Results 81 to 90 of about 5,494,217 (358)

Comparative Study of Predicting the Molecular Diffusion Coefficient for Polar and Non-polar Binary Gas Using Neural Networks and Multiple Linear Regressions [PDF]

Kemija u Industriji, 2019
In the current study, an artificial neural network (ANN) and multiple linear regressions (MLR) have been used to develop predictive models for the estimation of molecular diffusion coefficients of 1252 polar and non-polar binary gases at multiple ...
Naima Melzi, Latifa Khaouane, Yamina Ammi, Salah Hanini, Maamar Laidi, Hamid Zentou   +5 more
doaj   +1 more source

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source

A Stochastic Multi-scale Approach for Numerical Modeling of Complex Materials - Application to Uniaxial Cyclic Response of Concrete

, 2016
In complex materials, numerous intertwined phenomena underlie the overall response at macroscale. These phenomena can pertain to different engineering fields (mechanical , chemical, electrical), occur at different scales, can appear as uncertain, and are
Adnan Ibrahimbegovic, Adnan Ibrahimbegović, Ana Paula Moreno Trigo, André Zaoui, C. Miehe, D.C. Charmpis, Damijan Markovic, Dimitris Savvas, F. Ragueneau, Frédéric Feyel, George Deodatis, George Deodatis, J. Lubliner, M Gioffrè, M.D. Shields, Martin Ostoja-Starzewski, Masanobu Shinozuka, P. Germain, P. Ladevèze, Paolo Bocchini, Pierre Jehel, Pierre Jehel, R. Cottereau, R. Popescu, Sia Nemat-Nasser, Vissarion Papadopoulos   +25 more
core   +3 more sources

Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA

Molecular Oncology, EarlyView.
Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson, Anders Lade Nielsen, Boe Sandahl Sorensen   +2 more
wiley   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

How do chemical properties of the atoms change under pressure

, 2015
Abundant evidence has shown the emergence of dramatic new chemical phenomena under pressure, including the formation of unexpected crystal structures and completely new counterintuitive compounds.
Dong, Xiao, Oganov, Artem R., Qian, Guangrui, Wang, Hui-Tian, Zhou, Xiang-Feng, Zhu, Qiang   +5 more
core  

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Charge redistribution from anomalous magnetovorticity coupling

, 2016
We investigate novel transport phenomena in a chiral fluid originated from an interplay between a vorticity and strong magnetic field, which induces a redistribution of vector charges in the system and an axial current along the magnetic field.
Hattori, Koichi, Yin, Yi
core   +1 more source

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

Numerical modeling tools for chemical vapor deposition [PDF]

Development of general numerical simulation tools for chemical vapor deposition (CVD) was the objective of this study. Physical models of important CVD phenomena were developed and implemented into the commercial computational fluid dynamics software ...
Childs, Edward P., Jasinski, Thomas J.
core   +1 more source