Extended repertoire of CXC chemokines acting as agonists and antagonists of the human and murine atypical chemokine receptor ACKR2. [PDF]
Luís R +3 more
europepmc +1 more source
PARPi Combining Nanoparticle LIN28B siRNA for the Management of Malignant Ascites
This study demonstrates that co‐inhibition of LIN28B and PARP using siLin28b/DSSP@lip‐PEG‐FA nanoparticles in combination with the PARP inhibitor BMN673 effectively suppresses the accumulation of malignant ascites associated with advanced cancers.
Yan Fang +13 more
wiley +1 more source
Estradiol Promotes Myelin Repair in the Spinal Cord of Female Mice in a CXCR4 Chemokine Receptor-Independent Manner. [PDF]
Bardy-Lagarde M +3 more
europepmc +1 more source
p16Ink4a‐Positive Hepatocytes Drive Liver Fibrosis Through Activation of LIFR Family Pathway
This study found that, following the long‐term CCl4 treatment, p16high hepatocytes appeared in zone 3, spatially co‐localizing with fibrotic areas. A specific cluster of p16high hepatocytes upregulated CTF1/LIF expression which induced HSC activation and further liver fibrosis, as revealed by single cell transcriptomic analysis.
Koji Nishikawa +23 more
wiley +1 more source
The role of the 3'-UTR of the chemokine receptor CCR2 and hnRNPA0 in regulating mRNA stability and subcellular distribution in human CD4<sup>+</sup> T cells. [PDF]
Yukselten Y +3 more
europepmc +1 more source
A Mussel‐Inspired Bioadhesive Patch to Selectively Kill Glioblastoma Cells
An innovative mussel‐inspired bioadhesive patch has been developed for post‐surgical glioblastoma treatment. The patch, which adheres strongly in biological environments, releases a localized treatment. This treatment, acting via reactive oxygen species, shows specific toxicity to glioblastoma cells.
Jose Bolaños‐Cardet +5 more
wiley +1 more source
Prognostic impact and landscape of cellular CXCR5 chemokine receptor expression in clear-cell renal cell carcinoma. [PDF]
Arai M +8 more
europepmc +1 more source
This study shows that monocytes in multiple myeloma display an excessive interferon response, leading to transcriptional reprogramming and altered differentiation. Using single‐cell sequencing, coculture experiments, and patient samples before and after therapy, the authors demonstrate that induction treatment reduces this interferon response ...
Jian Cui +18 more
wiley +1 more source

