Results 61 to 70 of about 10,692 (235)

Advances in PARP Inhibition in Improving Outcomes of Breast Cancer, Ovarian Cancer, and Other Solid Tumors: Journey of Discovery, Development, and Clinical Updates of Talazoparib

Drug Design, Development and Therapy
Muhammad Latif,1– 3 Sana Mazhar,4,5,* Mussarat Tasleem,6,* Abdulmajeed Alqurashi,7 Muhammad Arfan,8 Zaman Ashraf,3 Muhammad Sohail Zafar9– 11 1Centre for Genetics and Inherited Diseases (CGID), Taibah University, Madinah, 42353, Kingdom ...
Latif M, Mazhar S, Tasleem M, Alqurashi A, Arfan M, Ashraf ‎Z, Zafar MS   +6 more
doaj  

Emerging Antimicrobial Drug Resistance in Africa and Latin America: Search for Reasons

Risk Management and Healthcare Policy, 2022
Ludwig Hoellein,1 Eliangiringa Kaale,2 Yonah Hebron Mwalwisi,3 Marco H Schulze,4 Carina Vetye-Maler,5 Ulrike Holzgrabe1 1Institute for Pharmacy and Food Chemistry, Julius-Maximilians-Universität Würzburg, Würzburg, Germany; 2Muhimbili University of ...
Hoellein L, Kaale E, Hebron Mwalwisi Y, Schulze MH, Vetye-Maler C, Holzgrabe U   +5 more
doaj  

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

FEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil, Anna Corrà, Annalisa Scapolatiello, Chengxiang Qiu, Gianluca Amadei   +4 more
wiley   +1 more source

An electrochemical aptamer-based biosensor for rapid and ultrasensitive detection of carbaryl by red blood cell-like MOFs

Alexandria Engineering Journal
Carbaryl (CBA) is a broad-spectrum carbamate insecticide widely used to control pests on crops, trees, and ornamental plants. CBA residues in foods can accumulate in the human body and damage human health, making it challenging to develop a sensitive and
Hossein Khosropour, Mansoureh Keramat, Vitsarut Primpray, Chanpen Karuwan, Federico Tasca, Wanida Laiwattanapaisal   +5 more
doaj   +1 more source

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

FEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure, Misaki K. Nishio, Satoru Okuda, Kohji Hotta   +3 more
wiley   +1 more source

Revolutionizing melamine detection: Cutting-edge advances from traditional analyses to state-of-the-art electrochemical sensors

Next Materials
The scientific community has struggled to monitor harmful and toxic chemicals with the goal of improving both human health and the environment. Melamine (1, 3, 5-triazine-2, 4, 6-triamine, C3H6N6) is a cyanamide trimer used primarily to produce plastics,
Rupali P. Kalambate, Pramod K. Kalambate, Wanida Laiwattanapaisal   +2 more
doaj   +1 more source

Acanthus ebracteatus leaf extract provides neuronal cell protection against oxidative stress injury induced by glutamate

BMC Complementary and Alternative Medicine, 2018
Background Acanthus ebracteatus (AE), an herb native to Asia, has been recognized in traditional folk medicine not only for its antioxidant properties and various pharmacological activities but also as an ingredient of longevity formulas.
Anchalee Prasansuklab, Tewin Tencomnao
doaj   +1 more source

Biophysical approaches for studying viral entry

FEBS Letters, EarlyView.
Viruses infect all living organisms and have been responsible for major epidemics and pandemics. Their ongoing evolutionary battle with host defenses creates a constant need for improved tools to study viral behavior. Advancing methods to probe viral attachment, fusion, and genome release deepen our understanding of how infections begin and support the
Inbar Yosibash, Raya Sorkin
wiley   +1 more source

Sex-specific impacts of prenatal bisphenol A exposure on genes associated with cortical development, social behaviors, and autism in the offspring’s prefrontal cortex

Biology of Sex Differences
Background Recent studies have shown that prenatal BPA exposure altered the transcriptome profiles of autism-related genes in the offspring’s hippocampus, disrupting hippocampal neuritogenesis and causing male-specific deficits in learning.
Songphon Kanlayaprasit, Thanit Saeliw, Surangrat Thongkorn, Pawinee Panjabud, Kasidit Kasitipradit, Pattanachat Lertpeerapan, Kwanjira Songsritaya, Wasana Yuwattana, Thanawin Jantheang, Depicha Jindatip, Valerie W. Hu, Takako Kikkawa, Noriko Osumi, Tewarit Sarachana   +13 more
doaj   +1 more source