Results 81 to 90 of about 1,123,379 (326)
Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid +3 more
wiley +1 more source
Determination of the Equilibrium Parameters of Gaseous Detonations Using a Genetic Algorithm [PDF]
The present work is concerned with the development of a new algorithm for determination of the equilibrium composition of gaseous detonations. The elements balance equations, and the second law of thermodynamics (i.e., the minimization of the Gibbs free ...
doaj
Dynamical screening away from equilibrium: hard photon production and collisional energy loss [PDF]
We investigate the production rate for hard real photons and the collisional energy loss in the quark-gluon plasma away from chemical equilibrium. Applying the Hard-Thermal-Loop resummation scheme away from equilibrium, we can show that Landau damping ...
Baier, R., Dirks, M., Redlich, K.
core +1 more source
We investigated the toxicity of 12 active compounds commonly found in herbal weight loss supplements (WLS) using human liver and colon cell models. Epigallocatechin‐3‐gallate was the only compound showing significant toxicity. Metabolic profiling revealed protein degradation, disrupted energy and lipid metabolism suggesting that the inclusion of EGCG ...
Emily C. Davies +3 more
wiley +1 more source
Computer program for calculation of complex chemical equilibrium compositions [PDF]
Computer program is described for numerical solution of chemical equilibria in complex systems by using nonlinear algebraic equations.
Gordon, S., Mcbride, B. J.
core +1 more source
Fermi edge singularity in a non-equilibrium system
We report exact results for the Fermi Edge Singularity in the absorption spectrum of an out-of-equilibrium tunnel junction. We consider two metals with chemical potential difference V separated by a tunneling barrier containing a defect, which exists in ...
B. Braunecker +6 more
core +1 more source
dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon +6 more
wiley +1 more source
The equilibrium density distribution and thermodynamic properties of a Lennard-Jones fluid confined to nano-sized spherical cavities at constant chemical potential was determined using Monte Carlo simulations.
Alejandre J +9 more
core +1 more source
Enzymatic degradation of biopolymers in amorphous and molten states: mechanisms and applications
This review explains how polymer morphology and thermal state shape enzymatic degradation pathways, comparing amorphous and molten biopolymer structures. By integrating structure–reactivity principles with insights from thermodynamics and enzyme engineering, it highlights mechanisms that enable efficient polymer breakdown.
Anđela Pustak, Aleksandra Maršavelski
wiley +1 more source
Mouse pre‐implantation development involves a transition from totipotency to pluripotency. Integrating transcriptomics, epigenetic profiling, low‐input proteomics and functional assays, we show that eight‐cell embryos retain residual totipotency features, whereas cytoskeletal remodeling regulated by the ubiquitin‐proteasome system drives progression ...
Wanqiong Li +8 more
wiley +1 more source

