Results 171 to 180 of about 5,720 (219)
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Chemokines, chemokine receptors and pain
Trends in Immunology, 2005Many patients suffer from neuropathic pain as a result of injury to the peripheral nervous system (e.g. post-herpetic neuralgia or diabetic neuropathy) or to the central nervous system (e.g. spinal cord injury or stroke). The most distinctive symptom of neuropathic pain is allodynia, whereby normally non-painful stimuli, such as light touch, become ...
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Chemokine sequestration by atypical chemokine receptors
Biochemical Society Transactions, 2006Leucocyte migration is essential for robust immune and inflammatory responses, and plays a critical role in many human diseases. Chemokines, a family of small secreted protein chemoattractants, are of fundamental importance in this process, directing leucocyte trafficking by signalling through heptahelical G-protein-coupled receptors expressed by the ...
C A H, Hansell +2 more
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Targeting chemokines and chemokine receptors with antibodies
Drug Discovery Today: Technologies, 2012Chemokines and their receptors are highly interesting therapeutic targets for pharmaceutical and biotechnology companies. In particular, industrial development pipelines are filled with new chemokine-targeting drugs to treat inflammatory diseases and malignancies.
Klarenbeek, A. +7 more
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Chemokines and chemokine receptors in renal pathology
Current Opinion in Nephrology and Hypertension, 2003Chemokines are members of the largest group of chemotactic cytokines, and were the first shown to be able to engage specific subpopulations of inflammatory cells. Accordingly, our expanding knowledge in chemokine biology has enlarged our understanding of inflammatory cell interactions, lymphopoesis, specificity of cell recruitment, and a variety of ...
Stephan, Segerer, Charles E, Alpers
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Chemokines and Chemokine Receptors Encoded by Cytomegaloviruses
2008CMVs carry several genes that are homologous to genes of the host organism. These include genes homologous to those encoding chemokines (CKs) and G protein-coupled receptors (GPCRs). It is generally assumed that these CMV genes were hijacked from the host genome during the long co-evolution of virus and host.
Beisser, PS +3 more
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Chemokines and Chemokine Receptors
1999Classic chemoattractants include complement components, formyl peptides and leukotriene B4. In addition, various cytokines are able to elicit directional migration of leukocytes. While molecules such as monocyte-colony stimulating factor or tumor necrosis factor also exert chemotactic activity, the main chemotactic cytokines are a superfamily of ...
A. Mantovani +6 more
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Chemokine Receptors and Chemokines in HIV Infection
Journal of Clinical Immunology, 1998Suppression of HIV by chemokines represents a special case in virology and immunology where soluble molecules other than antibodies inhibit infection by a specific virus. The basis for this inhibition is that HIV has evolved to use certain chemokine receptors as "coreceptors" for entry into host cells.
GARZINO DEMO, ALFREDO +2 more
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Chemokines and Chemokine Receptors
2001The recruitment of cells to sites of inflammation is an essential component of the host inflammatory response. Cell recruitment relies on the coordinated action of cell activation, cell adhesion, chemoattraction, and transmigration across the endothelial barrier.
Andrew D. Luster, James MacLean
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Chemokines and chemokine receptors in infectious diseases
Immunology & Cell Biology, 1999Today, 10 years after the discovery of IL‐8, chemokines (chemotactic cytokines) are seen as the stimuli that largely control leucocyte migration. Chemokines are low molecular weight chemoattractant cytokines secreted by a variety of cells, including leucocytes, epithelial cells, endothelial cells, fibroblasts and numerous other cell types.
S, Mahalingam, G, Karupiah
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Chemokines and chemokine receptors
2009There is a structural and a functional classification of chemokines. The former includes four groups: CXC, CC, C and CX3C chemokines. There is a redundancy and binding promiscuity between chemokine receptors and their ligands. Recently, a functional classification distinguishing between inflammatory and homeostatic chemokines has been introduced ...
Zoltán Szekanecz, Alisa E. Koch
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