Results 121 to 130 of about 602,274 (295)

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

Chemical Self-Enrichment of HII Regions by the Wolf-Rayet Phase of an 85 Msun star

, 2006
It is clear from stellar evolution and from observations of WR stars that massive stars are releasing metal-enriched gas through their stellar winds in the Wolf-Rayet phase.
Abbott, Anders, Chiosi, D. Kröger, Dray, Dray, Esteban, Freyer, Freyer, G. Hensler, Hirschi, Hirschi, Kunth, Schaller, T. Freyer   +14 more
core   +1 more source

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source

Metallicities from High-resolution TRES Spectra with uberMS: Performance Benchmarks and Literature Comparison

The Astrophysical Journal Supplement Series
As the field of exoplanetary astronomy has matured, demand has grown for precise stellar abundances to probe subtle correlations between stellar compositions and planetary demographics.
Emily K. Pass, Phillip A. Cargile, Victoria DiTomasso, Romy Rodríguez Martínez, David Charbonneau, David W. Latham, Andrew Vanderburg, Allyson Bieryla, Samuel N. Quinn, Lars A. Buchhave   +9 more
doaj   +1 more source

Evaluating the wettability of coal and non-coal mineral particles by microcalorimetry

Fuel Processing Technology
The surface wettability of coal and non-coal minerals is one of the critical factors influencing their separation and processing. In this study, ten common coal and non-coal minerals were selected to analyze the quantitative relationship between their ...
Chengping Deng, Zhongzheng Wu, Teng He, Yuqiang Mao, Liuyang Dong, Dianwen Liu   +5 more
doaj   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

Identifying ∼20,000 Li-rich Giants in the LAMOST Low-resolution Survey

The Astrophysical Journal Supplement Series
Li-rich giants serve as valuable tracers of stellar evolution and surface enrichment processes, for which a statistically large and homogeneous sample is crucial. Using the massive low-resolution ( R  ∼ 1800) spectroscopic dataset from the Large Sky Area
Ming-Yi Ding, Liang Wang, Jian-Rong Shi, Hong-Liang Yan, Chun-Qian Li, Jing Chen, Kai Zhang, Yu-Lu Liang, Zi-Chong Zhang, Xu-Hang Yin, Qin-Yang Dong   +10 more
doaj   +1 more source

Ethno-STEM-Integrated Enriched Chemistry Book to Equip Chemical and Numeracy Literacy

Journal of Innovation in Educational and Cultural Research
Students in Indonesia face chemical literacy and numeracy challenges, which are essential for understanding scientific concepts and solving real-world problems.
Amroeni Rosyada, Woro Sumarni, Murbangun Nuswowati, Ade Noorliza Niyamae   +3 more
doaj   +1 more source

Identification of serum protein biomarkers for pre‐cancerous lesions associated with pancreatic ductal adenocarcinoma

Molecular Oncology, EarlyView.
This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns, Jaclyn S. Long, Sergio Lilla, Kelly Hodge, Marcus J. G. W. Ladds, Colin Nixon, Paula Fernández‐Palanca, Sara Zanivan, Pilar Acedo, Stephen P. Pereira, Kevin M. Ryan   +10 more
wiley   +1 more source

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

Molecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel, Peyman Zarrineh, Nathnael T. Tuffa, Jigar H. Sheth, Sumitra Mohan, Mudassar Iqbal, Sankari Nagarajan   +6 more
wiley   +1 more source