Chemical leukoderma induced by dimethyl sulfate [PDF]
Anais Brasileiros de Dermatologia, 2016 Chemical leukoderma occurs due to the toxic effect of a variety of chemical agents. Mechanisms include either destruction or inhibition of melanocytes.
Maya Valeska Gozali +4 more
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Pathogenesis of Chemical Leukoderma and Chemical-Induced Vitiligo. [PDF]
J DermatolABSTRACT Leukoderma/vitiligo is a serious pigmentary disorder that notably impairs the patient's quality of life. In particular, chemical leukoderma (CL)/vitiligo refers to acquired depigmentation of the skin induced by exposure to certain chemicals.
Kuroda Y, Yang L, Katayama I.
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Chemical Leukoderma: A Rare Adverse Effect of the Rotigotine Patch. [PDF]
Mov Disord Clin Pract, 2017 Rotigotine, marketed as Neupro, is a non-ergot dopamine agonist (DA) available as a transdermal therapeutic system (TTS).1 It was approved in 2007 for Parkinson's disease (PD)2 and in 2008 for Restless Leg Syndrome.3 It has high affinity for the D3/D2/D1 receptors.1 The TTS gives Rotigotine the advantage of direct entry into the systemic circulation ...
Prakash N, Chand P.
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In Vitro Methods for Predicting Chemical Leukoderma Caused by Quasi-Drug Cosmetics [PDF]
Cosmetics, 2017 Skin care cosmetics frequently contain whitening or lightening agents. The present study aimed to establish in vitro methods for predicting chemical leukoderma caused by whitening agents in cosmetics. The risks of chemical leukoderma were predicted based
Lihao Gu +3 more
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Chemical leukoderma after the application of a transdermal methylphenidate patch. [PDF]
J Am Acad Dermatol, 2012 Ghasri P, Gattu S, Saedi N, Ganesan AK.
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Leukoderma Induced by Rotigotine Patch, a Transdermal Dopamine Agonist [PDF]
Case Reports in Dermatology, 2022 Leukoderma, or hypomelanosis of the skin, can occur in response to various chemical and pharmacologic substances ranging from topical medications to optic preparations and systemic medications.
Ronan Talty +4 more
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Metabolism of Enantiomers of Rhododendrol in Human Skin Homogenate [PDF]
Metabolites, 2022 We reported that raspberry ketone (RK) is produced from rhododendrol (RD) in excised mouse skin. We confirmed that RK is also produced from RD in human skin homogenates.
Lihao Gu, Kazuhisa Maeda
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Chemical- and Drug-Induced Allergic, Inflammatory, and Autoimmune Diseases Via Haptenation [PDF]
Biology, 2023 Haptens are small molecules that only elicit an immune response when bound to proteins. Haptens initially bind to self-proteins and activate innate immune responses by complex mechanisms via inflammatory cytokines and damage-associated molecular patterns
Eri Sakamoto +14 more
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Thymol-Induced Chemical Leukoderma Successfully Treated with 308-Nanometer Excimer Laser. [PDF]
Skin Appendage Disord, 2020 <b><i>Introduction:</i></b> Chemical leukoderma (CL) is an acquired depigmenting disorder caused by repeated exposure to chemical compounds. Thymol is a phenol derivative used as a preservative or antiseptic in many commercially available products.
Weigelt MA +3 more
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A Cell-Based Evaluation of the Tyrosinase-Mediated Metabolic Activation of Leukoderma-Inducing Phenols, II: The Depletion of Nrf2 Augments the Cytotoxic Effect Evoked by Tyrosinase in Melanogenic Cells [PDF]
BiomoleculesChemical leukoderma is a disorder induced by chemicals such as rhododendrol and monobenzone. These compounds possess a p-substituted phenol moiety and undergo oxidation into highly reactive and toxic o-quinone metabolites by tyrosinase.
Tomoko Nishimaki-Mogami +5 more
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