Results 81 to 90 of about 4,081,913 (299)

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Model atmospheres of chemically peculiar stars: Self-consistent empirical stratified model of HD24712

, 2009
High-resolution spectra of some chemically peculiar stars clearly demonstrate the presence of strong abundance gradients in their atmospheres. However, these inhomogeneities are usually ignored in the standard scheme of model atmosphere calculations ...
Alecian, Babel, Bard, Bard, Black, Blackwell, Blackwell, Blanco, Campos, D. Shulyak, Fleurier, Garz, Goncharsky, Hauck, Hauschildt, Hui-Bon-Hoa, Khan, Khan, Kochukhov, Kochukhov, Kochukhov, Kochukhov, Kochukhov, Kupka, L. Mashonkina, Lueftinger, Lundberg, Mashonkina, Mashonkina, Mashonkina, Mashonkina, Michaud, Nieuwenhuijzen, O. Kochukhov, Piskunov, Piskunov, Piskunov, Raassen, Ryabchikova, Ryabchikova, Ryabchikova, Ryabchikova, Rybicki, Rybicki, Seaton, Smith, Smith, Smith, Smith, Stepanov, T. Ryabchikova, Vogt, Warner, Weiss, Wolff   +54 more
core   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Deep Eutectic Solvent Pretreatment and Green Separation of Lignocellulose

Applied Sciences
Plant-based waste biomass with lignocellulose as an important component is produced in large quantities worldwide every year. The components of lignocellulose that typically exhibit high utilization value include cellulose and hemicellulose, as well as ...
Zhengyuan Yao, Gunhean Chong, Haixin Guo
doaj   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Research progress of Gastrodia elata Blume polysaccharides: a review of chemical structures and biological activities

Frontiers in Chemistry
Gastrodia elata Blume (G. elata), listed as one of the 34 precious Chinese medicines, servers a dual purpose as both a medicinal herb and a food source. Polysaccharide is the main active ingredient in G.
Liu Yang, Liu Yang, Shi-Hui Qin, Cheng-Ting Zi, Cheng-Ting Zi   +4 more
doaj   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Structural Characterization of Polysaccharides from Noni (Morinda citrifolia L.) Juice and Their Preventive Effect on Oxidative Stress Activity

Molecules
Polysaccharides are very promising molecules in the field of pharmacotherapy. Knowing this, the aim of this study was to extract, characterize, and evaluate the action of the polysaccharides in noni juice, using biological models of Type 2 diabetes ...
Bin Zhang, Xiaoyu Wei, Peiwen Du, Huangqun Luo, Lanfang Hu, Liping Guan, Guangying Chen   +6 more
doaj   +1 more source

Thin-film chemical sensors based on electron tunneling [PDF]

The physical mechanisms underlying a novel chemical sensor based on electron tunneling in metal-insulator-metal (MIM) tunnel junctions were studied. Chemical sensors based on electron tunneling were shown to be sensitive to a variety of substances that ...
Khanna, S. K., Lambe, J., Leduc, H. G., Thakoor, A. P.   +3 more
core   +1 more source

The predicted crystal structure of Li_4C_6O_6, an organic cathode material for Li-ion batteries, from first-principles multi-level computational methods [PDF]

, 2011
In this communication, we use first-principles based multi-level computational methods to predict the crystal structure of Li_4C_6O_6, the key intermediate material that can be oxidized to Li_2C_6O_6 or reduced to Li_6C_6O_6.
Goddard, William A. III, Kang, Kisuk, Kim, Haegyeom, Kim, Hyungjun, Seo, Dong-Hwa   +4 more
core