Results 41 to 50 of about 8,108,131 (288)

Agarose gel electrophoresis: Applications in clinical chemistry [PDF]

Journal of Medical Biochemistry, 2010
Agarose gel electrophoresis is a well established technique routinely used in clinical laboratories for screening protein abnormalities in various biological fluids (serum, urine, CSF).
Giot Jean-Francois
doaj  

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Reference data of clinical chemistry, haematology and blood coagulation parameters in juvenile cynomolgus monkeys (Macaca fascicularis)

Veterinární Medicína, 2012
Juvenile cynomolgus monkeys are valuable models for studying human diseases. Reference data of clinical chemistry, haematology and blood coagulation parameters of juvenile cynomolgus monkeys are very important for clinical diagnosis and conducting ...
H. Wang, Y.Y. Niu, W. Si, Y.J. Li, Y. Yan   +4 more
doaj   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Pre-Analytical Considerations in Clinical Chemistry

Journal of Associated Medical Sciences, 2015
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Sheshadri Narayanan
doaj  

Assessment of Selected Clinical Chemistry Analytes Among Hypertensive Patients at Wallaga University Referral Hospital, Nekemte, Oromia, Western Ethiopia: A Comparative Cross‐Sectional Study

Health Science Reports
Background and Aims Hypertension (HTN) is a long‐term condition marked by consistently high arterial blood pressure. It is a leading contributor to cardiovascular diseases and early mortality around the globe.
Amanuel Hika, Sintayehu Asaye Biya, Temam Ibrahim Husen, Negesse Bokona Rufe, Hundesa Emana Urgesa, Bedasa Addisu   +5 more
doaj   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

Clinical Chemistry and Autoverification: A Path Less Traversed [PDF]

Indian Journal of Medical Biochemistry
Aims and background: Autoverification (AV) is an application of artificial intelligence that uses computer-based algorithmically established rules for release of patient reports. This allows effective time management, prevents probable laboratory errors,
Rashmi Rasi Datta, Anurag Bansal
doaj   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Dynamic Combinatorial Libraries: From Exploring Molecular Recognition to Systems Chemistry [PDF]

, 2013
Dynamic combinatorial chemistry (DCC) is a subset of combinatorial chemistry where the library members interconvert continuously by exchanging building blocks with each other.
Otto, Sijbren,, Otto, Sijbren; id_orcid, Jianwei Li, Nowak, Piotr,, Li, Jianwei,, Piotr Nowak, Sijbren Otto, Otto, Sijbren, Li, Jianwei, Nowak, Piotr   +9 more
core   +1 more source