Results 111 to 120 of about 6,312,097 (300)

On the Importance of the Intergalactic and Circumgalactic Medium Enrichment in Determining Chemical Abundances during the First 600 Myr

The Astrophysical Journal
JWST observations show that galaxies at z  > 8 exhibit a wide range of carbon-to-oxygen (C/O) ratios at fixed metallicity and systematically elevated nitrogen-to-oxygen (N/O) ratios compared to local galaxies.
Annalisa Citro, Yong-Zhong Qian, Claudia M. Scarlata   +2 more
doaj   +1 more source

Unlocking the potential of cell‐permeable nanobodies for intracellular applications

FEBS Letters, EarlyView.
This review outlines current strategies for delivery of nanobodies into cells and highlights recent examples of functional applications. By addressing and manipulating intracellular targets, these molecules hold great potential for treating cancer, respiratory diseases and neurological disorders, making this a vibrant area of research in the biomedical
Mariona Gené‐Verdés, Luise Franz, Christian P.R. Hackenberger   +2 more
wiley   +1 more source

The Rise of the r-process in the Gaia-Sausage/Enceladus Dwarf Galaxy

The Astrophysical Journal
Neutron star mergers (NSMs) produce r -process elements after a time-delayed inspiral process. Once a significant number of NSMs are present in a galaxy, r -process elements, such as Eu, are expected to significantly increase with time.
Xiaowei Ou, Alexander P. Ji, Anna Frebel, Rohan P. Naidu, Guilherme Limberg   +4 more
doaj   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Metal-poor Star-forming Clumps in Cosmic Noon Galaxies: Evidence for Gas Inflow and Chemical Dilution Using JWST NIRISS

The Astrophysical Journal
The formation and evolution of galaxies are intricately linked to the baryon cycle, which fuels star formation while shaping chemical abundances within galaxies.
Vicente Estrada-Carpenter, Marcin Sawicki, Roberto Abraham, Yoshihisa Asada, Maruša Bradač, Gabe Brammer, Guillaume Desprez, Kartheik G. Iyer, Nicholas S. Martis, Adam Muzzin, Gaël Noirot, Gregor Rihtaršič, Ghassan T. E. Sarrouh, Chris J. Willott, Jeremy Favaro, Vladan Markov, Rosa M. Mérida, Katherine Myers, Visal Sok   +18 more
doaj   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

High-Quality Predicted Metabolite-Pathway Annotations Expand Pathway Coverage and Increase Enriched Pathway Detection Across Metabolomics Datasets

Metabolites
Background/Objectives: Metabolism-level interpretation of metabolomics datasets requires aggregation analyses across metabolites. One highly used aggregation analysis is pathway enrichment analysis (PEA), which involves detecting pathways enriched with ...
Erik D. Huckvale, P. Travis Thompson, Robert M. Flight, Hunter N. B. Moseley   +3 more
doaj   +1 more source

Chemical Literature

, 1969
Quarterly supplement for "the regular journals of the American Chemical Society," containing annotated bibliographies of chemical documentation literature as well as information about meetings, conferences, awards, scholarships, and other news from the ...
American Chemical Society. Division of Chemical Literature.
core  

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

Molecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera, Laura Vela‐Martín, Pablo Fernández‐Navarro, José Luis López‐Lorenzo, Javier Cornago, Pilar Llamas, Eduardo Pérez‐Gómez, José Luis Marín‐Rubio, Manuel Fresno, Javier Santos, José Fernández‐Piqueras, María Villa‐Morales   +11 more
wiley   +1 more source

Metal-poor Gas Accretion Drives Giant Clump Formation at 0.6 < z < 2.6

The Astrophysical Journal
The physical properties of kiloparsec-scale clumps in high-redshift star-forming galaxies (SFGs) contain crucial constraints on how they assemble. Building on recent work that indicates the presence of a metallicity offset in clumpy galaxies compared to ...
Visal Sok, Adam Muzzin, Ben Forrest, Gillian Wilson, Jialu Chen, Vivian Yun Yan Tan, Sunna Withers, Roberto Abraham, Maruša Bradač, Vicente Estrada-Carpenter, Kartheik G. Iyer, Nicholas S. Martis, Gaël Noirot, Ghassan T. E. Sarrouh, Marcin Sawicki, Chris J. Willott, Aurélien Henry, Naadiyah Jagga, Danilo Marchesini, Ian McConachie, Katherine Myers, Nelson Nunes, Luke Robbins   +22 more
doaj   +1 more source