Results 111 to 120 of about 602,274 (295)

The Rise of the r-process in the Gaia-Sausage/Enceladus Dwarf Galaxy

The Astrophysical Journal
Neutron star mergers (NSMs) produce r -process elements after a time-delayed inspiral process. Once a significant number of NSMs are present in a galaxy, r -process elements, such as Eu, are expected to significantly increase with time.
Xiaowei Ou, Alexander P. Ji, Anna Frebel, Rohan P. Naidu, Guilherme Limberg   +4 more
doaj   +1 more source

The effects of stellar winds of fast-rotating massive stars in the earliest phases of the chemical enrichment of the Galaxy

, 2010
We use the growing data sets of very-metal-poor stars to study the impact of stellar winds of fast rotating massive stars on the chemical enrichment of the early Galaxy.
Beers, C. Chiappini, Cayrel, Cescutti, Charbonnel, Chiappini, Chiappini, Chiappini, Christlieb, Christlieb, Collet, Ekström, Fabbian, François, Frebel, Frebel, Frebel, G. Cescutti, Heger, Hirschi, Israelian, Iwamoto, Lai, Maeder, Masseron, Matteucci, Matteucci, Meynet, Meynet, Nissen, Norris, Pipino, Scalo, Schneider, Spite, Spite, Woosley   +36 more
core   +1 more source

Crucial parameters for precise copy number variation detection in formalin‐fixed paraffin‐embedded solid cancer samples

Molecular Oncology, EarlyView.
This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris, Vasiliki Siozopoulou, Léon C van Kempen, Anne Sieben, Ella Roelant, Stig Hellemans, Elyne Backx, Laure Sorber, Koen De Winne, Senada Koljenović, Karen Zwaenepoel   +10 more
wiley   +1 more source

Metal-poor Star-forming Clumps in Cosmic Noon Galaxies: Evidence for Gas Inflow and Chemical Dilution Using JWST NIRISS

The Astrophysical Journal
The formation and evolution of galaxies are intricately linked to the baryon cycle, which fuels star formation while shaping chemical abundances within galaxies.
Vicente Estrada-Carpenter, Marcin Sawicki, Roberto Abraham, Yoshihisa Asada, Maruša Bradač, Gabe Brammer, Guillaume Desprez, Kartheik G. Iyer, Nicholas S. Martis, Adam Muzzin, Gaël Noirot, Gregor Rihtaršič, Ghassan T. E. Sarrouh, Chris J. Willott, Jeremy Favaro, Vladan Markov, Rosa M. Mérida, Katherine Myers, Visal Sok   +18 more
doaj   +1 more source

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon, Rui P. L. Neves, Nikolas H. Stoecklein, Sven‐Thorsten Liffers, Jens Siveke, Jan D. Kuhlmann, Pauline Wimberger, Paul Buderath, Rainer Kimmig, Sabine Kasimir‐Bauer   +9 more
wiley   +1 more source

Tumor mutational burden as a determinant of metastatic dissemination patterns

Molecular Oncology, EarlyView.
This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal, Andrea Moreno‐Manuel, Miguel Salvadó‐Pertierra, Cristina Santos‐Vivas, Rebeca Sanz‐Pamplona   +4 more
wiley   +1 more source

Rapid Chemical Enrichment by Intermittent Star Formation in GN-z11

The Astrophysical Journal Letters
We interpret the peculiar supersolar nitrogen abundance recently reported by the James Webb Space Telescope observations for GN-z11 ( z = 10.6) using our state-of-the-art chemical evolution models.
Chiaki Kobayashi, Andrea Ferrara
doaj   +1 more source

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

Unveiling Galaxy Chemical Enrichment Mechanisms Out to z ∼ 8 from Direct Determination of O and Ar Abundances from JWST/NIRSPEC Spectroscopy

The Astrophysical Journal Letters
Galaxy chemical enrichment mechanisms have primarily been constrained by [ α /Fe] and [Fe/H] measurements of individual stars and integrated light from stellar populations. However, such measurements are limited at higher redshifts ( z  > 1).
Souradeep Bhattacharya, Magda Arnaboldi, Ortwin Gerhard, Chiaki Kobayashi, Kanak Saha   +4 more
doaj   +1 more source

Chemical Yields from the First Stars

, 1999
We examine the dependence of stellar yields on the metallicity Z of the stellar population. This effect may be important for the very first chemical enrichment from Population III stars, at very low Z.
Portinari, L.
core   +2 more sources