Results 51 to 60 of about 1,834,987 (265)

The crystal structure of bepotastine besilate, C27H31ClN2O6S

Zeitschrift für Kristallographie - New Crystal Structures
C27H31ClN2O6S, triclinic, P1 (no. 1), a = 8.0223(3) Å, b = 9.8143(3) Å, c = 10.2307(4) Å, α = 88.308(3)°, β = 69.000(3)°, γ = 65.970(3)°, V = 680.39(5) Å3, Z = 1, R gt(F) = 0.0406, wRref (F 2) = 0.1165, T = 297 K.
Wang Fengfeng, Luan Lin, Hu Xiaowen, Zhang Caiyu, Liu Yang   +4 more
doaj   +1 more source

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas F. Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

Chemical weed control in carnation transplants

California Agriculture, 1972
Weeds are a problem in transplanted carnations during early stages of development when there can be no soil fumigation or steam sterilization. Early mechanical control of weeds is made impossible by the wire, plastic or bamboo netting that is placed on ...
J Bivins, C Elmore, A Lange
doaj  

The crystal structure of 3-(7,8-dimethoxy-2-oxo-1,2,4,5-tetrahydro-3H-benzo[d]azepin-3-yl)-N-methylpropan-1-aminium chloride monohydrate, C16H27ClN2O4

Zeitschrift für Kristallographie - New Crystal Structures
C16H27ClN2O4, orthorhombic, Pbca (no. 61), a = 14.8507(3) Å, b = 7.75674(15) Å, c = 31.3294(5) Å, V = 3608.92(11) Å3, Z = 8, Rgt(F) = 0.0406, wRref(F2) = 0.1222, T = 297 K.
Wang Fengfeng, Hu Xiaowen, Zhang Caiyu, Luan Lin, Liu Yang   +4 more
doaj   +1 more source

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source

The crystal structure of (2-butyl-benzofuran-3-yl)(4-hydroxy-3,5-diiodophenyl)methanone, C19H16I2O3

Zeitschrift für Kristallographie - New Crystal Structures
C19H16I2O3, triclinic, P1̄ (no. 2), a = 8.9049(1) Å, b = 9.1514(1) Å, c = 12.0282(2) Å, α = 101.511(1)°, β = 101.691(1)°, γ = 93.386(1)°, V = 935.49(2) Å3, Z = 2, Rgt(F) = 0.0454, wRref(F2) = 0.1289, T = 297 K.
Wang Fengfeng, Zhang Caiyu, Hu Xiaowen, Luan Lin, Liu Yang   +4 more
doaj   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source