Results 11 to 20 of about 142,491 (231)

Antihypoxic Activity of 2,5-diaryl-8,8-dimethyl-3,6,7,8-tetrahydro-2H-pyrido[4,3,2-de]quinnolin-3-ones

Разработка и регистрация лекарственных средств, 2022
Introduction. The state of hypoxia, causing damage and cell death, underlies many pathological processes. In addition, hypoxia induces a state of free radical oxidation, which enhances the damaging effect of hypoxic damage.
S. S. Zykova, K. V. Namyatova, K. L. Gankova, E. A. Lystsova, T. V. Shavrina, S. N. Shurov   +5 more
doaj   +1 more source

Chloramine-T (N-chloro-p-toluenesulfonamide sodium salt), a versatile reagent in organic synthesis and analytical chemistry: An up to date review

Journal of Saudi Chemical Society, 2022
Chloramine-T (CAT), the sodium salt of N-chloro-p-toluenesulfonamide, is a low-cost mild oxidizing agent with a wide range of uses. Most importantly, it can be used in acidic, neutral, and basic conditions. As a result, it’s been widely used in chemistry,
Yogeesha N. Nayak, Santosh L. Gaonkar, Ebraheem Abdu Musad Saleh, Abdullah Mohammed A.L. Dawsari, Harshitha, Kakul Husain, Ismail Hassan   +6 more
doaj   +1 more source

Versatile Monitoring Tools in Parallel Solid-Phase Synthesis

CHIMIA, 2003
Parallel synthesis on solid-phase is routinely applied in our combinatorial chemistry efforts for lead finding and lead optimization in drug discovery.
Eduard R. Felder, Katia Martina, Simona Scarpella, Marco Tatò   +3 more
doaj   +1 more source

Exploring chemoselective S-to-N acyl transfer reactions in synthesis and chemical biology

Nature Communications, 2017
The conversion of thioesters to amides via acyl transfer has become one of the most important synthetic techniques for the chemical synthesis and modification of proteins.
Helen M. Burke, Lauren McSweeney, Eoin M. Scanlan   +2 more
doaj   +1 more source

Smart Ligands for Efficient 3d-, 4d- and 5d-Metal Single-Molecule Magnets and Single-Ion Magnets

Inorganics, 2020
There has been a renaissance in the interdisciplinary field of Molecular Magnetism since ~2000, due to the discovery of the impressive properties and potential applications of d- and f-metal Single-Molecule Magnets (SMMs) and Single-Ion Magnets (SIMs) or
Panagiota S. Perlepe, Diamantoula Maniaki, Evangelos Pilichos, Eugenia Katsoulakou, Spyros P. Perlepes   +4 more
doaj   +1 more source

Inhibition of platelet adhesion, thrombus formation, and fibrin formation by a potent αIIbβ3 integrin inhibitor from ticks

Research and Practice in Thrombosis and Haemostasis, 2021
Background Ticks puncture the skin of their hosts and secrete saliva, containing antiplatelet proteins, into the blood. Here, we studied disagregin, a potent platelet‐inhibiting protein derived from the salivary glands of Ornithodoros moubata, an African
Danique L. van denKerkhof, Magdolna Nagy, Kanin Wichapong, Sanne L.N. Brouns, Johan W. M. Heemskerk, Tilman M. Hackeng, Ingrid Dijkgraaf   +6 more
doaj   +1 more source

The Role of Synthetic Organic Electrochemistry in the Technological Revolution of Pharmaceutical Industry

CHIMIA
Electrochemistry is significantly contributing to the technological revolution of organic synthesis, where the implementation of different techniques has garnered innovative and scalable synthetic methodologies.
Gabriele Laudadio
doaj   +1 more source

Polymers Interfacing with Biology

CHIMIA, 2011
The development of various controlled radical polymerization techniques as well as site- and residue specific strategies to modify peptides/proteins with synthetic polymers have made polymer chemistry a powerful tool to address materials ...
Frederik Wurm, Harm-Anton Klok
doaj   +1 more source

Redesigning Life: Organic Chemistry and the Evolving Protein

CHIMIA, 1987
Techniques from synthetic chemistry, enzymology, and molecular biology are now making it possible to prepare sizeable amounts of proteins whose amino acid sequences have been systematically altered.
Steven A. Benner
doaj   +1 more source

Controlling the Chemistry of Nanoclusters: From Atomic Precision to Controlled Assembly

Nanomaterials, 2021
Metal nanoclusters have gained prominence in nanomaterials sciences, owing to their atomic precision, structural regularity, and unique chemical composition.
Srestha Basu, Anumita Paul, Rodolphe Antoine   +2 more
doaj   +1 more source