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Autocatalytic Sets Arising in a Combinatorial Model of Chemical Evolution [PDF]

open access: yesLife, 2022
The idea that chemical evolution led to the origin of life is not new, but still leaves open the question of how exactly it could have led to a coherent and self-reproducing collective of molecules.
Wim Hordijk, Mike Steel, Stuart Kauffman
doaj   +4 more sources

The Informational Substrate of Chemical Evolution: Implications for Abiogenesis [PDF]

open access: yesLife, 2019
A key aspect of biological evolution is the capacity of living systems to process information, coded in deoxyribonucleic acid (DNA), and used to direct how the cell works.
Andrés de la Escosura
doaj   +2 more sources

Chemical Evolution of a Bacterium’s Genome [PDF]

open access: yesAngewandte Chemie - International Edition, 2011
We set out to develop a generic technology for evolving the chemical constitution of microbial populations by using the simplest possible algorithm. Extant living cells polymerize a restricted set of nucleic acid precursors, namely, four nucleoside triphosphates (UTP, CTP, ATP, GTP) and four deoxynucleoside triphosphates (dTTP, dCTP, dATP, dGTP ...
Volker Döring   +2 more
exaly   +5 more sources

A recursive microfluidic platform to explore the emergence of chemical evolution [PDF]

open access: yesBeilstein Journal of Organic Chemistry, 2017
We propose that a chemically agnostic approach to explore the origin of life, using an automated recursive platform based on droplet microfluidics, could be used to induce artificial chemical evolution by iterations of growth, speciation, selection, and ...
David Doran   +4 more
doaj   +2 more sources

Retrocausality in Quantum Phenomena and Chemical Evolution

open access: yesInformation, 2016
The interplay between retrocausality and the time-reversal symmetry of the dynamical law of quantum mechanics underscores the significance of the measurement dynamics with the use of indivisible and discrete quantum particles to be mediated.
Koichiro Matsuno
doaj   +3 more sources

Primitive Photosynthetic Architectures Based on Self‐Organization and Chemical Evolution of Amino Acids and Metal Ions [PDF]

open access: yesAdvanced Science, 2018
The emergence of light‐energy‐utilizing metabolism is likely to be a critical milestone in prebiotic chemistry and the origin of life. However, how the primitive pigment is spontaneously generated still remains unknown.
Kai Liu   +4 more
doaj   +2 more sources

Chemical Evolution of Antivirals Against Enterovirus D68 through Protein-Templated Knoevenagel Reactions. [PDF]

open access: yesAngew Chem Int Ed Engl, 2021
Tauber C   +10 more
europepmc   +2 more sources

Differential Oligomerization of Alpha versus Beta Amino Acids and Hydroxy Acids in Abiotic Proto-Peptide Synthesis Reactions

open access: yesLife, 2022
The origin of biopolymers is a central question in origins of life research. In extant life, proteins are coded linear polymers made of a fixed set of twenty alpha-L-amino acids.
Moran Frenkel-Pinter   +6 more
doaj   +1 more source

Thioesters provide a plausible prebiotic path to proto-peptides

open access: yesNature Communications, 2022
One of the early processes enabling the origins of life is thought to be the condensation of building blocks into oligomers and polymers. In this article, the authors report the synthesis of thiodepsipeptides and HS-peptides under mild temperatures and ...
Moran Frenkel-Pinter   +6 more
doaj   +1 more source

Mutually stabilizing interactions between proto-peptides and RNA

open access: yesNature Communications, 2020
Cooperative relationships are widespread among different classes of biopolymers and are predicted to have existed during emergence of life. This study shows that proto-peptides engage in mutually stabilizing interactions with RNA, providing support for ...
Moran Frenkel-Pinter   +9 more
doaj   +1 more source

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