Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
Molecular Oncology, EarlyView.The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim +17 more
wiley +1 more source
Manufacture of Industrial Scale Bagasse Biochar: Effect of Temperature And Residence Time And Biochar Characterization [PDF]
. Bagasse is a waste that can still be utilized, one of which is processed into biochar. In this study, bagasse waste came from a sugar factory in Majalengka, Cirebon, West Java.
Hakika, Dhias Cahya +2 more
core +1 more source
FEBS Open Bio, EarlyView.Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei +3 more
wiley +1 more source
A light-fuelled nanoratchet shifts a coupled chemical equilibrium. [PDF]
Nat Nanotechnol, 2022 Kathan M +11 more
europepmc +1 more source
Impact parameter dependencies in Pb(160 AGeV)+Pb reactions : hydrodynamical vs. cascade calculations [PDF]
, 2005 We investigate the impact parameter dependence of the specific entropy S/A in relativistic heavy ion collisions. Especially the anti-Lambda/anti-proton ratio is found to be a useful tool to distinguish between chemical equilibrium assumptions assumed in ...
Greiner, Walter +6 more
core
Utilization of Tofu Liquid Waste as Liquid Organic Fertilizer Using the Fermentation Method with Activator Effective Microorganisms 4 (EM-4): A Review [PDF]
Liquid organic fertilizer is organic fertilizer in liquid form which is partly or wholly derived from organic compounds such as plant, animal and industrial residues, in solid or liquid form.
Maryudi, Maryudi +2 more
core +1 more source
Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies
FEBS Open Bio, EarlyView.We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli +8 more
wiley +1 more source
Author Correction: A light-fuelled nanoratchet shifts a coupled chemical equilibrium. [PDF]
Nat Nanotechnol, 2022 Kathan M +11 more
europepmc +1 more source
Some considerations on the fundamentals of chemical kinetics: steady state, quasi-equilibrium, and transition state theory [PDF]
, 2019 The elementary reaction sequence A ↔ I → P is the simplest mechanism for which the steady-state and quasi-equilibrium kinetic approximations can be applied.
Pérez de Benito, Joaquín F.
core +1 more source