Results 21 to 30 of about 432,621 (308)
Progress of PD-1/PD-L1 Inhibitors in Non-small Cell Lung Cancer
Chinese Journal of Lung Cancer, 2017 Pembrolizumab, an inhibitor target programmed death 1 (PD-1), was approved into the first line therapy in advanced non-small cell lung cancer (NSCLC). It was a milestone that immune checkpoints drugs have played an important role in the treatment system ...
Zhansheng JIANG, Zhanyu PAN, Xiubao REN
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Frontiers in Bioengineering and Biotechnology, 2023 A novel drug delivery system for the treatment of oral cancer was developed using a facile polydopamine (PDA)-based surface modification and a binding mechanism linking folic acid-targeting ligands. The system was able to achieve the following objectives:
Xingyong Yin +6 more
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Photodynamic Therapy Combined with Ferroptosis Is a Synergistic Antitumor Therapy Strategy
Cancers, 2023 Ferroptosis is a programmed death mode that regulates redox homeostasis in cells, and recent studies suggest that it is a promising mode of tumor cell death. Ferroptosis is regulated by iron metabolism, lipid metabolism, and intracellular reducing substances, which is the mechanism basis of its combination with photodynamic therapy (PDT). PDT generates
Huang, Yunpeng +5 more
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Advanced Science, 2023 The effective and targeted treatment of resistant cancer cells presents a significant challenge. Targeting cell ferroptosis has shown remarkable efficacy against apoptosis‐resistant tumors due to their elevated iron metabolism and oxidative stress levels.
Pingjin Zou +10 more
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Multi-drug resistant Gram-negative bacteria: antibiotic-resistance and new treatment strategies [PDF]
, 2017 In this editorial, we treat the multi-drug-resistance of microorganisms such as Klebsiella pneumonia (Kp) and Acinetobacter baumanii and the issues concerning the management of these infections.
Angelis, Massimiliano De +2 more
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In-vitro evaluation of different antimicrobial combinations with and without colistin against carbapenem-resistant acinetobacter baumannii [PDF]
, 2019 Carbapenem-resistant Acinetobacter baumannii (CR-Ab) infections are associated with high morbidity and mortality. The aim of the study was to evaluate the in-vitro activity of different antimicrobial combinations (with and without colistin, COL) against ...
De Angelis, Massimiliano +6 more
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International Journal of Nanomedicine, 2023 Na Li,1 Xiaochun Jiang,2 Wanju Zhang,1 Wenping Xiao,1 Zhaona Wu,1 Huirong Wang,1 Feng He1 1Li Shizhen College of Traditional Chinese Medicine, Huanggang Normal University, Huanggang, 438000, People’s Republic of China; 2Hubei Key Laboratory for ...
Li N +6 more
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BH3 mimetic ABT-737 sensitizes colorectal cancer cells to ixazomib through MCL-1 downregulation and autophagy inhibition. [PDF]
, 2016 The proteasome inhibitor MLN9708 is an orally administered drug that is hydrolyzed into its active form, MLN2238 (ixazomib). Compared with Bortezomib, MLN2238 has a shorter proteasome dissociation half-life and a lower incidence and severity of ...
Barkhouse, Darryll +7 more
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Drug Delivery, 2019 Protein-based nanocarriers with inherent biocompatibility have been widely served as building blocks to construct versatile therapeutic nanoplatforms.
Wenguang Gu +8 more
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Di-san junyi daxue xuebao, 2021 Objective To prepare iridium oxide (IrOX) as a nano-sonosensitizer to load chemotherapy drug doxorubicin (DOX) in order to obtain nanocomposites IrOX@DOX with dual response of pH/ultrasound (US) irradiation, and to verify its efficacy in sonodynamic ...
ZOU Weijuan +5 more
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