Results 121 to 130 of about 6,312,097 (300)

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Rapid Chemical Enrichment by Intermittent Star Formation in GN-z11

The Astrophysical Journal Letters
We interpret the peculiar supersolar nitrogen abundance recently reported by the James Webb Space Telescope observations for GN-z11 ( z = 10.6) using our state-of-the-art chemical evolution models.
Chiaki Kobayashi, Andrea Ferrara
doaj   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

Molecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner, Pierre Tennstedt, Randi C. Pose, Christian Müller, Katharina Besler, Svenja Schneegans, Malik Alawi, Marie C. Roesch, Sven Peine, Desiree Bonci, Joanna Budna‐Tukan, Evi Lianidou, Catherine Alix‐Panabières, Derya Tilki, Klaus Pantel   +14 more
wiley   +1 more source

Chemical Literature

, 1961
Quarterly supplement for "the regular journals of the American Chemical Society," containing annotated bibliographies of chemical documentation literature as well as information about meetings, conferences, awards, scholarships, and other news from the ...
American Chemical Society. Division of Chemical Literature., Igelsrud, Iver   +1 more
core   +2 more sources

Unveiling Galaxy Chemical Enrichment Mechanisms Out to z ∼ 8 from Direct Determination of O and Ar Abundances from JWST/NIRSPEC Spectroscopy

The Astrophysical Journal Letters
Galaxy chemical enrichment mechanisms have primarily been constrained by [ α /Fe] and [Fe/H] measurements of individual stars and integrated light from stellar populations. However, such measurements are limited at higher redshifts ( z  > 1).
Souradeep Bhattacharya, Magda Arnaboldi, Ortwin Gerhard, Chiaki Kobayashi, Kanak Saha   +4 more
doaj   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Metallicities from High-resolution TRES Spectra with uberMS: Performance Benchmarks and Literature Comparison

The Astrophysical Journal Supplement Series
As the field of exoplanetary astronomy has matured, demand has grown for precise stellar abundances to probe subtle correlations between stellar compositions and planetary demographics.
Emily K. Pass, Phillip A. Cargile, Victoria DiTomasso, Romy Rodríguez Martínez, David Charbonneau, David W. Latham, Andrew Vanderburg, Allyson Bieryla, Samuel N. Quinn, Lars A. Buchhave   +9 more
doaj   +1 more source

Chemical enrichment of the Perseus cluster core seen by XRISM/Resolve

Astronomy & Astrophysics
Context. The intracluster medium (ICM) is rich in chemical elements, produced by core-collapse (SNcc) and Type Ia supernovae (SNIa) over the last ∼12 Gyr.
Audard Marc, Awaki Hisamitsu, Ballhausen Ralf, Bamba Aya, Behar Ehud, Boissay-Malaquin Rozenn, Brenneman Laura, Brown Gregory V., Corrales Lia, Costantini Elisa, Cumbee Renata, Trigo Maria Diaz, Done Chris, Dotani Tadayasu, Ebisawa Ken, Eckart Megan E., Eckert Dominique, Eguchi Satoshi, Enoto Teruaki, Ezoe Yuichiro, Foster Adam, Fujimoto Ryuichi, Fujita Yutaka, Fukazawa Yasushi, Fukushima Kotaro, Furuzawa Akihiro, Gallo Luigi, García Javier A., Gu Liyi, Guainazzi Matteo, Hagino Kouichi, Hamaguchi Kenji, Hatsukade Isamu, Hayashi Katsuhiro, Hayashi Takayuki, Hell Natalie, Hodges-Kluck Edmund, Hornschemeier Ann, Ichinohe Yuto, Ishi Daiki, Ishida Manabu, Ishikawa Kumi, Ishisaki Yoshitaka, Kaastra Jelle, Kallman Timothy, Kara Erin, Katsuda Satoru, Kanemaru Yoshiaki, Kelley Richard, Kilbourne Caroline, Kitamoto Shunji, Kobayashi Shogo, Kohmura Takayoshi, Kubota Aya, Leutenegger Maurice, Loewenstein Michael, Maeda Yoshitomo, Markevitch Maxim, Matsumoto Hironori, Matsushita Kyoko, McCammon Dan, McNamara Brian, Mernier François, Miller Eric D., Miller Jon M., Mitsuishi Ikuyuki, Mizumoto Misaki, Mizuno Tsunefumi, Mori Koji, Mukai Koji, Murakami Hiroshi, Mushotzky Richard, Nakajima Hiroshi, Nakazawa Kazuhiro, Ness Jan-Uwe, Nobukawa Kumiko, Nobukawa Masayoshi, Noda Hirofumi, Odaka Hirokazu, Ogawa Shoji, Ogorzałek Anna, Okajima Takashi, Ota Naomi, Paltani Stephane, Petre Robert, Plucinsky Paul, Porter Frederick S., Pottschmidt Katja, Sato Kosuke, Sato Toshiki, Sawada Makoto, Seta Hiromi, Shidatsu Megumi, Simionescu Aurora, Smith Randall, Suzuki Hiromasa, Szymkowiak Andrew, Takahashi Hiromitsu, Takeo Mai, Tamagawa Toru, Tamura Keisuke, Tanaka Takaaki, Tanimoto Atsushi, Tashiro Makoto, Terada Yukikatsu, Terashima Yuichi, Tsuboi Yohko, Tsujimoto Masahiro, Tsunemi Hiroshi, Tsuru Takeshi, Tümer Ayşegül, Uchida Hiroyuki, Uchida Nagomi, Uchida Yuusuke, Uchiyama Hideki, Ueda Shutaro, Ueda Yoshihiro, Uno Shinichiro, Vink Jacco, Watanabe Shin, Williams Brian J., Yamada Satoshi, Yamada Shinya, Yamaguchi Hiroya, Yamaoka Kazutaka, Yamasaki Noriko, Yamauchi Makoto, Yamauchi Shigeo, Yaqoob Tahir, Yoneyama Tomokage, Yoshida Tessei, Yukita Mihoko, Zhuravleva Irina, Bellomi Elena, Drury Ian, Heinrich Annie, Hlavacek-Larrondo Julie, Meunier Julian, Migkas Konstantinos, Shefler Lior, Stancil Phillip C., Truong Nhut, Vigneron Benjamin, Zhang Congyao, ZuHone John   +144 more
doaj   +1 more source