Structural basis for chemokine recognition and receptor activation of chemokine receptor CCR5 [PDF]
Nature Communications, 2021 The chemokine receptor CCR5 plays multiple roles in the immune system. Here, structures of Gi1 protein-coupled CCR5 with or without a chemokine bound and of the CCR5- chemokine MIP-1 α complex offer insight into the distinct binding modes of the ligands ...
Hui Zhang +11 more
doaj +7 more sources
The expression of the chemokine receptor CCR5 in tick-borne encephalitis. [PDF]
J Neuroinflammation, 2016 Chemokine receptor 5 (CCR5) is hypothesized to drive the lymphocyte migration to central nervous system in flavivirus encephalitis, and the non-functional CCR5Δ32 genetic variant was identified as a risk factor of a West Nile virus infection and of tick ...
Grygorczuk S +9 more
europepmc +6 more sources
The chemokine receptor CCR5: multi-faceted hook for HIV-1. [PDF]
RetrovirologyChemokines are cytokines whose primary role is cellular activation and stimulation of leukocyte migration. They perform their various functions by interacting with G protein-coupled cell surface receptors (GPCRs) and are involved in the regulation of ...
Faivre N, Verollet C, Dumas F.
europepmc +5 more sources
An agent-based model of triple-negative breast cancer: the interplay between chemokine receptor CCR5 expression, cancer stem cells, and hypoxia. [PDF]
BMC Syst Biol, 2017 BackgroundTriple-negative breast cancer lacks estrogen, progesterone, and HER2 receptors and is thus not possible to treat with targeted therapies for these receptors.
Norton KA +3 more
europepmc +4 more sources
Interaction of Chemokine Receptor CCR5 with its Ligands: Multiple Domains for HIV-1 gp120 Binding and a Single Domain for Chemokine Binding [PDF]
Journal of Experimental Medicine, 1997 CCR5 is a chemokine receptor expressed by T cells and macrophages, which also functions as the principal coreceptor for macrophage (M)-tropic strains of HIV-1. To understand the molecular basis of the binding of chemokines and HIV-1 to CCR5, we developed
Lijun Wu +11 more
semanticscholar +2 more sources
In vitro pharmacoregulation of CC chemokine ligand 5 and its receptor CCR5 in diffuse lung diseases [PDF]
Mediators of Inflammation, 2003 Background: CC chemokine ligand (CCL)5 and its receptor CCR5 contribute to leukocyte migration into lungs of patients with diffuse lung diseases (DLD). Pharmacological regulation of CCL5 and CCR5 expression was therefore explored in bronchoalveolar cells
Veronika Sekerova +6 more
doaj +2 more sources
Investigation of Inhibition Mechanism of Chemokine Receptor CCR5 by Micro-second Molecular Dynamics Simulations. [PDF]
Sci Rep, 2015 Chemokine receptor 5 (CCR5) belongs to G protein coupled receptors (GPCRs) and plays an important role in treatment of human immunodeficiency virus (HIV) infection since HIV uses CCR5 protein as a co-receptor.
Salmas RE, Yurtsever M, Durdagi S.
europepmc +2 more sources
Blockade of the chemokine receptor, CCR5, reduces the growth of orthotopically injected colon cancer cells via limiting cancer-associated fibroblast accumulation. [PDF]
Oncotarget, 2016 We previously demonstrated that cancer-associated fibroblasts (CAFs) accumulate at tumor sites through the interaction between a chemokine, CCL3, and its receptor, CCR5, in the late phase of colitis-associated colon carcinogenesis.
Tanabe Y, Sasaki S, Mukaida N, Baba T.
europepmc +2 more sources
β-Chemokine Receptor CCR5 Signals through SHP1, SHP2, and Syk* [PDF]
Journal of Biological Chemistry, 2000 The β-chemokine receptor CCR5 has been shown to modulate cell migration, proliferation, and immune functions and to serve as a co-receptor for the human immunodeficiency virus.
R. Ganju +4 more
semanticscholar +2 more sources
Exploration of bivalent ligands targeting putative mu opioid receptor and chemokine receptor CCR5 dimerization. [PDF]
Bioorg Med Chem, 2016 Modern antiretroviral therapies have provided HIV-1 infected patients longer lifespans and better quality of life. However, several neurological complications are now being seen in these patients due to HIV-1 associated injury of neurons by infected ...
Arnatt CK +10 more
europepmc +3 more sources