Results 11 to 20 of about 17,265 (196)

PKM2 inhibition may reverse therapeutic resistance to transarterial chemoembolization in hepatocellular carcinoma [PDF]

Journal of Experimental & Clinical Cancer Research, 2020
Abstract Background Therapeutic options for patients with hepatocellular carcinoma (HCC) are limited. Transarterial chemoembolization (TACE) is an interventional procedure used to deliver chemotherapy and embolizing agents directly to the tumor and is the procedure of choice for patients with intermediate stage HCC.
Sean P. Martin, Valerie Fako, Hien Dang, Dana A. Dominguez, Subreen Khatib, Lichun Ma, Haiyang Wang, Wei Zheng, Xin Wei Wang   +8 more
openaire   +3 more sources

c‐Rel–dependent Chk2 signaling regulates the DNA damage response limiting hepatocarcinogenesis

Hepatology, EarlyView., 2022
In response to genotoxic injury, c‐Rel upregulates ATM‐Chk2‐p53 pathway DNA damage proteins to limiting hepatocarcinogenesis. Abstract Background and Aims Hepatocellular carcinoma (HCC) is a leading cause of cancer‐related death. The NF‐κB transcription factor family subunit c‐Rel is typically protumorigenic; however, it has recently been reported as a
Jack Leslie, Jill E. Hunter, Amy Collins, Amelia Rushton, Lauren G. Russell, Erik Ramon‐Gil, Maja Laszczewska, Misti McCain, Marco Y. W. Zaki, Amber Knox, Yixin Seow, Laura Sabater, Daniel Geh, Neil D. Perkins, Helen L. Reeves, Dina Tiniakos, Derek A. Mann, Fiona Oakley   +17 more
wiley   +1 more source

Enhanced radiofrequency ablation for recurrent hepatocellular carcinoma post-transarterial chemoembolization: a prospective study utilizing twin internally cooled-perfusion electrodes [PDF]

Journal of Liver Cancer
Backgrounds/Aims Radiofrequency ablation (RFA) is widely employed for managing recurrent hepatocellular carcinoma (HCC) following transarterial chemoembolization (TACE).
Sungjun Hwang, Jae Hyun Kim, Sae-Jin Park, Su Jong Yu, Yoon Jun Kim, Jung-Hwan Yoon, Jeong Min Lee   +6 more
doaj   +1 more source

Therapeutic effect of postoperative adjuvant transcatheter arterial chemoembolization based on the neutrophil-to-lymphocyte ratio

Frontiers in Surgery, 2023
AimTo evaluate the feasibility of the preoperative neutrophil-to-lymphocyte ratio (NLR) as an index to guide postoperative adjuvant transcatheter arterial chemoembolization (PA-TACE) in patients with liver cancer.MethodsWe recruited a total of 166 patients with liver cancer who underwent surgery alone or surgery plus PA-TACE between January 2013 and ...
Guo-Ying Feng, Guo-Ying Feng, Zheng-Rong Shi, Yu-Fei Zhao, Kai Chen, Jie Tao, Xu-Fu Wei, Yu Cheng   +7 more
openaire   +3 more sources

Role of transarterial chemoembolization for hepatocellular carcinoma with extrahepatic metastases in the era of advancing systemic therapy [PDF]

Journal of Liver Cancer
Backgrounds/Aims Systemic therapy is the current standard treatment for hepatocellular carcinoma (HCC) with extrahepatic metastasis (EHM). However, some patients with HCC and EHM undergo transarterial chemoembolization (TACE) to manage intrahepatic ...
Byeong Geun Song, Myung Ji Goh, Wonseok Kang, Dong Hyun Sinn, Geum-Youn Gwak, Yong-Han Paik, Joon Hyeok Lee, Moon Seok Choi   +7 more
doaj   +1 more source

Diffusion Kurtosis Imaging for Assessing the Therapeutic Response of Transcatheter Arterial Chemoembolization in Hepatocellular Carcinoma [PDF]

Journal of Cancer, 2020
Objective: This study aimed to evaluate the therapeutic response of hepatocellular carcinoma (HCC) after transcatheter arterial chemoembolization (TACE) with diffusion kurtosis imaging (DKI). Methods: Forty-three patients with fifty-nine hepatic cancer nodules were recruited for this study. All patients were treated by TACE. Magnetic resonance imaging (
Yuan, Zhen-Guo, Wang, Zong-Ying, Xia, Meng-Ying, Li, Feng-Zhi, Li, Yao, Shen, Zhen, Wang, Xi-Zhen   +6 more
openaire   +2 more sources

Impact of Hyperglycemia on Complication and Mortality after Transarterial Chemoembolization for Hepatocellular Carcinoma [PDF]

Diabetes & Metabolism Journal
Background Current guidelines regarding periprocedural glycemic control to prevent complications after nonsurgical invasive procedures are insufficient.
Sun Joon Moon, Chang Ho Ahn, Yun Bin Lee, Young Min Cho   +3 more
doaj   +1 more source

Idarubicin‐Loaded DEB‐TACE plus Lenvatinib versus Lenvatinib for patients with advanced hepatocellular carcinoma: A propensity score‐matching analysis

Cancer Medicine, 2023
Aims To investigate the efficacy and safety of lenvatinib and idarubicin‐loaded drug‐eluting beads transarterial chemoembolization (IDADEB‐TACE) in primary advanced hepatocellular carcinoma (HCC).
Wenzhe Fan, Bowen Zhu, Shufan Yue, Xinlin Zheng, Xinhua Zou, Fuliang Li, Liangliang Qiao, Yanqin Wu, Miao Xue, Hongyu Wang, Yiyang Tang, Jiaping Li   +11 more
doaj   +1 more source

Advanced imaging techniques in the therapeutic response of transarterial chemoembolization for hepatocellular carcinoma

World Journal of Gastroenterology, 2016
Hepatocellular carcinoma (HCC) is one of the major causes of morbidity and mortality in patients with chronic liver disease. Transarterial chemoembolization (TACE) can significantly improve the survival rate of patients with HCC and is the first treatment choice for patients who are not suitable for surgical resections.
Ke, Yang, Xiao-Ming, Zhang, Lin, Yang, Hao, Xu, Juan, Peng   +4 more
openaire   +2 more sources

Preliminary outcomes of DEB-TACE loaded with raltitrexed in the treatment of unresectable or recurrent hepatocellular carcinoma

Cancer Imaging, 2023
Purpose Raltitrexed shows therapeutic effects and safety in many types of malignant tumors. However, reports of the clinical outcomes of raltitrexed-based transarterial chemoembolization (TACE) or drug-eluting beads TACE (DEB-TACE) in the treatment of ...
Yonghua Bi, Yang Wang, Wenguang Zhang, Huibin Lu, Jianzhuang Ren, Xinwei Han   +5 more
doaj   +1 more source