Results 51 to 60 of about 531 (218)

Wildly oscillating stars

Astronomy & Astrophysics
Aims. We investigate the origin of the dense, ridge-like frequency clusters observed in a subset of A- and F-type pulsating stars, which we refer to as ‘wildly oscillating’ stars (WOSs).
Antoci V., Labadie-Bartz J., Święch M., Dürfeldt-Pedros O., Murphy S. J., Kurtz D. W., Bedding T. R., Handler G., Fuller J., Ouazzani R.-M., Kjeldsen H., Fellay L., Gade Pedersen M., Niemczura E., Bowman D. M., Deal M., Mani P.   +16 more
doaj   +1 more source

DNA ligase LigE increases bacterial transformation with damaged extracellular DNA

FEBS Letters, EarlyView.
The DNA ligase LigE from the naturally competent Gram‐negative bacterium Neisseria gonorrhoaea increases transformation with cut extracellular DNA. This process is ATP‐dependent and relies on the catalytic activity of LigE; it also requires that LigE contains an intact periplasmic localisation sequence, indicating that ligE functions in the periplasm ...
Jolyn Pan, Avi Singh, Shrawani Weralupe Gamladdalage, Joanna Hicks, Adele Williamson   +4 more
wiley   +1 more source

Unlocking the potential of cell‐permeable nanobodies for intracellular applications

FEBS Letters, EarlyView.
This review outlines current strategies for delivery of nanobodies into cells and highlights recent examples of functional applications. By addressing and manipulating intracellular targets, these molecules hold great potential for treating cancer, respiratory diseases and neurological disorders, making this a vibrant area of research in the biomedical
Mariona Gené‐Verdés, Luise Franz, Christian P.R. Hackenberger   +2 more
wiley   +1 more source

Discovery of the λ Bootis phenomenon in an early B-type star

Astronomy & Astrophysics
Context. Chemically peculiar A-type stars of the λ Boo class are characterised by depletions of refractory elements and normal volatile species. Their formation channel(s) have not yet been fully established, but they provide insight into star-disc ...
Olbermann J., Aschenbrenner P., Przybilla N.   +2 more
doaj   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

An Analysis of Metallic-line Stars with Emission Lines Based on LAMOST

The Astrophysical Journal
Am stars are chemically peculiar A-type stars with weak Ca II K and enhanced metal lines. Emission lines in Am stars are extremely rare and their origin poorly understood.
Yanting He, Haifeng Yang, Jianghui Cai, Yanpu Yin, Chenhui Shi, Meihong Su, Xujun Zhao, Yaling Xun   +7 more
doaj   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

J-PLUS: Identifying Outlier Spectral Energy Distributions in the Fourth Data Release Using Unsupervised Machine Learning

The Astrophysical Journal
The selection of candidates belonging to rare or underrepresented stellar populations, as well as novel objects, is essential for spectroscopic follow-up.
F. Quispe-Huaynasi, F. Roig, V. Loaiza-Tacuri, V. M. Placco, V. Marra, F. Jiménez-Esteban, A. del Pino, B. Anguiano, J. A. Alzate-Trujillo, S. Daflon, C. López-Sanjuan, P. Cruz, A. Alvarez-Candal, E. Machado-Pereira, J. Alcaniz, R. E. Angulo, J. Cenarro, D. Cristóbal-Hornillos, R. Dupke, A. Ederoclite, A. Hernán-Caballero, C. Hernández-Monteagudo, A. Marin-Franch, M. Moles, L. Sodré Jr, J. Varela, H. Vázquez-Ramió, J. Zaragoza-Cardiel   +27 more
doaj   +1 more source