Results 101 to 110 of about 602,274 (295)

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

On the Origin of Abundance Variations in the Milky Way’s High-α Plateau

The Astrophysical Journal
Using multielement abundances from the Sloan Digital Sky Survey APOGEE survey, we investigate the origin of abundance variations in Milky Way (MW) disk stars on the “high- α plateau,” with −0.5 ≤ [Mg/H] ≤  −0.1 and 0.25 ≤ [Mg/Fe] ≤ 0.35. The elevated [ α
Tawny Sit, David H. Weinberg, Emily J. Griffith   +2 more
doaj   +1 more source

Global profiling of arginine dimethylation in regulating protein phase separation by a steric effect-based chemical-enrichment method. [PDF]

Proc Natl Acad Sci U S A, 2022
Wang Q, Li Z, Zhang S, Li Y, Wang Y, Fang Z, Ma Y, Liu Z, Zhang W, Li D, Liu C, Ye M.   +11 more
europepmc   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Chemical Cartography with APOGEE: Two-process Parameters and Residual Abundances for 288,789 Stars from Data Release 17

The Astrophysical Journal
Stellar abundance measurements are subject to systematic errors that induce extra scatter and artificial correlations in elemental abundance patterns. We derive empirical calibration offsets to remove systematic trends with surface gravity $\mathrm{log ...
Tawny Sit, David H. Weinberg, Adam Wheeler, Christian R. Hayes, Sten Hasselquist, Thomas Masseron, Jennifer Sobeck   +6 more
doaj   +1 more source

Environmental imprint on galaxy chemical enrichment

, 2012
Recent results are presented on the metal enrichment of low-mass star-forming (SF) galaxies in local Universe clusters. The environmental effects on the chemical evolution of these galaxies are discussed. We have used spectroscopic data from the SDSSIII-DR8 and we have derived the gas-phase O/H and N/O abundances.
Petropoulou, Vasiliki, Vilchez, Jose Manuel, Iglesias-Paramo, Jorje   +2 more
openaire   +2 more sources

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

The Development of Ethnoscience-Based Chemical Enrichment Book as a Science Literacy

IJCER (International Journal of Chemistry Education Research), 2018
: This study aims to examine the characteristics and quality of chemical enrichment books based on ethnosciences as a source of science literacy learners. The research method used is Research and Development.
Mariana Fitria, Asih Widi Wisudawati
doaj   +1 more source

V453 Oph: a s-process enriched, but carbon-deficient RV Tauri star of low intrinsic metallicity

, 2005
This paper reports the detection of a heavy element enriched RV Tauri variable with an abundance pattern that differs significantly from a standard s-process enriched object: V453 Oph.
Alcock, Aoki, Aoki, Biémont, Bloecker, Boesgaard, Burris, Cowan, De Ruyter, Evans, François, Gallino, Gehrz, Giridhar, Giridhar, Goldsmith, Gonzalez, Goriely, Gratton, Gratton, H. Van Winckel, Hibbert, Hibbert, Josafatsson, Jura, Krełowski, Kupka, L. Siess, Lambert, Lawler, Lawler, M. Reyniers, Maas, Mathis, McClure, P. Deroo, Palmeri, Preston, Queloz, Reyniers, S. Goriely, Simmerer, Sneden, Thévenin, Tsujimoto, Van Eck, Van Winckel, Van Winckel, Van Winckel, Van Winckel, Van Winckel, Wallerstein, Wallerstein, Waters   +53 more
core   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source