Results 51 to 60 of about 41,400 (225)

Glutamine Deprivation Triggers Tribbles Homolog 3 Dependent G‐Quadruplex Resolution to Maintain DNA Repair and Tumor Survival

Advanced Science, EarlyView.
Glutamine deprivation triggers transient DNA damage yet activates adaptive repair in hepatocellular carcinoma cells. We identify TRIB3 as a stress‐induced nuclear scaffold that associates with DDX5 and G‐quadruplex DNA atBRCA1 andRAD51AP1 promoters. TRIB3 loss increases G4 accumulation, suppresses HR gene transcription, elevates γ‐H2A.X, and sensitizes
Qiang Ji, Xuedan Sun, Zhangran Sun, Mengfan Li, Xinyu Cheng, Shuai Tian, Rick F. Thorne, Jinming Li, Guangzhi Liu, Mian Wu, Xiaoying Liu   +10 more
wiley   +1 more source

Biodegradable ion-exchange microspheres based on modified polylysines [PDF]

, 1995
Poly-L-lysine was synthesized via a triethylamine initiated ring-opening polymerization of Z-L-lysine-N'~-carboxyanhydride,\ud followed by deprotection of the E-amino group. Subsequently the polylysine was sulfamated using a pyridinium-sulfate complex to
Cremers, H.F.M., Feijen, J., Lens, J.P., Seymour, L.   +3 more
core   +6 more sources

Hepatocellular carcinoma and multidrug resistance: Past, present and new challenges for therapy improvement [PDF]

, 2015
Hepatocellular carcinoma (HCC) is the most common malignancy of the liver and the third cause of cancer death worldwide. Chronic hepatitis due to HBV and HCV infection are two major risk factors for HCC worldwide.
Cuestas, María Luján, Mathet, Veronica Lidia, Oubiña, Jose Raul   +2 more
core   +1 more source

Novel Vascular‐Adaptive Liquid Metal Microspheres Enable Visualized Arterial Embolization Therapy

Advanced Science, EarlyView.
We present drug‐loaded liquid metal microspheres (X‐MEN) as a novel agent for image‐guided arterial embolization. With inherent radiopacity and superior deformability, X‐MEN enables real‐time monitoring and conforms tightly to irregular vessels. This approach ensures precise, long‐lasting embolization without recanalization, addressing critical ...
Chenyu Shen, Junge Chen, Gang Zhang, Zhusheng Liu, Yichen Wan, Lei Lei, Weiyan Ren, Yanyu Zhao, Bozhang Xia, Zhiqiang Yi, Jinjin Wang, Jingwang Gao, Gen Mu, Xing‐Jie Liang, Zhijun Wang   +14 more
wiley   +1 more source

Critical Points for the Production of Polymeric Microspheres Used in X-Ray Surgery

Разработка и регистрация лекарственных средств, 2020
Introduction. Saturated polymer microspheres represent one of the leading developments in the field of chemoembolization. Due to the complicated multi-stage production in the Russian market, mainly foreign manufacturers of these products are represented,
T. A. Bitkina, A. V. Basevich, V. M. Rodin   +2 more
doaj   +1 more source

Evaluation of Hepatocellular Carcinoma Transarterial Chemoembolization using Quantitative Analysis of 2D and 3D Real-time Contrast Enhanced Ultrasound. [PDF]

, 2018
Quantitative 2D and 3D contrast-enhanced ultrasound (CEUS) was assessed to evaluate early transarterial chemoembolization (TACE) treatment response. Seventeen patients scheduled for TACE for the treatment of hepatocellular carcinoma participated in the ...
Eisenbrey, John R., Forsberg, Flemming, Kono, Yuko, Lyshchik, Andrej, Machado, Priscilla, Nam, Kibo, Shaw, Colette M., Stanczak, Maria   +7 more
core   +1 more source

Embolization in an adrenocortical carcinoma as palliative therapy [PDF]

, 1999
Background: With an annual incidence of 0.2% of new cases per 100,000 inhabitants, adrenocortical carcinoma is rare. In advanced tumor only palliative treatment modalities are practicable. Because of scarcity of the tumor, standard treatment has not been
Braunschweig, R., Forstpointner, Roswitha, Kühl, M., Lang, N., Meissner, H., Schalhorn, Andreas   +5 more
core   +1 more source

Association of HAMP Expression and CD8+ T‐Cell Infiltration With Atezolizumab–Bevacizumab Response in Hepatocellular Carcinoma

Annals of Gastroenterological Surgery, EarlyView.
In hepatocellular carcinoma treated with atezolizumab–bevacizumab, responders showed RNA‐seq enrichment of immune and chemokine pathways with higher HAMP expression. In resected specimens, immunohistochemistry confirmed increased intratumoral CD8+ T‐cell density and hepcidin (HAMP), supporting HAMP plus CD8 as components of a composite predictor of ...
Shun Nakamura, Yuki Murakami, Yusuke Oshima, Takashi Masuda, Wataru Miyoshino, Hiroomi Takayama, Yoko Kawano, Teijiro Hirashita, Yuichi Endo, Masafumi Inomata   +9 more
wiley   +1 more source

COMPLICATIONS OF NEOADYAVANT THERAPY FOR CANCER OF THE HEAD OF THE PANCREAS

Сибирский онкологический журнал, 2019
Aim: to study complications of preoperative chemoembolization of the gastroduodenal artery and external beam radiation therapy in patients with pancreatic head cancer.Material and Methods.
R. I. Rasulov, M. V. Zemko, A. V. Shelekhov, K. G. Zubrinckiy, G. I. Songolov   +4 more
doaj   +1 more source

Multimodality Treatment with Conventional Transcatheter Arterial Chemoembolization and Radiofrequency Ablation for Unresectable Hepatocellular Carcinoma [PDF]

, 2012
Background/Aims: To evaluate the efficacy of multimodality treatment consisting of conventional transcatheter arterial chemoembolization (TACE) and radiofrequency ablation (RFA) in patients with non-resectable and non-ablatable hepatocellular carcinoma ...
Albrecht T, Bloomston M, Bosch FX, Bruix J, Bruix J, Buscarini E, Buscarini L, Buscarini L, C. Trumm, Camma C, Clasen S, Dupuy DE, El-Serag HB, F. Bamberg, F.T. Kolligs, Geschwind JF, Jemal A, Kagawa T, Kettenbach J, Kim JH, Kirikoshi H, Lencioni R, Lencioni R, Lencioni R, Lencioni RA, Lin SM, Lin SM, Livraghi T, Livraghi T, Llovet JM, Llovet JM, Lo CM, M. Rentsch, M.F. Reiser, Marelli L, Marrero JA, N. Ashoori, Oken MM, P. Paprottka, Parkin DM, Poon RT, Rossi S, Sherman M, Shiina S, T.F. Jakobs, Veltri A, Vetter D, Yamakado K, Zhang L   +48 more
core   +1 more source