Results 51 to 60 of about 11,492,440 (323)

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Identification and pharmacological inactivation of the MYCN gene network as a therapeutic strategy for neuroblastic tumor cells [PDF]

, 2015
This research was originally published in Journal of Biological Chemistry. Olesya Chayka, Cosimo Walter D’Acunto, Odette Middleton, Maryam Arab, and Arturo Sala.
Arab, M, Chayka, O, D'Acunto, CW, Middleton, O, Sala, A   +4 more
core   +1 more source

Routine clinical chemistry and haematological test reference intervals for healthy adults in the Bhutanese population.

PLoS ONE, 2022
Laboratory medicine plays a critical role in the modern healthcare system, and it is reported to influence 60-70% of clinical decision makings. The quantitative laboratory test results are interpreted by comparing to the Reference Intervals (RIs) and ...
Kuenzang Dorji, Sonam ChhodenR, Kinley Wangchuk, Sonam Zangpo, Shacha Tenzin, Chenga Dawa, Puja Devi Samal, Nima, Jigme Tshering, Choney Wangmo, Sonam Zangpo, Kinley Dorji, Sonam Tshewang   +12 more
doaj   +1 more source

The Essential Medicinal Chemistry of Curcumin

Journal of Medicinal Chemistry, 2017
Curcumin is a constituent (up to ∼5%) of the traditional medicine known as turmeric. Interest in the therapeutic use of turmeric and the relative ease of isolation of curcuminoids has led to their extensive investigation.
Kathryn M. Nelson, Jayme L. Dahlin, J. Bisson, J. Graham, G. Pauli, M. Walters   +5 more
semanticscholar   +1 more source

Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10

FEBS Letters, EarlyView.
Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang, Satoshi Hashimoto, Sota Ito, Chisato Kikuguchi, Miho Hoshi, Kiyoshi Yamaguchi, Yoichi Furukawa, Toru Suzuki, Toshifumi Inada   +8 more
wiley   +1 more source

Diagnostic accuracy of calculated serum osmolarity to predict dehydration in older people: adding value to pathology lab reports [PDF]

, 2015
Objectives: To assess which osmolarity equation best predicts directly measured serum/plasma osmolality and whether its use could add value to routine blood test results through screening for dehydration in older people. Design: Diagnostic accuracy study
American Medical Directors Association (AMDA), Berendson, Bhalla, Bland, Bohnen, Bossuyt, Burnett, Cheuvront, Cheuvront, Cheuvront, Cheuvront, Deardorff, Dimeski, Edelman, El-Sharkawy, Fazekas, Fortes, Gerich, Heavens, Hoffman, Hooper, Hooper, Institute of Medicine, Johnson, Kafri, Khajuria, Koga, Kyle, Levey, Longmore, Naitoh, Olde Rikkert, Perrier, Pfortmueller, Redetzki, Santoro, Seifarth, Siervo, Sjöstrand, Stookey, Stookey, Stookey, Thomas, Thomas, Vivanti, Wachtel, Zweig   +46 more
core   +1 more source

Using heparin tube for clinical chemistry, an application of evacuated blood collection system

Journal of Health Science and Medical Research (JHSMR), 2003
Heparin is a common blood anticoaulant. The heparinized vacuum tube is an application of the evacuated blood collection system. Using the vacuum heparinized tubes can bring similar results compared to the routine plain tubes for clinical chemistry ...
V Wiwanitkit
doaj  

Peptide‐based ligand antagonists block a Vibrio cholerae adhesin

FEBS Letters, EarlyView.
The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang, Grace Du, Charity Yongo‐Luwawa, Angelina Lu, Brett Kinrade, Kim Munro, Karl E. Klose, William D. Lubell, Peter Davies, Shuaiqi Guo   +9 more
wiley   +1 more source

In Vivo Imaging of Transplanted Islets with ^(64)Cu-DO3A-VS-Cys^(40)-Exendin-4 by Targeting GLP-1 Receptor [PDF]

, 2011
Glucagon-like peptide 1 receptor (GLP-1R) is highly expressed in pancreatic islets, especially on β-cells. Therefore, a properly labeled ligand that binds to GLP-1R could be used for in vivo pancreatic islet imaging.
Bading, James R., Colcher, David, Conti, Peter E., Fraser, Scott E., Ishiyama, Kohei, Kandeel, Fouad, Li, Lin, Li, Zibo, Nair, Indu, Shively, John E., Todorov, Ivan, Wu, Zhanhong   +11 more
core   +2 more sources

Trends in Clinical Chemistry

CHIMIA, 2000
Analytical chemistry and clinical chemistry have come closer together over the past thirty years and increasingly profit from each other.
Ursula E. Spichiger-Keller
doaj