Results 41 to 50 of about 531 (218)

RNA‐related functions of BRCA2 in transcription, replication, and genome stability

FEBS Letters, EarlyView.
Beyond its role in homologous recombination, BRCA2 regulates R‐loop homeostasis, DNA–RNA hybrid resolution, RNA polymerase II dynamics, and transcriptional activation. Disruption of any of these functions can contribute to genome instability, inflammatory signaling, and tumorigenesis. BRCA2 is a central tumor suppressor protein best known for its roles
Lucia Alvaro‐Aranda, Sreerama Chaitanya Sridhara, Aura Carreira   +2 more
wiley   +1 more source

Artificial molecular machines and motors—Design and control of nanoscale motion

FEBS Letters, EarlyView.
Molecules are constantly moving because of thermal fluctuations, but random motion alone cannot be exploited to perform directional tasks. Artificial molecular machines use chemical, electrical, or light energy to bias this motion. Molecular shuttles, rotary motors, and supramolecular pumps illustrate how nanoscale movement can be controlled and ...
Leonardo Andreoni, Alberto Credi
wiley   +1 more source

The metal-poor tail of the APOGEE survey

Astronomy & Astrophysics
Context. Very metal-poor stars are important tracers of the early chemical evolution history of the Milky Way. Infrared H-band spectroscopic surveys, such as APOGEE, are less affected by extinction in the more dust-obscured environments of our Galaxy ...
Montelius M., Angrilli Muglia A., Starkenburg E., Kobayashi C., Ardern-Arentsen A., Gran F., Jablonka P., Martin N., Navarro J., Sestito F., Venn K. A., Vitali S.   +11 more
doaj   +1 more source

The heterodimeric amino acid transporters (HAT) of the SLC7/SLC3 family: A structure−function relationships and relevance to human pathology

FEBS Letters, EarlyView.
Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise, Tiziano Mazza, Raffaella Scanga, Lara Console, Michele Galluccio, Cesare Indiveri   +5 more
wiley   +1 more source

Barium Stars across the Milky Way: Probing Their Origins via the GALAH Survey

The Astrophysical Journal
Barium stars are unusually enriched in barium ([Ba/Fe] ≥ 1.0 dex) and not predicted by current Galactic chemical evolution models. Previous observations of barium stars have found evidence that they form through mass transfer from a companion asymptotic ...
Jaden Levine, Catherine Manea, Keith Hawkins, Kendall Sullivan, Kate H. R. Rubin, Zachary Maas, Andrew C. Nine   +6 more
doaj   +1 more source

A Census of Chemically Peculiar Stars in Stellar Associations

Astronomy
The pre-main-sequence evolution of the chemically peculiar (CP) stars on the upper main sequence is still a vast mystery and not well understood. Our analysis of young associations and open clusters aims to find (very) young CP stars to try to put a ...
Lukas Kueß, Ernst Paunzen
doaj   +1 more source

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source

Discovery of an Extremely r-process-enhanced Thin-disk Star with [Eu/H] = +0.78

The Astrophysical Journal Letters
Highly r -process-enhanced (RPE) stars are rare and usually metal poor ([Fe/H] < −1.0), and they mainly populate the Milky Way halo and dwarf galaxies. This study presents the discovery of a relatively bright ( V = 12.72), highly RPE ( r -II) star ([Eu ...
Xiao-Jin Xie, Jianrong Shi, Hong-Liang Yan, Tian-Yi Chen, Carlos Allende Prieto, Timothy C. Beers, Shuai Liu, Chun-Qian Li, Ming-Yi Ding, Yao-Jia Tang, Ruizhi Zhang, Renjing Xie   +11 more
doaj   +1 more source

Smaller is better: nanobodies meet NMR

FEBS Letters, EarlyView.
Nanobodies are single‐domain antigen‐binding fragments derived from camelid heavy chain antibodies. Their small size, high stability, and exceptional specificity make nanobodies uniquely useful probes for NMR studies of protein dynamics, transient conformational states, and protein–protein interactions.
Oleg Y. Dmitriev
wiley   +1 more source

A Consensus-driven and Physically Validated Catalog of Metallic-line A-star Candidates from LAMOST DR12 Based on Physics-constrained Generative Augmentation with a High-confidence Core of 18,408 Objects

The Astrophysical Journal Supplement Series
We present a consensus-driven and physically validated catalog of 36,226 metallic-line A-star (Am) candidates from LAMOST DR12, constructed by a multimethod framework with physics-constrained generative augmentation, and containing a high-confidence core
Hai-Feng Yang, Yan-pu Yin, Jiang-Hui Cai, Li-Li Wang, Chen-Hui Shi, Yan-Ting He, Mei-Hong Su, Xu-Jun Zhao, Ya-Ling Xun   +8 more
doaj   +1 more source