Results 241 to 250 of about 369,183 (362)

Chemokine and Chemokine-Receptor Expression in Human Glial Elements [PDF]

, 2000
Carrie M. McManus, Karen M. Weidenheim, Scott E. Woodman, Jeranil Nunez, Joseph Hesselgesser, Avindra Nath, Joan W. Berman   +6 more
openalex   +1 more source

Glucose Deprivation‐Induced Disulfidptosis via the SLC7A11‐INF2 Axis: Pan‐Cancer Prognostic Exploration and Therapeutic Validation

Advanced Science, EarlyView.
Glucose deprivation or GLUT1 inhibition induces disulfidptosis in SLC7A11high ovarian cancer cells by promoting cystine accumulation, NADPH/ATP depletion, and F‐actin disulfide formation. SLC7A11 interacts with INF2 to further increase H₂O₂ levels and impair mitochondrial fission, suppressing cell migration. Targeting the SLC7A11–INF2 axis represents a
Zhenyu Song, Qiuming Yao, Lina Huang, Dan Cui, Jun Xie, Leilei Wu, Jianfeng Huang, Bo Zhai, Dan Liu, Xiao Xu   +9 more
wiley   +1 more source

Bystander Expression of Atypical Chemokine Receptor 2 Protects T Cells from Chemoattraction towards Cancer-Associated Fibroblasts. [PDF]

Eur J Immunol
Tang R, Tay SS, Sharbeen G, Herrmann D, Youkhana J, Timpson P, Phillips PA, Biro M.   +7 more
europepmc   +1 more source

Cathepsin K Aggravates Pulmonary Fibrosis Through Promoting Fibroblast Glutamine Metabolism and Collagen Synthesis

Advanced Science, EarlyView.
CTSK plays a critical role in pulmonary fibrosis. Excessive CTSK accumulation interacts with SNX9 to enhance TGF‐β1‐induced SMAD3 activation and GLS1 expression in fibroblasts, driving glutamine metabolism for collagen biosynthesis and exacerbating pulmonary fibrosis.
Mengting Chen, Xiaoxiao Meng, Yong Zhu, Dapeng Wang, Mengmeng Wang, Ziyuan Wang, Xue Tian, Jiaxiang Zhang, Zhiying Yue, Zhengfeng Yang, Ruilan Wang   +10 more
wiley   +1 more source

The immunosuppressive role of neutrophils in infectious and oncological conditions: A study of chemokine receptor CXCR3 and human neutrophil lipocalin levels. [PDF]

BMC Res Notes
Irakli K, Ekaterina K, Mladen K.
europepmc   +1 more source

CC-chemokine receptor variants, SDF-1 polymorphism, and disease progression in 720 HIV-infected patient

, 1999
Laurence Meyer, Magda Magierowska, J-B. Hubert, Ioannis Theodorou, Ronald Van Rij, Maria Prins, A-M. de Roda Husman, R A Coutinho, Hanneke Schuitemaker   +8 more
openalex   +1 more source

Targeting Cystine Metabolism in the Lung Cancer Environment Enhances the Efficacy of Immune Checkpoint Inhibition

Advanced Science, EarlyView.
The tumor‐associated macrophages (TAMs) in lung cancer tissues exhibit active cystine metabolism. Restricting cystine concentration in macrophages induces M1 phenotypic polarization and upregulation of PD‐L1 expression through the GSH‐NF‐κB signaling pathway.
Yun Xu, Shumin Li, Jiaji Wu, Shumin Xu, Mo Shen, Chenyang Wang, Lundqvist Andreas, Jianghao Yu, Zhiyong Xu, Yueli Shi, Nana Liu, Yunke Yang, Jiangnan Zhao, Ying Yang, Pingli Wang, Peng Yi, Jin Cheng, Junhui Sun, Mengshu Li, Peng Xiao, Kai Wang   +20 more
wiley   +1 more source

Targeting the atypical chemokine receptor 2 (<i>Ackr2</i>) improves the benefit of anti-PD-1 immunotherapy in melanoma mouse model. [PDF]

Oncoimmunology
Noman MZ, Szpakowska M, Xiao M, Gao R, Van Moer K, Kumar A, Ollert M, Berchem G, Chevigné A, Janji B.   +9 more
europepmc   +1 more source

Chemokine receptors and HIV-2

, 1997
Alonso Heredia, Alejandro Vallejo, Vincent Soriano, Jay S. Epstein, Indira K. Hewlett   +4 more
openalex   +1 more source

The LDH‐H3K18La‐Nur77 Axis Potentiates Immune Escape in Small Cell Lung Cancer

Advanced Science, EarlyView.
Lactate from SCLC tumors induces H3K18 lactylation in naïve CD8+ T cells, upregulating Nurr77 and enhancing tonic TCR signaling. This leads to T cell hyporesponsiveness to stimulation, impairing antitumor immunity and reducing immunotherapy efficacy.
Xiaoling Shang, Bo Cheng, Chenyue Zhang, Chenglong Zhao, Ruiqing Wang, Xun Zhang, Dizhi Jiang, Xinyu Zhang, Xinyue Ma, Hongyuan Mao, Zerun Li, Chenhan Huang, Tianzi Wang, Kaiyue Guo, Liwen Wang, Ning Tang, Haiyong Wang   +16 more
wiley   +1 more source