Results 301 to 310 of about 87,127 (319)

Chemokine CCL2 and chemokine receptor CCR2 in early active multiple sclerosis

European Journal of Neurology, 2004
The chemokine monocyte chemoattractant protein (MCP)‐1/CCL2 and its receptor CCR2 have been strongly implicated in disease pathogenesis in experimental autoimmune encephalomyelitis, an animal model of multiple sclerosis (MS), whereas data on the CCL2–CCR2 axis are scarce in MS.
Sørensen, Torben Lykke, Ransohoff, R M, Strieter, R M, Sellebjerg, F   +3 more
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The inflammatory chemokines CCL2 and CCL5 in breast cancer

Cancer Letters, 2008
A causal role was recently attributed to inflammation in many malignant diseases, including breast cancer. The different inflammatory mediators that are involved in this disease include cells, cytokines and chemokines. Of these, many studies have addressed the involvement and roles of the inflammatory chemokines CCL2 (MCP-1) and CCL5 (RANTES) in breast
Gali, Soria, Adit, Ben-Baruch
openaire   +2 more sources

Increase of CXC chemokine CXCL10 and CC chemokine CCL2 serum levels in normal ageing

Cytokine, 2006
No study has evaluated contemporaneously serum CXC and CC chemokines changes in normal ageing. Serum levels of CXCL10 (sCXCL10) (CXC) and CCL2 (sCCL2) (CC) prototype chemokines have been measured in 164 healthy subjects, from 10 to 79 years of age (82 males/82 females).
ANTONELLI, ALESSANDRO, Rotondi M, Fallahi P, Ferrari SM, PAOLICCHI, ALDO, Romagnani P, Serio M, FERRANNINI, ELEUTERIO   +7 more
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Serum α-Chemokine CXCL10 and β-Chemokine CCL2 Levels in HCV-Positive Cryoglobulinemia

2011
Chemokines are a group of low-molecular-weight peptides that induce the recruitment of leukocytes to sites of inflammation. Among the four major families, CXC chemokines, with CXCL10 as the prototype, display a strong chemo-attractant activity for Th1 lymphocytes and is a reliable marker of Th1-immune mediated diseases.
ANTONELLI, ALESSANDRO, Ferri C, Ferrari SM, Colaci M, Ruffilli I, Mancusi C, FERRANNINI, ELEUTERIO, Fallahi P.   +7 more
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Chemokine CCL2 Induces Apoptosis in Cortex Following Traumatic Brain Injury

Journal of Molecular Neuroscience, 2013
The chemokine C-C motif ligand 2 (CCL2) is an important mediator of neuroinflammation. Released in response to acute injury, ischemia, and neurodegenerative disease, CCL2 binds primarily to the G-protein-coupled chemokine C-C motif receptor 2 (CCR2) to recruit inflammatory cells to sites of tissue damage. Inflammation is thought to have both beneficial
Su, Liu, Lixia, Zhang, Qinfeng, Wu, Qi, Wu, Tong, Wang   +4 more
openaire   +2 more sources

Dissecting the differential structural and dynamics features of CCL2 chemokine orthologs

International Journal of Biological Macromolecules, 2020
Chemokines are a sub-group of cytokines that regulate the leukocyte migration. Monocyte chemoattractant protein-1 (MCP/CCL2) is one of the essential CC chemokine that regulates the migration of monocytes into inflamed tissues. It has been observed that the primary sequences of CCL2 orthologs among rodents and primates vary significantly at the C ...
Nidhi, Joshi, Nupur, Nagar, Khushboo, Gulati, Krishnakant, Gangele, Amit, Mishra, Dinesh, Kumar, Krishna Mohan, Poluri   +6 more
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Role of chemokine CCL2 and its receptor CCR2 in neurodegenerative diseases

Archives of Pharmacal Research, 2013
Chemokines are members of the chemoattractant cytokine family. They play key roles in the trafficking of leukocytes and in the induction of chemotaxis through the activation of G protein-coupled receptor. Considerable interest has been paid to these molecules to elucidate their roles in the unique inflammatory responses elicited in the central nervous ...
Shambhunath, Bose, Jungsook, Cho
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Chemokines CXCL10 and CCL2: differential involvement in intrathecal inflammation in multiple sclerosis

European Journal of Neurology, 2001
Studies of chemokines in cerebrospinal fluid (CSF) of patients with active multiple sclerosis (MS) have indicated that specific chemokines may have important roles in disease pathogenesis. We previously reported that CSF concentrations of CXCL10 (previously known as IP‐10) were elevated in MS patients in relapse, whilst levels of CCL2 (MCP‐1) were ...
Sørensen, Torben Lykke, Sellebjerg, F, Jensen, C V, Strieter, R M, Ransohoff, R M   +4 more
openaire   +2 more sources

[CCL2 chemokine and transmission of nociceptive information].

Biologie aujourd'hui, 2011
Chemokines are small proteins belonging to the family of inflammatory cytokines whose main property is to attract and activate immune cells. Chemokines produce their biological activity by interacting with receptors belonging to the family of G protein-coupled receptors (GPCR).
openaire   +1 more source