Results 101 to 110 of about 4,081,913 (299)

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

Effect of $U_A(1)$ Breaking on Chiral Phase Structure and Pion Superfluidity at Finite Isospin Chemical Potential

, 2006
We investigate the isospin chemical potential effect in the frame of SU(2) Nambu-Jona-Lasinio model. When the isospin chemical potential is less than the vacuum pion mass, the phase structure with two chiral phase transition lines does not happen due to $
He, Lianyi, Jin, Meng, Zhuang, Pengfei
core   +2 more sources

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Imaginary chemical potential in QCD at finite temperature

, 2002
After presenting a brief review of how simulations of QCD with imaginary chemical potential can be used to extract physical results, we analyse the phase structure of QCD with four flavours of dynamical fermions in the finite temperature - imaginary ...
D'Elia, M., Lombardo, M. P.
core   +1 more source

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

Study on separation, purification and chemical structure of Curdlan polysaccharide

浙江大学学报. 农业与生命科学版, 2004
Curdlan polysaccharide was isolated from the fermentation broth of Alcaligenes faecelis var. C125 by acid and alkali and the rude sample CD-1 was gained. The protein and pigment were removed from CD-I by Sevage method and cellulose column chromatography,
LI Zhi-ang, LI Wei-qi, YAN Ban-gan, He Guo-qing   +3 more
doaj   +1 more source

LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro

Molecular Oncology, EarlyView.
Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix, Daniel Samaga, Katharina Gehr, Benedek Dankó, Mohamed Schumann, Guido Drexler, Ahmed Alnatsha, Georg Beyer, Ujjwal Mahajan, Martin Selmansberger, Julia Mayerle, Claus Belka, Horst Zitzelsberger, Kirsten Lauber   +13 more
wiley   +1 more source

Colonization of biological soil crusts and herbaceous plants in new citrus orchards altered imidacloprid sorption-desorption behaviour in soils

Environmental Research Communications
Neonicotinoids are a class of insecticides commonly employed in citrus orchards to combat the disease huanglongbing, making these orchards a significant source of neonicotinoid pollution.
Y H Niu, X Li, J Lv, Z Y Hao, L Wang, Z H Shi   +5 more
doaj   +1 more source

Solution Structures of \u3cem\u3eMycobacterium tuberculosis\u3c/em\u3e Thioredoxin C and Models of Intact Thioredoxin System Suggest New Approaches to Inhibitor and Drug Design [PDF]

, 2013
Here, we report the NMR solution structures of Mycobacterium tuberculosis (M. tuberculosis) thioredoxin C in both oxidized and reduced states, with discussion of structural changes that occur in going between redox states.
Cai, Sheng, Neumann, Terrence S., Olson, Andrew Lawrence, Sem, Daniel S.   +3 more
core   +1 more source

On Chemical Structure [PDF]

Proceedings of the Royal Society of Edinburgh
In this paper the author drew attention to the nature of the process of Chemical Exchange (including substitution, double decomposition, and some cases of direct addition and subtraction), as a process by which the number of relations in which any given atom stands is unaffected.
openaire   +1 more source