Results 71 to 80 of about 7,060,757 (314)

Characterizing Uncertainty in Machine Learning for Chemistry

Journal of Chemical Information and Modeling, 2023
Characterizing uncertainty in machine learning models has recently gained interest in the context of machine learning reliability, robustness, safety, and active learning. Here, we separate the total uncertainty into contributions from noise in the data (aleatoric) and shortcomings of the model (epistemic), further dividing epistemic uncertainty into ...
Esther Heid, Charles McGill, Florence H. Vermeire, William H. Green Jr.   +3 more
openaire   +4 more sources

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Systematic literature review on the application of Problem-Based Learning model in chemistry education

Eclética Química
Problem-based learning (PBL) has seen significant growth in recent years, but its effective implementation remains a challenge. Therefore, this study undertakes a systematic literature review to synthesise the research patterns, challenges, and ...
Fauzana Gazali, Sri Rahayu, Munzil Munzil, Surjani Wonorahardjo, Muhammad Dimar Alam   +4 more
doaj   +1 more source

Pengembangan Alat Ukur Tingkat Efikasi Diri Siswa dalam Pembelajaran Kimia

Jurnal Pengukuran Psikologi dan Pendidikan Indonesia, 2020
This study aims to develop a student self-efficacy scale in learning, especially in chemistry learning. This scale has been developed with 4 main steps, namely the determination of aspects, preparation of indicators, preparation of statement items and ...
Febrian Solikhin
doaj   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Multiple representation-based chemistry learning textbook of colloid topic

, 2021
This study aimed to describe the differences in students’ learning outcomes using the multiple representation-based chemistry learning textbook and the conventional chemistry learning textbook. This study was a quasi-experimental research. The population
K. Widiastari, I. W. Redhana
semanticscholar   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

STUDENT DIFFICULTY ANALYSIS IN COMPLETING CHEMISTRY ODD SEMESTER EXAM

JTK (Jurnal Tadris Kimiya), 2020
The problems obtained by the researcher in Senior High School 5 Takengon Central Aceh show that most students have difficulty solving odd semester exam questions in chemistry learning. This study aims to determine what difficulties students face and what
Mujakir Mujakir, Haris Munandar, Nur Fitri Hidayati   +2 more
doaj   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source