Chemical evolution of primordial salts and organic sulfur molecules in the asteroid 162173 Ryugu. [PDF]
Nat Commun, 2023 Samples from the carbonaceous asteroid (162173) Ryugu provide information on the chemical evolution of organic molecules in the early solar system. Here we show the element partitioning of the major component ions by sequential extractions of salts ...
Yoshimura T +43 more
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Chemical evolution of an autonomous DNAzyme with allele-specific gene silencing activity. [PDF]
Nat Commun, 2023 Low activity has been the primary obstacle impeding the use of DNA enzymes (DNAzymes) as gene silencing agents in clinical applications. Here we describe the chemical evolution of a DNAzyme with strong catalytic activity under near physiological ...
Nguyen K, Malik TN, Chaput JC.
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Chemical Evolution of Natural Product Structure. [PDF]
J Am Chem Soc, 2022 Natural products are the result of Nature’s exploration of biologically relevant chemical space through evolution and an invaluable source of bioactive small molecules for chemical biology and medicinal chemistry.
Grigalunas M, Brakmann S, Waldmann H.
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Pseudo Natural Products-Chemical Evolution of Natural Product Structure. [PDF]
Angew Chem Int Ed Engl, 2021 Pseudo‐natural products (PNPs) combine natural product (NP) fragments in novel arrangements not accessible by current biosynthesis pathways. As such they can be regarded as non‐biogenic fusions of NP‐derived fragments.
Karageorgis G +4 more
europepmc +2 more sources
Autocatalytic Sets Arising in a Combinatorial Model of Chemical Evolution [PDF]
Life, 2022 The idea that chemical evolution led to the origin of life is not new, but still leaves open the question of how exactly it could have led to a coherent and self-reproducing collective of molecules.
Wim Hordijk, Mike Steel, Stuart Kauffman
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The chemical evolution of oligonucleotide therapies of clinical utility. [PDF]
Nat Biotechnol, 2017 After nearly 40 years of development, oligonucleotide therapeutics are nearing meaningful clinical productivity. One of the key advantages of oligonucleotide drugs is that their delivery and potency are derived primarily from the chemical structure of ...
Khvorova A, Watts JK.
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Role of Mineral Surfaces in Prebiotic Chemical Evolution. In Silico Quantum Mechanical Studies. [PDF]
Life (Basel), 2019 There is a consensus that the interaction of organic molecules with the surfaces of naturally-occurring minerals might have played a crucial role in chemical evolution and complexification in a prebiotic era.
Rimola A, Sodupe M, Ugliengo P.
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Chemical evolution of atmospheric organic carbon over multiple generations of oxidation. [PDF]
Nat Chem, 2018 The evolution of atmospheric organic carbon as it undergoes oxidation has a controlling influence on concentrations of key atmospheric species, including particulate matter, ozone and oxidants.
Isaacman-VanWertz G +20 more
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Primitive Photosynthetic Architectures Based on Self‐Organization and Chemical Evolution of Amino Acids and Metal Ions [PDF]
Advanced Science, 2018 The emergence of light‐energy‐utilizing metabolism is likely to be a critical milestone in prebiotic chemistry and the origin of life. However, how the primitive pigment is spontaneously generated still remains unknown.
Kai Liu +4 more
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The Informational Substrate of Chemical Evolution: Implications for Abiogenesis [PDF]
Life, 2019 A key aspect of biological evolution is the capacity of living systems to process information, coded in deoxyribonucleic acid (DNA), and used to direct how the cell works.
Andrés de la Escosura
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