Results 81 to 90 of about 1,475,907 (268)
Research on the Mechanism of Fault Activation and Water Inrush Across Variable Coal Pillar Widths
Advances in Civil EngineeringDuring coal mining operations, the activation of geological faults induced by mining activities, leading to sudden water inrush, presents a significant technical challenge to safe extraction.
Hongjin Sun +3 more
doaj +1 more source
THE CHEMICAL STRUCTURE OF THE BODY [PDF]
Quarterly Journal of Experimental Physiology and Cognate Medical Sciences, 1956 R A, McCANCE, E M, WIDDOWSON
openaire +2 more sources
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
Collective total synthesis of stereoisomeric yohimbine alkaloids
Nature CommunicationsStereoisomeric polycyclic natural products are important for drug discovery-based screening campaigns, due to the close correlation of stereochemistry with diversified bioactivities.
Meiyi Tang, Haigen Lu, Liansuo Zu
doaj +1 more source
Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions
FEBS Letters, EarlyView.The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang +4 more
wiley +1 more source
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
FEBS Letters, EarlyView.Although too much iron in the brain promotes neurodegeneration, iron ion chelators have had mixed effects in clinical trials. This review explains why; some chelators do not render the iron redox‐inactive (e.g., L1) whereas others do (e.g., desferrioxamine).
Barry Halliwell
wiley +1 more source
SmartMatEven though existing near‐infrared probes have successfully achieved deep tissue imaging with high contrast, it remains challenging to image many species simultaneously under complicated biological conditions. We rationally design and synthesize a series
Zetao Dang +9 more
doaj +1 more source
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
The Blood-Brain Barrier in Both Humans and Rats: A Perspective From 3D Imaging
International Journal of Biomedical ImagingConclusions: The present study demonstrated the 3D structure of both the human and rat BBB, which is discrepant from the 2D one. Tissue clearing and 3D imaging are promising techniques to answer more questions about the real structure of biological ...
Aiwen Chen +7 more
doaj +1 more source