Results 101 to 110 of about 5,044 (221)

Integrated spherical nucleic acid nanoreactor mobilizes targeted PD‐L1 proteolysis and cuproptosis for robust breast cancer immunotherapy

BMEMat, EarlyView.
This study provides an integrated spherical nucleic acid nanoreactor (denoted as AMCuD) for targeted PD‐L1 degradation and chemo‐dynamically enhanced cuproptosis to synergically elicit robust immunotherapy against the triple‐negative breast cancer (TNBC) growth, recurrence and metastasis.
Ningxi Li, Honglin Huang, Qianyi Zeng, Li Zeng, Ziman Yang, Jinyang Shen, Shun Li, Hong Yang, Yiyao Liu, Chunhui Wu   +9 more
wiley   +1 more source

Synergistic chemodynamic-photothermal therapy of super-resistant Enterobacter asburiae-infected sepsis using multifunctional mesoporous nanocomposite

Journal of Nanobiotechnology
Multidrug-resistant bacterial infections pose a severe threat to sepsis, where uncontrolled bacterial proliferation and the accompanying inflammatory response lead to multiorgan dysfunction.
Anlai Zou, Xiaoxue Zhu, Feng Zhao, Jinjie Hou, Mengliu Zhao, Ting Yu, Junzheng Zhang, Ying Fu, Zhi Ruan, Yunlei Xianyu, Jun Zhang   +10 more
doaj   +1 more source

Boron Neutron Capture Therapy at a Crossroads: Translational Gap and Emerging Delivery Agents

Chemistry – A European Journal, EarlyView.
This review surveys recent advances in boron delivery agents for BNCT, emphasizing the shift from classical small molecules to multifunctional nanocarriers and theranostic systems. By integrating targeting, imaging, and therapy, next‐generation boron compounds aim to bridge the gap between (bio)chemical innovation and clinical translation.
Christoph Selg, Evamarie Hey‐Hawkins
wiley   +1 more source

Multicomponent Transition Metal Dichalcogenide Nanosheets for Imaging‐Guided Photothermal and Chemodynamic Therapy [PDF]

, 2020
Transition metal dichalcogenides (TMDs) have received considerable attention due to their strong absorption in the near‐infrared (NIR) region, strong spin‐orbit coupling, and excellent photothermal conversion efficiency (PCE).
Fu, L, Liang, R, Wang, H, Wang, Y, Wei, M, Weng, X, Williams, GR, Wu, J, Zhu, Y   +8 more
core  

The scale matters: A review on stimuli‐responsive microrobots categorized by scale for biomedical applications

Responsive Materials, EarlyView.
We systematically summarize how each scale dictates fundamental choices in design feature, manufacturing technology, driving mechanism, and control strategy, which are inherently governed by scale‐dominated physical principles. Furthermore, the application of scale‐determined operation modes of microrobots across different stages of medical ...
Hang Yin, Yujing Li, Guanghao Wu, Yubing Guo   +3 more
wiley   +1 more source

Cascade Hydroxyl Radical-Generating and Ferroptosis-Inducing Nanofiber System for the Therapy of Oral Squamous Cell Carcinoma

Molecules
Nanofiber (NF) membrane systems that can provide cascade catalytic reaction and ferroptosis induction were developed for oral cancer therapy. Glucose oxidase (GOx) and aminoferrocene (AF) were introduced into the NF system for glucose deprivation/H2O2 ...
JiHye Park, Qiaojun Hao, Da In Jeong, Hyun-Jin Kim, Sungyun Kim, Song Yi Lee, Seongnam Chu, Usok Hyun, Hyun-Jong Cho   +8 more
doaj   +1 more source

Interfacial Chemistry‐Tailored Silica&Metal‐Based Heterostructures: from Rational Design to Antibacterial Applications

Small, EarlyView.
This review explores how interfacial engineering of silica&metal‐based nanohybrids enables precise architectural control, leveraging the structural and functional contributions of silica to overcome the inherent limitations of meta‐based materials. The antibacterial performance of these nanohybrids including membrane disruption, stimuli‐responsive ...
Dan Cheng, Yuchao Gu, Chengzhong Yu
wiley   +1 more source

Reactive oxygen species switcher via MnO 2-coated Prussian blue loaded hyaluronic acid methacrylate hydrogel microspheres for local anti-tumor treatment. [PDF]

ROS-induced therapy can eradicate breast tumors when combined with thermal ablation, but excessive ROS also threatens peritumoral tissue with inflammation.
Bártolo, Raquel, Cai, Zhengwei, Chen, Jie, Chen, Liang, Chen, Yu, Cui, Wenguo, Du, Yawei, Han, Huijie, Li, Jiachen, Santos, Hélder A, Shahbazi, Mohammad-Ali, Wang, Shiqi, Zuhorn, Inge S   +12 more
core   +1 more source

External Stimuli‐Activable Single‐Atom Nanozymes for Bioapplications

Small, EarlyView.
Stimuli‐activable single‐atom nanozymes (SANs) are reviewed from materials design to biomedical applications. We explain electronic‐structure tuning principles and synthesis strategies that maximize the responsiveness of metal active sites and supports to light, ultrasound, and magnetic fields.
Hyun Ko, Jungsue Choi, Hyeonjeong Noh, Sohyeon Seo, Heedong Kwon, Seungjune Lee, Hyoyoung Lee   +6 more
wiley   +1 more source

A general and green approach of pH‐sensitive ZIF‐67 for encapsulating active substances

Smart Molecules, EarlyView.
Zeolitic imidazolate framework‐67 (ZIF‐67) was successfully synthesized in deionized water for 2 h in this work; meanwhile, various active substances could be encapsulated in one‐pot with the same process, resulting in high loading rates. The study delved into the growth mechanism, morphological difference and loading capacity.
Xinyi Sun, Yan Qi, Xinhao Che, Lulu Zhou, Yuxin Li, Lei Zhang, Jing Hu   +6 more
wiley   +1 more source