Results 131 to 140 of about 6,179,886 (326)
Chemical nitrogen fractionation in dense molecular clouds
Monthly Notices of the Royal Astronomical Society, 2018 21 pages, 3 ...
Loison, Jean-Christophe +3 more
openaire +3 more sources
Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA
Molecular Oncology, EarlyView.Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson +2 more
wiley +1 more source
Correction: Salazar-Cubillas, K.C.; Dickhoefer, U. Evaluating the Protein Value of Fresh Tropical Forage Grasses and Forage Legumes Using In Vitro and Chemical Fractionation Methods. Animals 2021, 11, 2853. [PDF]
Animals (Basel), 2022 Salazar-Cubillas KC, Dickhoefer U.
europepmc +1 more source
CH2D+, the Search for the Holy Grail
, 2013 CH2D+, the singly deuterated counterpart of CH3+, offers an alternative way to mediate formation of deuterated species at temperatures of several tens of K, as compared to the release of deuterated species from grains.
cernicharo, J. +6 more
core +2 more sources
Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting
Molecular Oncology, EarlyView.CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia +9 more
wiley +1 more source
BioResources, 2010 The current state of biorefinery development is focused almost entirely on the production of fuel ethanol. However, an ethanol-centric approach misses the crucial example set by the petrochemical industry.
Joseph J. Bozell
doaj
Molecular Oncology, EarlyView.Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz +15 more
wiley +1 more source
Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway
Molecular Oncology, EarlyView.Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed +10 more
wiley +1 more source
New solar metallicity measurements
, 2019 In the past years, a systematic downward revision of the metallicity of the Sun has led to the "solar modeling problem", namely the disagreement between predictions of standard solar models and inferences from helioseismology.
Vagnozzi, Sunny
core +1 more source
Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source