Results 81 to 90 of about 56,211 (225)

Photoinduzierte Freisetzung maskierter Iridium(III)‐Komplexe für die kombinierte photodynamische und photoaktivierte Chemotherapie

Angewandte Chemie, EarlyView.
Lichtaktivierbare Iridium(III)‐Prodrugs zeigen, wie die Koordination von Chalkogenen die photoinduzierte therapeutische Aktivität steuert. Bei Bestrahlung mit sichtbarem Licht laufen an den schwefel‐ bzw. selenhaltigen Liganden unterschiedliche, sauerstoffabhängige Photoreaktionen ab.
Victoria V. L. Müller, Dominik Moreth, Irene Regeni, Lan Wang, Sylvestre Bonnet, Ulrich Schatzschneider   +5 more
wiley   +1 more source

Der Fried-Prozess als Quelle von 9alpha-Fluorglucocorticoiden

CHIMIA
Das von Josef Fried erfundene Verfahren zur Einführung von 9a-Fluorsubstituenten in Glucocorticoide wirderläutert und ein kurzer Einblick in das Leben dieses bedeutenden Synthetikers und Wirkstoffforschers gegeben.
Carsten A. Vock
doaj   +1 more source

Photogenerated Oxetanes as a Gateway to Uphill Cyclopropanation

Angewandte Chemie International Edition, EarlyView.
An atom‐economical route to densely functionalized cyclopropanes from furans and photochemically activated aldehydes is enabled by a unique oxetane‐to‐cyclopropane rearrangement. These cyclopropanes can be used to access complex bioactive scaffolds and serve as a platform for asymmetric cyclopropane synthesis.
Tim Köglmeier, Thomas J. Tiefel, Oliver Reiser   +2 more
wiley   +1 more source

Defined Dinuclear Nickel Sites on Mesoporous Silica Translate Molecular Surface Mimics to Heterogeneous Catalysis

Angewandte Chemie International Edition, EarlyView.
The cooperative reactivity characteristic of molecular dinuclear nickel complexes is transferred to mesoporous silica through a systematic immobilization strategy. The resulting material preserves the key features of the bimetallic motif within a robust heterogeneous framework, demonstrating how molecular design principles can be translated into well ...
Jitpisut Poolwong, Adrian Jenner, Eric Juriatti, Mustafa Turan, Manfred Manßen   +4 more
wiley   +1 more source

The Jekyll and Hyde Nature of Tetrazoles in Polymer Science: From Intrinsic Electronic Duality to Programmable Macromolecular Function

Angewandte Chemie International Edition, EarlyView.
Tetrazoles are reframed as substitution‐programmable heterocycles rather than static functional groups in polymer chemistry. By linking electronic identity to synthetic strategy and polymer architecture, this mini‐review establishes a design framework for translating tetrazole duality into predictable macromolecular function.
Meryem S. Akdemir, Hatice Mutlu
wiley   +1 more source

Prelog Lecture 2000

CHIMIA, 2001
On Monday, November 13, 2000, the rector, Prof. Dr. K. Osterwalder, presented the Prelog Medal 2000 to Prof. Drs. h.c. Helmut Schwarz, Technische Universität Berlin, Institut für Organische Chemie.
Helmut Schwarz
doaj  

Catalytic C–F Bond Activation at Room Temperature: Enolate Cross‐Couplings Enabled by [Pd(1‐MeNAP)TFA]2 and LiHMDS

Angewandte Chemie International Edition, EarlyView.
Catalysts generated from the trifluoroacetate‐bridged methylnaphthyl‐palladium dimer [Pd(1‐MeNAP)TFA]2 and biarylphosphine ligands in combination with the base LiHMDS promote α‐arylation reactions of various enolates with non‐activated aryl fluorides at room temperature.
Nele Krüger, Jie Shen, Sourav Manna, Lamphiza O. Najiar, Lukas J. Gooßen   +4 more
wiley   +1 more source

Etické a bezpečnostní aspekty využívání ICT ve výuce chemie

Scientia in Educatione, 2016
Informační a komunikační technologie (ICT) jsou v dnešní době nedílnou součástí edukačního procesu. Při jejich používání je mimo efektivity zapotřebí zohledňovat i možná etická a bezpečnostní rizika, která s sebou využívání moderních technologií přináší.
Dagmar Stárková, Martin Rusek
doaj  

In Silico to In Cerebro—Development of the Orexin Receptor Antagonist “Photorexant” for Photomodulation In Vitro and in Mouse Brains

Angewandte Chemie International Edition, EarlyView.
Following a structure‐based design approach, photoswitchable derivatives of the FDA‐approved drug suvorexant were designed, docked, synthesized, and characterized pharmacologically at the orexin 1 and 2 receptors (OX1R and OX2R). Optimized “photorexant” showed up to an 11‐fold difference in IC50 between photoisomers, enabled dynamic and reversible ...
Marcus Angermann, Marie H. Deventer, Vicente Ledesma‐Martin, Nuno Martinho, Alix Flake, Silvia Mori, Angel Nuñez, Jaime Pignatelli, Rita C. Guedes, Christophe P. Stove, Michael Decker   +10 more
wiley   +1 more source

Uncaging Iridium(III) Complexes for Combined Photodynamic and Photoactivated Chemotherapy

Angewandte Chemie International Edition, EarlyView.
Light‐activatable iridium(III) anticancer prodrugs demonstrate how chalcogen coordination controls photoinduced therapeutic activity. Upon visible‐light irradiation, sulfur‐ and selenium‐based caging ligands undergo distinct oxygen‐dependent photoreactions that trigger ligand release and singlet oxygen generation, enabling combined photoactivated ...
Victoria V. L. Müller, Dominik Moreth, Irene Regeni, Lan Wang, Sylvestre Bonnet, Ulrich Schatzschneider   +5 more
wiley   +1 more source