Results 31 to 40 of about 432,621 (308)
International Journal of Nanomedicine, 2022 Meng Si,1,* Yanni Xia,1,* Menglin Cong,1,* Dandan Wang,2 Yong Hou,1 Hecheng Ma1 1Department of Orthopedic Surgery, Qilu Hospital of Shandong University, Jinan, 250012, People’s Republic of China; 2Jinan Center hospital affiliated to Shandong ...
Si M, Xia Y, Cong M, Wang D, Hou Y, Ma H
doaj
BMEMat, 2023 Chemodynamic therapy (CDT) utilizes Fenton and/or Fenton‐like reactions in the tumor microenvironment (TME) to produce cytotoxic reactive oxygen species (ROS, mainly hydroxyl radicals, •OH) for inducing cancer cell death.
Nan Yang +9 more
doaj +1 more source
Synergistic drug combinations from electronic health records and gene expression. [PDF]
, 2016 ObjectiveUsing electronic health records (EHRs) and biomolecular data, we sought to discover drug pairs with synergistic repurposing potential. EHRs provide real-world treatment and outcome patterns, while complementary biomolecular data, including ...
Chen, William +19 more
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Micromotor‐Enabled Active Hydrogen and Tobramycin Delivery for Synergistic Sepsis Therapy
Advanced Science, 2023 Sepsis is a highly heterogeneous syndrome normally characterized by bacterial infection and dysregulated systemic inflammatory response that leads to multiple organ failure and death.
Yanzhen Song +13 more
doaj +1 more source
Zein-Based Nanomedicines for Synergistic Chemodynamic/Photodynamic Therapy
ACS Omega, 2022 Current cancer treatment is not only limited to monotherapy but is also influenced by limited drug delivery options. Combined chemokinetic-photokinetic therapy has great promise in enhancing anticancer effects. Meanwhile, zein has superior self-assembly properties and can be loaded with photosensitizers.
Xiang Li +7 more
openaire +2 more sources
Functional genomics identifies new synergistic therapies for retinoblastoma [PDF]
Oncogene, 2020 AbstractLocal intravitreal or intra-arterial chemotherapy has improved therapeutic success for the pediatric cancer retinoblastoma (RB), but toxicity remains a major caveat. RB initiates primarily withRB1loss or, rarely,MYCNamplification, but the critical downstream networks are incompletely understood.
Arthur Aubry +13 more
openaire +2 more sources
Combinations of isoform-targeted histone deacetylase inhibitors and bryostatin analogues display remarkable potency to activate latent HIV without global T-cell activation [PDF]
, 2017 Current antiretroviral therapy (ART) for HIV/AIDS slows disease progression by reducing viral loads and increasing CD4 counts. Yet ART is not curative due to the persistence of CD4+ T-cell proviral reservoirs that chronically resupply active virus ...
Albert, Brice J +8 more
core +2 more sources
In vivo synergistic tumor therapies based on copper sulfide photothermal therapeutic nanoplatforms
Exploration, 2023 Tumor cells may be eliminated by increasing their temperature. This is achieved via photothermal therapy (PTT) by penetrating the tumor tissue with near‐infrared light and converting light energy into heat using photothermal agents.
Jingwen Ma +5 more
doaj +1 more source
BiologyDiabetic encephalopathy affects over 40% of diabetic patients globally, yet effective treatments remain critically limited. This study investigated the synergistic neuroprotective potential of alpha-lipoic acid (ALA) and metformin through the coordinated
Abdulmajeed F. Alrefaei +1 more
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PI3K/AKT/mTOR inhibition in combination with doxorubicin is an effective therapy for leiomyosarcoma. [PDF]
, 2016 BackgroundLeiomyosarcoma (LMS) is a common type of soft tissue sarcoma that responds poorly to standard chemotherapy. Thus the goal of this study was to identify novel selective therapies that may be effective in leiomyosarcoma by screening cell lines ...
Al-Awar, Rima +11 more
core +2 more sources