Results 171 to 180 of about 369,183 (362)

Lymphoid and CXCR4 Cell Targeted Lipid Nanoparticles Facilitate HIV‐1 Proviral DNA Excision

Advanced Healthcare Materials, EarlyView.
Advancements in ART improve HIV‐1 patient outcomes but are unable to eliminate latent viral DNA. To address this, CXCR4‐targeted lipid nanoparticles (T‐LNPs) for delivering CRISPR‐Cas9 to excise HIV‐1 DNA in infected cells are developed. These T‐LNPs achieve ≈60% HIV‐1 DNA excision efficacy in blood and splenic tissue, demonstrating promise for ...
Sudipta Panja, Lubaba A. Zaman, Chen Zhang, Milankumar Patel, Santhi Gorantla, Prasanta K. Dash, Howard E. Gendelman   +6 more
wiley   +1 more source

A Broad Range of Chemokine Receptors Are Used by Primary Isolates of Human Immunodeficiency Virus Type 2 as Coreceptors with CD4

, 1998
Àine McKnight, Matthias T. Dittmar, José Moniz-Periera, Koya Ariyoshi, Jacqueline D. Reeves, Sam Hibbitts, Denise Whitby, Emma Aarons, Amanda E. I. Proudfoot, Hilton Whittle, Paul R. Clapham   +10 more
openalex   +1 more source

The B-Oligomer of Pertussis Toxin Deactivates Cc Chemokine Receptor 5 and Blocks Entry of M-Tropic HIV-1 Strains [PDF]

, 1999
Massimo Alfano, Helena Schmidtmayerova, C. A. Amella, Tatiana Pushkarsky, Michael Bukrinsky   +4 more
openalex   +1 more source

Molecular Mechanisms of Extracellular Vesicle Biogenesis and Their Impact on the Design of Custom EVs

Advanced Healthcare Materials, EarlyView.
Extracellular vesicles (EVs) are pivotal mediators of intercellular communication and disease, yet the fundamental mechanisms controlling their biogenesis and cargo selection remain unclear. This limitation hinders their diagnostic utility and therapeutic development.
Luís Carvalho Ferraz, Paulo Pereira, João Vasco Ferreira   +2 more
wiley   +1 more source

Cutting Edge: Immature Dendritic Cells Generated from Monocytes in the Presence of TGF-β1 Express Functional C-C Chemokine Receptor 6 [PDF]

, 1999
De Yang, O. M. Zack Howard, Qian Chen, Joost J. Oppenheim   +3 more
openalex   +1 more source

An Organ‐on‐Chip Platform for Strain‐Controlled, Tissue‐Specific Compression of Cartilage and Mineralized Osteochondral Interface to Study Mechanical Overloading in Osteoarthritis

Advanced Healthcare Materials, EarlyView.
A mechanically active OsteoChondral Unit (OCU)‐on‐Chip platform mimicking the OCU's functional anatomy and the strain gradient across the osteochondral interface is presented. Upon compartment‐specific hyperphysiological compression, the model replicates mechanisms observed in osteoarthritis (OA) progression, such as calcium crystal accumulation ...
Andrea Mainardi, Anastasiya Börsch, Paola Occhetta, Robert Ivanek, Martin Ehrbar, Lisa Krattiger, Philipp Oertle, Marko Loparic, Ivan Martin, Marco Rasponi, Andrea Barbero   +10 more
wiley   +1 more source

The Equine Herpesvirus 2 E1 Open Reading Frame Encodes a Functional Chemokine Receptor

, 1999
Grazia Camarda, Gaia Spinetti, Giovanni Bernardini, Catherine Mair, Nicholas Davis‐Poynter, Maurizio C. Capogrossi, Monica Napolitano   +6 more
openalex   +1 more source

A Novel Mutation in the Coding Sequence of the FY*B Allele of the Duffy Chemokine Receptor Gene Is Associated With an Altered Erythrocyte Phenotype [PDF]

, 1998
Niva Parasol, Marion E. Reid, María Rios, Lilian Castilho, Ilana Harari, Nechama S. Kosower   +5 more
openalex   +1 more source

Practical Guide to the Design of Granular Hydrogels for Customizing Complex Cellular Microenvironments

Advanced Healthcare Materials, EarlyView.
Granular hydrogels are emerging microporous platforms for cell culture and delivery, showing great potential for replicating the complex, heterogeneous environments found in natural tissues. This review outlines the design principles of granular hydrogels, highlighting critical factors that determine the final physicochemical properties of the entire ...
Shuhan Feng, Kaiyang Chen, Shiqi Wang
wiley   +1 more source

Chemokine and chemokine receptor expression after combined anti-HIV-1 interleukin-2 therapy

, 1999
Julià Blanco, Cecilia Cabrera, Antoni Jou, Lidia Ruíz, Bonaventura Clotet, José A. Esté   +5 more
openalex   +1 more source