Results 1 to 10 of about 432,621 (308)

Nanoparticle-Based Delivery Systems for Synergistic Therapy in Lung Cancers [PDF]

Bioengineering
Lung cancer remains the leading cause of cancer-related mortality worldwide, with conventional treatments often limited by systemic toxicity, different tumor sensitivity to the drugs, and the emergence of multidrug resistance. To address these challenges,
Zicheng Deng, Ali Al Siraj, Isabella Lowry, Ellen Ruan, Rohan Patel, Wen Gao, Tanya V. Kalin, Vladimir V. Kalinichenko   +7 more
doaj   +2 more sources

Evidence for Two Modes of Synergistic Induction of Apoptosis by Mapatumumab and Oxaliplatin in Combination with Hyperthermia in Human Colon Cancer Cells [PDF]

, 2013
Colorectal cancer is the third leading cause of cancer-related mortality in the world-- the main cause of death from colorectal cancer is hepatic metastases, which can be treated with isolated hepatic perfusion (IHP).
A Jemal, A Krueger, A Krueger, A Younes, AR Safa, BR Seo, C Liu, C Odoux, CH Mom, D Atallah, D Mahalingam, DB Longley, E Raymond, FA Greco, GJ Ullenhag, HJ Zeh 3rd, HR Alexander Jr., IA Mawji, IN Lavrik, J Yoo, JA Ubersax, JM Cummins, JW Yu, L Zhang, L Zhao, LR Hafström, LY Dimberg, M Irmler, M Upreti, M Vulfovich, MA Alcala Jr., MJ Lee, P Korkolopoulou, Raffaele A Calogero, S Hegewisch-Becker, S Varghese, Seog-Young Kim, SK Libutti, T Bartke, T Ruers, T Trarbach, TR Wilson, W Gao, X Song, X Song, X Song, Xinxin Song, Y Jin-Song, Y Lin, YJ Lee, YL Zhang, Yong J. Lee, Z El Fajoui   +52 more
core   +15 more sources

Synergistic neuroprotective therapies with hypothermia [PDF]

Seminars in Fetal and Neonatal Medicine, 2010
Neuroprotection is a major health care priority, given the enormous burden of human suffering and financial cost caused by perinatal brain damage. With the advent of hypothermia as therapy for term hypoxic-ischemic encephalopathy, there is hope for repair and protection of the brain after a profound neonatal insult.
Maria Roberta, Cilio, Donna M, Ferriero
openaire   +2 more sources

Intelligent Nanoparticles With pH-Sensitive Co-Delivery of Temozolomide and siEGFR to Ameliorate Glioma Therapy

Frontiers in Genetics, 2022
Glioblastoma (GBM) is one of the most lethal forms of human cancer, with very few long-term survivors. In addition to surgery, chemotherapy is still an important strategy.
Zhen Wang, Yuyang Liu, Yong Xiao, Yandong Xie, Ran Wang, Yiding Zhang, Qi Zhou, Liang Liu, Shuo Sun, Hong Xiao, Yuanjie Zou, Kun Yang, Xiang Li, Mengjie Zhao, Yifang Hu, Hongyi Liu   +15 more
doaj   +1 more source

Synergistic antimicrotubule therapy for prostate cancer [PDF]

Biochemical Pharmacology, 2011
Prostate cancer has been widely viewed as a chemoresistant neoplasm. Perhaps, the most prevalent antimicrotubule strategy involves docetaxel administration at its maximum-tolerated dose (MTD). Although the goal is to obtain total eradication of cancer cells, debilitating toxicities are presented by docetaxel therapy, including myelosuppression ...
Vaishali, Pannu, Prasanthi, Karna, Hari Krishna, Sajja, Deep, Shukla, Ritu, Aneja   +4 more
openaire   +2 more sources

Synergistic Therapeutic Effects of Low Dose Decitabine and NY-ESO-1 Specific TCR-T Cells for the Colorectal Cancer With Microsatellite Stability

Frontiers in Oncology, 2022
Patients of colorectal cancer (CRC) with microsatellite stability (MSS) show poor clinical response and little beneficial result from the immune-checkpoint inhibitors, due to the ‘cold’ tumor microenvironment.
Ganjun Yu, Wenying Wang, Xiaobo He, Jia Xu, Rongrong Xu, Tao Wan, Yanfeng Wu   +6 more
doaj   +1 more source

Organic Photodynamic Nanoinhibitor for Synergistic Cancer Therapy [PDF]

Angewandte Chemie International Edition, 2019
AbstractDespite its great potential in cancer treatment, photodynamic therapy (PDT) often exacerbates hypoxia and subsequently compromises its therapeutic efficacy. To overcome this issue, an organic photodynamic nanoinhibitor (OPNi) has been synthesized that has the additional ability to counteract carbonic anhydrase IX (CA‐IX), a molecular target in ...
Yuyan Jiang, Jingchao Li, Ziling Zeng, Chen Xie, Yan Lyu, Kanyi Pu   +5 more
openaire   +3 more sources

Synergistic cortisol suppression by ketoconazole–osilodrostat combination therapy [PDF]

Endocrinology, Diabetes & Metabolism Case Reports, 2021
Summary Here, we describe a case of a patient presenting with adrenocorticotrophic hormone-independent Cushing’s syndrome in a context of primary bilateral macronodular adrenocortical hyperplasia. While initial levels of cortisol were not very high, we could not manage to control hypercortisolism with ketoconazole monotherapy, and could not increase ...
Amodru, Vincent, Brue, Thierry, Castinetti, Frederic   +2 more
openaire   +3 more sources

A NIR‐II Photoactivatable “ROS Bomb” with High‐Density Cu2O‐Supported MoS2 Nanoflowers for Anticancer Therapy

Advanced Science, 2023
The fast conversion of hydrogen peroxide (H2O2) into reactive oxygen species (ROS) at tumor sites is a promising anticancer strategy by manipulating nanomedicines with near‐infrared light in the second region (NIR‐II).
Jia Huang, Guiming Deng, Shuya Wang, Tianjiao Zhao, Qiaohui Chen, Yuqi Yang, Yongqi Yang, Jinping Zhang, Yayun Nan, Zhaoqian Liu, Ke Cao, Qiong Huang, Kelong Ai   +12 more
doaj   +1 more source

Glucose Oxidase‐Instructed Multimodal Synergistic Cancer Therapy [PDF]

Advanced Materials, 2019
AbstractOver the past 3 years, glucose oxidase (GOx) has aroused great research interest in the context of cancer treatment due to its inherent biocompatibility and biodegradability, and its unique catalytic properties against β‐d‐glucose. GOx can effectively catalyze the oxidation of glucose into gluconic acid and hydrogen peroxide.
Lian‐Hua Fu, Chao Qi, Yan‐Ru Hu, Jing Lin, Peng Huang   +4 more
openaire   +3 more sources