Chemical evolution of an autonomous DNAzyme with allele-specific gene silencing activity. [PDF]
Nat Commun, 2023 Low activity has been the primary obstacle impeding the use of DNA enzymes (DNAzymes) as gene silencing agents in clinical applications. Here we describe the chemical evolution of a DNAzyme with strong catalytic activity under near physiological ...
Nguyen K, Malik TN, Chaput JC.
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Chemical Evolution of Natural Product Structure. [PDF]
J Am Chem Soc, 2022 Natural products are the result of Nature’s exploration of biologically relevant chemical space through evolution and an invaluable source of bioactive small molecules for chemical biology and medicinal chemistry.
Grigalunas M, Brakmann S, Waldmann H.
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Pseudo Natural Products-Chemical Evolution of Natural Product Structure. [PDF]
Angew Chem Int Ed Engl, 2021 Pseudo‐natural products (PNPs) combine natural product (NP) fragments in novel arrangements not accessible by current biosynthesis pathways. As such they can be regarded as non‐biogenic fusions of NP‐derived fragments.
Karageorgis G +4 more
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Autocatalytic Sets Arising in a Combinatorial Model of Chemical Evolution [PDF]
Life, 2022 The idea that chemical evolution led to the origin of life is not new, but still leaves open the question of how exactly it could have led to a coherent and self-reproducing collective of molecules.
Wim Hordijk, Mike Steel, Stuart Kauffman
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Natural Radioactivity and Chemical Evolution on the Early Earth: Prebiotic Chemistry and Oxygenation [PDF]
Molecules, 2022 It is generally recognized that the evolution of the early Earth was affected by an external energy source: radiation from the early Sun. The hypothesis about the important role of natural radioactivity, as a source of internal energy in the evolution of
Boris Ershov
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The Informational Substrate of Chemical Evolution: Implications for Abiogenesis [PDF]
Life, 2019 A key aspect of biological evolution is the capacity of living systems to process information, coded in deoxyribonucleic acid (DNA), and used to direct how the cell works.
Andrés de la Escosura
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Role of Mineral Surfaces in Prebiotic Chemical Evolution. In Silico Quantum Mechanical Studies. [PDF]
Life (Basel), 2019 There is a consensus that the interaction of organic molecules with the surfaces of naturally-occurring minerals might have played a crucial role in chemical evolution and complexification in a prebiotic era.
Rimola A, Sodupe M, Ugliengo P.
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A recursive microfluidic platform to explore the emergence of chemical evolution [PDF]
Beilstein Journal of Organic Chemistry, 2017 We propose that a chemically agnostic approach to explore the origin of life, using an automated recursive platform based on droplet microfluidics, could be used to induce artificial chemical evolution by iterations of growth, speciation, selection, and ...
David Doran +4 more
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Primitive Photosynthetic Architectures Based on Self‐Organization and Chemical Evolution of Amino Acids and Metal Ions [PDF]
Advanced Science, 2018 The emergence of light‐energy‐utilizing metabolism is likely to be a critical milestone in prebiotic chemistry and the origin of life. However, how the primitive pigment is spontaneously generated still remains unknown.
Kai Liu +4 more
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Retrocausality in Quantum Phenomena and Chemical Evolution
Information, 2016 The interplay between retrocausality and the time-reversal symmetry of the dynamical law of quantum mechanics underscores the significance of the measurement dynamics with the use of indivisible and discrete quantum particles to be mediated.
Koichiro Matsuno
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