Results 261 to 270 of about 63,435 (292)
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The inflammatory chemokines CCL2 and CCL5 in breast cancer
Cancer Letters, 2008A causal role was recently attributed to inflammation in many malignant diseases, including breast cancer. The different inflammatory mediators that are involved in this disease include cells, cytokines and chemokines. Of these, many studies have addressed the involvement and roles of the inflammatory chemokines CCL2 (MCP-1) and CCL5 (RANTES) in breast
Gali, Soria, Adit, Ben-Baruch
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Increase of CXC chemokine CXCL10 and CC chemokine CCL2 serum levels in normal ageing
Cytokine, 2006No study has evaluated contemporaneously serum CXC and CC chemokines changes in normal ageing. Serum levels of CXCL10 (sCXCL10) (CXC) and CCL2 (sCCL2) (CC) prototype chemokines have been measured in 164 healthy subjects, from 10 to 79 years of age (82 males/82 females).
Alessandro Antonelli +2 more
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Dissecting the differential structural and dynamics features of CCL2 chemokine orthologs
International Journal of Biological Macromolecules, 2020Chemokines are a sub-group of cytokines that regulate the leukocyte migration. Monocyte chemoattractant protein-1 (MCP/CCL2) is one of the essential CC chemokine that regulates the migration of monocytes into inflamed tissues. It has been observed that the primary sequences of CCL2 orthologs among rodents and primates vary significantly at the C ...
Nidhi, Joshi +6 more
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Chemokine CCL2 Induces Apoptosis in Cortex Following Traumatic Brain Injury
Journal of Molecular Neuroscience, 2013The chemokine C-C motif ligand 2 (CCL2) is an important mediator of neuroinflammation. Released in response to acute injury, ischemia, and neurodegenerative disease, CCL2 binds primarily to the G-protein-coupled chemokine C-C motif receptor 2 (CCR2) to recruit inflammatory cells to sites of tissue damage. Inflammation is thought to have both beneficial
Su Liu, Lixia Zhang, Qinfeng Wu
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2021
Curcumin, as a vegetative flavonoid, has a protective and therapeutic role in various adverse states such as oxidative stress and inflammation. Remedial properties of this component have been reported in the different chronic diseases including cancers (myeloma, pancreatic, breast, colorectal), vitiligo, psoriasis, neuropathic pains, inflammatory ...
Mahdiyeh, Hedayati-Moghadam +7 more
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Curcumin, as a vegetative flavonoid, has a protective and therapeutic role in various adverse states such as oxidative stress and inflammation. Remedial properties of this component have been reported in the different chronic diseases including cancers (myeloma, pancreatic, breast, colorectal), vitiligo, psoriasis, neuropathic pains, inflammatory ...
Mahdiyeh, Hedayati-Moghadam +7 more
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Serum α-Chemokine CXCL10 and β-Chemokine CCL2 Levels in HCV-Positive Cryoglobulinemia
2011Chemokines are a group of low-molecular-weight peptides that induce the recruitment of leukocytes to sites of inflammation. Among the four major families, CXC chemokines, with CXCL10 as the prototype, display a strong chemo-attractant activity for Th1 lymphocytes and is a reliable marker of Th1-immune mediated diseases.
ANTONELLI, ALESSANDRO +7 more
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Experimental and Molecular Pathology, 2015 Chemokines are important secondary inflammatory mediators released in response to stimuli which act as second-order cytokines with specialized functions in inflammation. The role of many of these specialized mediators is as yet poorly understood in the human intervertebral disc.
Helen E Gruber +2 more
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Role of chemokine CCL2 and its receptor CCR2 in neurodegenerative diseases
Archives of Pharmacal Research, 2013Chemokines are members of the chemoattractant cytokine family. They play key roles in the trafficking of leukocytes and in the induction of chemotaxis through the activation of G protein-coupled receptor. Considerable interest has been paid to these molecules to elucidate their roles in the unique inflammatory responses elicited in the central nervous ...
Shambhunath, Bose, Jungsook, Cho
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European Journal of Neurology, 2001
Studies of chemokines in cerebrospinal fluid (CSF) of patients with active multiple sclerosis (MS) have indicated that specific chemokines may have important roles in disease pathogenesis. We previously reported that CSF concentrations of CXCL10 (previously known as IP‐10) were elevated in MS patients in relapse, whilst levels of CCL2 (MCP‐1) were ...
Sørensen, Torben Lykke +4 more
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Studies of chemokines in cerebrospinal fluid (CSF) of patients with active multiple sclerosis (MS) have indicated that specific chemokines may have important roles in disease pathogenesis. We previously reported that CSF concentrations of CXCL10 (previously known as IP‐10) were elevated in MS patients in relapse, whilst levels of CCL2 (MCP‐1) were ...
Sørensen, Torben Lykke +4 more
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Identification of CCR2‐binding features in Cytl1 by a CCL2‐like chemokine model
Proteins: Structure, Function, and Bioinformatics, 2011AbstractChemokines are small secreted proteins that play an important role in immune responses and have also been shown to be involved in cartilage development and contributing to pathogenesis of a variety of diseases. They present a conserved 3D structure, so‐called IL8‐like chemokine fold, which is supported by conserved cysteines forming intra ...
Aurelie, Tomczak, M Teresa, Pisabarro
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