Results 31 to 40 of about 531 (218)

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Results from the first spectropolarimetric survey of γ Dor pulsators

Astronomy & Astrophysics
Context. Magnetic fields can have an important influence on stellar structure and evolution. In intermediate-mass (A- and F-type) stars, there are many known stars with directly measured strong, globally organized magnetic fields, as well as indications ...
Labadie-Bartz J., Ouazzani R., Neiner C., Antoci V., Stanley P., Natan T., Thomson-Paressant K., Chojnowski S. D., Mas Sanz B., Dürfeldt Pedros O., Petit V.   +10 more
doaj   +1 more source

Structural and biochemical analysis of a B12 superbinder

FEBS Letters, EarlyView.
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices, Jacob J. Whittaker, Dirk J. Slotboom, Albert Guskov   +3 more
wiley   +1 more source

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

FEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

ON THE POSSIBLE NATURE OF Bp-Ap STARS: AN APPLICATION TO HD101065 and HR465

Odessa Astronomical Publications, 2007
We have proposed the new explanation of some magnetic chemically peculiar (MCP) stars anomalies, which is based on assumption that such stars can be the close binary systems with a secondary component being neutron star.
V. F. Gopka, O. M. Ulyanov, S. M. Andrievsky   +2 more
doaj   +1 more source

Spectroscopic Study of Ba and CEMP-s Stars: Mass Distribution of AGB Progenitors

The Astronomical Journal, 2023
We have performed detailed high-resolution spectroscopic analysis on seven metal-poor stars (BD+75 348, BD+09 3019, HD238020, HE0319–0215, HE0507–1653, HE0930–0018, HE1023–1504) and derived their atmospheric parameters T _eff , log g , [Fe/H], and ...
Partha Pratim Goswami, Aruna Goswami
doaj   +1 more source

Chiral separation of chloroalkanes with the chromatographic column onboard Martian rovers

FEBS Letters, EarlyView.
Computer image of the Rosalind Franklin Rover of ESA's ExoMars mission. ExoMars is scheduled to land on planet Mars in Oxia Planum in 2029. This area represents an interesting spot to look for biosignatures. Investigations of ExoMars include measurement on molecular chirality. We show that chiral chloroalkanes, that have been identified on Mars, can be
Asma Merzougui, Agnes Banreti, Armelle L. Ernst, Guillaume Leseigneur, Uwe J. Meierhenrich   +4 more
wiley   +1 more source

Cool, Luminous, and Highly Variable Stars in the Magellanic Clouds. II. Spectroscopic and Environmental Analysis of Thorne–Żytkow Object and Super-AGB Star Candidates

The Astrophysical Journal, 2023
In previous work, we identified a population of 38 cool and luminous variable stars in the Magellanic Clouds and examined 11 in detail in order to classify them as either Thorne–Żytkow objects (TŻOs; red supergiants with a neutron star cores) or super ...
Anna J. G. O‘Grady, Maria R. Drout, B. M. Gaensler, C. S. Kochanek, Kathryn F. Neugent, Carolyn L. Doherty, Joshua S. Speagle, B. J. Shappee, Michael Rauch, Ylva Götberg, Bethany Ludwig, Todd A. Thompson   +11 more
doaj   +1 more source

L‐aspartate oxidase provides new insights into fumarate reduction in anaerobic darkness in Synechocystis sp. PCC6803

FEBS Letters, EarlyView.
Synechocystis strains deficient in succinate dehydrogenase (SDH) secrete more succinate than the WT under dark anaerobic conditions, supporting that SDH then primarily acts as SDH, not as a fumarate reductase. L‐aspartate oxidase (Laspo) from Synechocystis is functional under anaerobic conditions, reducing fumarate to succinate.
Kateryna Kukil, Jeffrey A. Hawkes, Cecilia Blikstad, Pia Lindberg   +3 more
wiley   +1 more source