Results 41 to 50 of about 303,590 (193)
A personal perspective on medicinal and pharmaceutical chemistry [PDF]
Frontiers in Chemistry, 2014 The search for new organic and inorganic compounds for treatment of different types of diseases is the aim of intense study. Over the past decades, many new compounds have been synthesized and isolated from numerous sources. However, only a fraction of them have demonstrated activity against human diseases.
openaire +3 more sources
TRPM8 levels determine tumor vulnerability to channel agonists
Molecular Oncology, EarlyView.TRPM8 is a Ca2+ permissive channel. Regardless of the amount of its transcript, high levels of TRPM8 protein mark different tumors, including prostate, breast, colorectal, and lung carcinomas. Targeting TRPM8 with channel agonists stimulates inward calcium currents followed by emptying of cytosolic Ca2+ stores in cancer cells.
Alessandro Alaimo +18 more
wiley +1 more source
Molecular Oncology, EarlyView.In patients treated with atezolizumab as a part of the MyPathway (NCT02091141) trial, pre‐treatment ctDNA tumor fraction at high levels was associated with poor outcomes (radiographic response, progression‐free survival, and overall survival) but better sensitivity for blood tumor mutational burden (bTMB).
Charles Swanton +17 more
wiley +1 more source
Geographic proximity and firm-university innovation linkages: evidence from Great Britain [PDF]
, 2008 We investigate evidence for spatially mediated knowledge transfer from university research. We examine whether firms locate their R&D labs near universities, and whether those that do are more likely to co-operate with, or source knowledge from ...
Abramovsky, L., Simpson, H.
core
, 2022 Pharmaceutical analysis, as the core curriculum of chemistry, chemical engineering and pharmaceutical engineering, contains broad and in-depth knowledge that leads to massive learning & teaching loads.
Cao, Jun +4 more
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To find, make, and study drugs for medical use, pharmaceutical chemistry is a mixed science that brings together parts of chemistry, biology, and pharmacology. Pharmaceutical chemistry is important to understand if you want to make medicines that work and are safe, make sure they are of good quality, and study how they work.
Dr. Gomathi Periyasamy +4 more
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Molecular Oncology, EarlyView.Trastuzumab‐deruxtecan, a HER2‐targeting antibody‐drug conjugate, shows promising antitumor activity in head and neck squamous cell carcinoma with low HER2 expression. In vitro and in vivo studies demonstrated dose‐dependent cell death and tumor growth reduction in low HER2‐expressing cell lines, which correlated with drug accumulation measured using a
Abdullah Bin Naveed +8 more
wiley +1 more source
Molecular Oncology, EarlyView.Comprehensive cancer centre (CCCs) and CCCs of Excellence (CCCoE) integration in healthcare. Through outreach to surrounding community hospitals, CCCs enable wider access to top‐clinical cancer treatments and care, thereby facilitating the swift enrolment of patients into data‐rich clinical trials (PI‐initiated trials testing new concepts, drug ...
Anton Berns +4 more
wiley +1 more source
Recent advances in pharmaceutical sciences VII [PDF]
, 2017 The E-book series Recent Advances in Pharmaceutical Sciences reports research contributions from different areas of the multidisciplinary field of Pharmaceutical Sciences.
Feliu José, Carlos +2 more
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Prediction of the permeability of neutral drugs inferred from their solvation properties [PDF]
, 2015 Determination of drug absorption is an important component of the drug discovery and development process in that it plays a key role in the decision to promote drug candidates to clinical trials.
Milanetti, Edoardo +2 more
core +1 more source