Results 181 to 190 of about 375,096 (307)

Gut Lactate Boosts Ruminococcus via Histone Lactylation to Mediate Time‐Restricted Feeding Protection in Crohn's Disease

Advanced Science, EarlyView.
TRF enriches Ruminococcus, a bacterial genus producing SCFAs, and activates the epithelial HIF‐1α signaling pathway. This mechanism protects the colonic mucosa from inflammatory insults in colitis models. Mechanistically, gut lactate production during starvation and refeeding mediates H4K12la, which increases SLC9A3 expression and creates an acidic gut
Linwen Huang, Huishi Tan, Senhui Weng, Yuntao Liu, Lingxu Song, Shaoyu Cheng, Zelong Lin, Jiawei Chen, Fei Tan, Jun Wang, Jinke Huang, Linkun Cai, Jiwei Chai, Cailing Zhong, Yanqiang Shi, Wendi Zhang, Haiyan Zhang, Chongyang Huang   +17 more
wiley   +1 more source

Surface Plasmon Resonance as a Potential Diagnostic Tool for the Detection of CXC Chemokine Receptor 4 (CXCR4) on Extracellular Vesicles. [PDF]

Biosensors (Basel)
Verleye K, Noppen S, Boonen A, Yildizhan Y, Van Loy T, Heens C, Vanderhoydonc F, Pinheiro C, Lins PMP, Bronckaers A, Hendrix A, Swinnen JV, Spasic D, Lammertyn J, Pannecouque C, Schols D.   +15 more
europepmc   +1 more source

The AUTACE That Degrades KRAS and Engages CD8+ T Cells for the Treatment of KRAS/TP53 Co‐Mutant Tumors

Advanced Science, EarlyView.
AUTACE is a bifunctional nanoplatform that integrates tumor targeting, immune engagement, and on‐demand KRAS degradation. It targets KRAS/TP53 co‐mutant tumors via TP53‐specific TCRs, elicits antitumor CD8+ T‐cell responses through surface anti‐CD3 antibodies, and uses low‐intensity focused ultrasound (LIFU) to trigger controlled release of the KRAS ...
Luo Li, Bolin Li, Yanan Hao, Bo Pang, Pan Li, Chunli Li, Yu Tang   +6 more
wiley   +1 more source

Establishing C-X-C motif chemokine receptor 4 as a novel imaging target in giant cell arteritis. [PDF]

Arthritis Res Ther
Fröhlich M, Serfling SE, Gernert M, Guggenberger K, Higuchi T, Gerhard-Hartmann E, Weich A, Samnick S, Schmalzing M, Bley TA, Buck AK, Werner RA.   +11 more
europepmc   +1 more source

Combination Immunotherapy as a Promising Strategy to Overcome Immunotherapy Resistance: From Emergence to Next‐Generation Approaches

Advanced Science, EarlyView.
This review examines emerging combination immunotherapy strategies tailored to distinct tumor microenvironments and highlights next‐generation biomarkers that guide response prediction and treatment personalization. It integrates lessons from unsuccessful trials, addresses toxicity challenges, and outlines approaches for early biomarker discovery and ...
Asmita Pandey, Sudhir Kumar Rai, Li Ma, Lauren Higa, Vedbar Khadka, Hua Yang, Youping Deng   +6 more
wiley   +1 more source

β‑Arrestin-Mediated Activation of Chemokine Receptor CCR7 by Human β‑Defensin‑3 Drives Oral Squamous Cell Carcinoma Progression. [PDF]

JACS Au
Kinanti NP, Chang CC, Lai XY, Hsu HJ.
europepmc   +1 more source

Autoimmune Encephalitis in Acute Care—Pathology, Diagnosis, and Management

Advanced Science, EarlyView.
ABSTRACT Autoimmune encephalitis (AE) is characterized by immune‐mediated inflammation of the brain parenchyma, presenting with various neurological syndromes, including but not limited to seizures, altered consciousness, neuropsychiatric symptoms, and movement disorders.
Suneesh Thilak, David Okoh, William Scotton, Shanika Samarasekera, Vikram Patil, Suresh Renukappa, Andrew Macduff, Subashini Suresh, Rajeev Krishnadas, Tonny Veenith   +9 more
wiley   +1 more source

Effect of phosphorylation barcodes on arrestin binding to a chemokine receptor. [PDF]

Nature
Chen Q, Schafer CT, Mukherjee S, Wang K, Gustavsson M, Fuller JR, Tepper K, Lamme TD, Aydin Y, Agrawal P, Terashi G, Yao XQ, Kihara D, Kossiakoff AA, Handel TM, Tesmer JJG.   +15 more
europepmc   +1 more source

NUP85 Mediates Endoplasmic Reticulum Stress through the USP47/ASK1 Signaling Pathway to Regulate the Progression of Liver Fibrosis

Advanced Science, EarlyView.
In the present study, we have demonstrated that the NUP85‐USP47‐ASK1 signaling pathway may have regulated the progression of liver fibrosis through modulating ERS. Additionally, we have developed a CREKA‐coupled liposome to target delivery of MV, a pharmacological inhibitor of NUP85, to activated HSCs, thereby attenuating liver fibrosis. ABSTRACT Liver
Dashuai Yang, Haoran Yang, Linxin Pan, Chang Tian, Fucheng Zuo, Shilei Huang, Xianrui Li, Ming Chen, Cheng Qian, Jie Wang, Zhaolin Chen, Tao Xu   +11 more
wiley   +1 more source

Chemokine Receptor Profiles as Predictors of Survival and Early Progression in Follicular Lymphoma. [PDF]

EJHaem
Zupo A, Pansy K, Gaksch L, Waldhart J, Brunner A, Strobl J, Szmyra-Polomka M, Haingartner S, Tomazic PV, Greinix HT, Uhl B, Feichtinger J, Stary G, Haybaeck J, Vagena FR, Zacharias M, Beham-Schmid C, Neumeister P, Prochazka KT, Deutsch AJA.   +19 more
europepmc   +1 more source