[d]azepin-3-yl)-N-methylpropan-1-aminium chloride monohydrate, C16H27ClN2O4

Zeitschrift für Kristallographie - New Crystal Structures
C16H27ClN2O4, orthorhombic, Pbca (no. 61), a = 14.8507(3) Å, b = 7.75674(15) Å, c = 31.3294(5) Å, V = 3608.92(11) Å3, Z = 8, Rgt(F) = 0.0406, wRref(F2) = 0.1222, T = 297 K.
Wang Fengfeng, Hu Xiaowen, Zhang Caiyu, Luan Lin, Liu Yang   +4 more
doaj   +1 more source

PICALM::MLLT10 translocated leukemia

FEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen, Antonia C. Nakatsugawa, Natalie Barton, Henry Haines, Gary S. Stein, Janet L. Stein, Daniel S. Wechsler, Jessica L. Heath   +7 more
wiley   +1 more source

The crystal structure of (2-butyl-benzofuran-3-yl)(4-hydroxy-3,5-diiodophenyl)methanone, C19H16I2O3

Zeitschrift für Kristallographie - New Crystal Structures
C19H16I2O3, triclinic, P1̄ (no. 2), a = 8.9049(1) Å, b = 9.1514(1) Å, c = 12.0282(2) Å, α = 101.511(1)°, β = 101.691(1)°, γ = 93.386(1)°, V = 935.49(2) Å3, Z = 2, Rgt(F) = 0.0454, wRref(F2) = 0.1289, T = 297 K.
Wang Fengfeng, Zhang Caiyu, Hu Xiaowen, Luan Lin, Liu Yang   +4 more
doaj   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

The crystal structure of 3,4-dimethoxybicyclo[4.2.0]octa-1(6),2,4-triene-7-carbonitrile, C11H11NO2

Zeitschrift für Kristallographie - New Crystal Structures
C11H11NO2, monoclinic, P21/n (no. 14), a = 8.5089(4) Å, b = 8.2786(4) Å, c = 14.4166(6) Å, β = 105.035(5)°, V = 980.77(8) Å3, Z = 4, Rgt(F) = 0.0505, wRref(F2) = 0.1391, T = 297 K.
Wang Fengfeng, Hu Xiaowen, Zhang Caiyu, Luan Lin, Liu Yang   +4 more
doaj   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

The crystal structure of 4-bromo-2,6-dimethoxybenzaldehyde, C9H9BrO3

Zeitschrift für Kristallographie - New Crystal Structures
C9H9BrO3, monoclinic, C2/c (no. 15), a = 19.8576(5) Å, b = 4.1080(2) Å, c = 23.1284(8) Å, β = 94.983(3)°, V = 1879.57(12) Å3, Z = 8, Rgt(F) = 0.0416, wRref(F2) = 0.1155, T = 297 K.
Wang Fengfeng, Zhang Caiyu, Hu Xiaowen, Luan Lin, Liu Yang   +4 more
doaj   +1 more source