Results 301 to 310 of about 498,931 (351)

Targeting chemokines and chemokine receptors with antibodies

Drug Discovery Today: Technologies, 2012
Chemokines and their receptors are highly interesting therapeutic targets for pharmaceutical and biotechnology companies. In particular, industrial development pipelines are filled with new chemokine-targeting drugs to treat inflammatory diseases and malignancies.
Klarenbeek, A., Maussang, D., Blanchetot, C., Saunders, M., van der Woning, S.P., Smit, M.J., Haard, H., Hofman, E.   +7 more
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Chemokine receptors

Cytokine & Growth Factor Reviews, 2001
Although chemokines were originally defined as host defense proteins it is now clear that their repertoire of functions extend well beyond this role. For example chemokines such as MGSA have growth regulatory properties while members of the CXC chemokine family can be mediators or inhibitors of angiogenesis and may be important targets for oncology ...
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Chemokines and chemokine receptors in renal pathology

Current Opinion in Nephrology and Hypertension, 2003
Chemokines are members of the largest group of chemotactic cytokines, and were the first shown to be able to engage specific subpopulations of inflammatory cells. Accordingly, our expanding knowledge in chemokine biology has enlarged our understanding of inflammatory cell interactions, lymphopoesis, specificity of cell recruitment, and a variety of ...
Stephan, Segerer, Charles E, Alpers
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Chemokines and Chemokine Receptors

2001
The recruitment of cells to sites of inflammation is an essential component of the host inflammatory response. Cell recruitment relies on the coordinated action of cell activation, cell adhesion, chemoattraction, and transmigration across the endothelial barrier.
Andrew D. Luster, James MacLean
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Pathological roles of the homeostatic chemokine CXCL12.

Cytokine & growth factor reviews, 2018
CXCL12 is a CXC chemokine that traditionally has been classified as a homeostatic chemokine. It contributes to physiological processes such as embryogenesis, hematopoiesis and angiogenesis. In contrast to these homeostatic functions, increased expression
R. Janssens, S. Struyf, P. Proost
semanticscholar   +1 more source

Introduction to Chemokines and Chemokine Antagonists

2004
Chemokines are small, soluble proteins with four conserved cysteines (Baggiolini et al. 1994, 1997). They consist of about 70–130 amino acids yielding molecular weights in the range of 7–15 kDa, and are synthesized with a leader sequence of 20–25 amino acids, which is cleaved off before release.
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Chemokines and Chemokine Receptors Encoded by Cytomegaloviruses

2008
CMVs carry several genes that are homologous to genes of the host organism. These include genes homologous to those encoding chemokines (CKs) and G protein-coupled receptors (GPCRs). It is generally assumed that these CMV genes were hijacked from the host genome during the long co-evolution of virus and host.
Beisser, PS, Lavreysen, H, Bruggeman, CA, Vink, Kees   +3 more
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Chemokines and chemokine receptors in infectious diseases

Immunology & Cell Biology, 1999
Today, 10 years after the discovery of IL‐8, chemokines (chemotactic cytokines) are seen as the stimuli that largely control leucocyte migration. Chemokines are low molecular weight chemoattractant cytokines secreted by a variety of cells, including leucocytes, epithelial cells, endothelial cells, fibroblasts and numerous other cell types.
S, Mahalingam, G, Karupiah
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Chemokines and chemokine receptors

2009
There is a structural and a functional classification of chemokines. The former includes four groups: CXC, CC, C and CX3C chemokines. There is a redundancy and binding promiscuity between chemokine receptors and their ligands. Recently, a functional classification distinguishing between inflammatory and homeostatic chemokines has been introduced ...
Zoltán Szekanecz, Alisa E. Koch
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Chemokine sequestration by atypical chemokine receptors

Biochemical Society Transactions, 2006
Leucocyte migration is essential for robust immune and inflammatory responses, and plays a critical role in many human diseases. Chemokines, a family of small secreted protein chemoattractants, are of fundamental importance in this process, directing leucocyte trafficking by signalling through heptahelical G-protein-coupled receptors expressed by the ...
C A H, Hansell, C V, Simpson, R J B, Nibbs   +2 more
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